Results 221 to 230 of about 320,721 (362)

Celastrol suppresses mTOR signaling by altering its association with chaperones and inducing its ubiquitination in breast cancer cells

, 2018
Weiying Zhou, Xiaoli Li, Xintong Yao, Duanfang Zhou, Liangyuan Long   +4 more
openalex   +2 more sources

Erratum: Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor [PDF]

, 2016
A Carpentieri, E Cozzoli, M Scimeca, Elena Bonanno, Anna Maria Sardanelli, Alessandra Gambacurta   +5 more
openalex   +1 more source

Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markers. [PDF]

World Allergy Organ J
Zhou X, Wang Z, Zheng S.
europepmc   +1 more source

A Sprayable Nanoplatform Breaks the Vicious Cycle of Diabetic Wounds via Photoactivated Antioxidant and Drug Delivery

Advanced Science, EarlyView.
A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo, Yuanyuan Meng, Qixiang Gui, Xi‐Tao Yang, Yong Fan, Xiaodong Zhu   +5 more
wiley   +1 more source

Participação da proteína mTOR hipocampal na consolidação e reconsolidação da memória de reconhecimento de objetos em ratos

, 2008
Jociane de Carvalho Myskiw
openalex   +1 more source

PKA signaling modulates PRMT5/hnRNP A1-mediated IRES translation and dictates responses to mTOR inhibition in glioblastoma. [PDF]

J Neurooncol
Kumar S, Benavides-Serrato A, Saunders JT, Nishimura RN, Gera JF.   +4 more
europepmc   +1 more source

Viral exploitation of mTOR [PDF]

Nature Immunology, 2018
openaire   +2 more sources

NAMPT inhibition impairs mTOR-dependent regulation of translation in melanomaNAMPT inhibition impairs mTOR-dependent regulation of translation in melanoma.

The frequent emergence of drug resistance in melanoma remains a challenge. This phenomenon relies on the rewiring of multiple processes, including cancer metabolism, epigenetics, translation process, and interactions with the tumor microenvironment ...
Valentina Audrito., Alessia Ponzano, Luca Ponzone, Claudia Landi, Beatrice Ghezzi, Irene Fiorilla, Veronica De Giorgis, Vincenzo Calautti, Alberto Maria Todesco, Enrico Moiso, Marcello Manfredi   +10 more
core  

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Neuroprotective Role of Orientin on β-amyloidinduced Cell Death in SH-SY5Y Neuronal Cells via mTOR Signaling Pathway

, 2023
Ying Pei Wong, Rhun Yian Koh, Kenny Leong Voon, Anna Pick, K.B. Ling, Z Zhu, C Yang, A Iyaswamy, S Krishnamoorthi, S Sreenivasmurthy, J Liu, Z Wang, B Tong, J Song, J Lu, K Cheung, M Li, S Oddo, Y Kim, K Guan, B Law, A Ling, R Koh, S Chye, Y Wong, R Subramaniam, F Roediger, B Jordan, M Mattson, J Keller, G Waeg, D Butterfield, C Pocernich, A Cardin, C Racine, C Lauderback, D Butterfield, J Tanaka, Y Yuda, T Miura, S Muraoka, Y Fujimoto, T Collins, M Berridge, P Lipp, M Bootman, S Hauptmann, I Scherping, S Drse, U Brandt, K Schulz, M Jendrach, K Leuner, A Eckert, W Mller, K Lim, A Sasmita, A Ling, R Koh, K Voon, Y Say, Y Wong, L Yu, S Wang, X Chen, H Yang, X Li, Y Xu, X Zhu, A Dinkova-Kostova, A Abramov, A Gureev, V Popov, A Starkov, C Goodman, D Mayhew, T Hornberger, A Tramutola, J Triplett, F Di Domenico, D Niedowicz, M Murphy, R Coccia, M Perluigi, D Butterfield, J Frey, B Jacobs, C Goodman, T Hornberger, H Lee, B Kwon, C Lemere, S De La Monte, K Itamura, A Ha, H Querfurth, R Hresko, M Mueckler   +97 more
openalex   +1 more source