Results 211 to 220 of about 320,721 (362)

Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis [PDF]

, 2015
Eisuke Nakadera, Shunhei Yamashina, Kousuke Izumi, Yoshihiro Inami, Toshifumi Sato, Hirofumi Fukushima, Kazuyoshi Kon, Kenichi Ikejima, Takashi Ueno, Sumio Watanabe   +9 more
openalex   +1 more source

Pharmacological Targeting of PI3K/Akt/mTOR and Wnt/GSK-3β Signaling in Oligodendrocyte Differentiation and Remyelination. [PDF]

Cells
Kim ME, Lee JS.
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Synergistic Cytotoxic Effect of a Novel mTOR/PI3K Dual Inhibitor PF-04691502 and Radiation Therapy on Neuroendocrine Tumor Cells [PDF]

, 2020
Z. Chow
openalex   +1 more source

Mendelian Randomization Revealed Potential of mTOR Inhibitors for Treatment of Osteoporosis: Evidence From GWAS and Transcriptome Data. [PDF]

Int J Endocrinol
Zhang Z, Zhou L, Yao L, Ma T, Xu Y.
europepmc   +1 more source

Identification of mTOR inhibitor-resistant genes in cutaneous squamous cell carcinoma

, 2018
Seong-Lan Yu,1 Dong Chul Lee,2 Seung Woo Baek,3 Do Yeun Cho,3 Jong Gwon Choi,3 JaeKu Kang1 1Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Republic of Korea; 2Biotherapeutics Translational Research Center, Korea ...
Yu SL, Cho DY, Choi JG, Kang J, Lee DC, Baek SW   +5 more
core  

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

MTOR wt Allele [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways. [PDF]

Aging Cell
Li J, Zhang Y, Yu D, Li J, Chen K, Chu L.   +5 more
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source