Results 241 to 250 of about 375,497 (354)

Evolutionary perspectives on endometrial cancer: antagonistic pleiotropy. [PDF]

Mol Cell Oncol
Kobayashi H.
europepmc   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy. [PDF]

Int J Mol Med
Miao Z, Liu B, Zhou X, Lu M, Jia N, Zhang H, Qi Y, Tan X, Zhang Q.   +8 more
europepmc   +1 more source

mTOR in cerebrovascular disease

Aging, 2019
Van Skike, Candice E., Galvan, Veronica
openaire   +2 more sources

UHPLC–MS based metabolomics study of the ErZhi formula on skeletal muscle against osteosarcopenia focusing on energy metabolism

Animal Models and Experimental Medicine, EarlyView.
ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang, Ningning Li, Yujie Ding, Shuzhen Hou, Jing Liu, Xiuxue Liu, Erwei Liu, Xiaopeng Chen   +7 more
wiley   +1 more source

RagC and Map4K3 deficiency in high-grade gliomas drives proliferation and modulates mTORC1-dependent cellular functions. [PDF]

J Neuropathol Exp Neurol
Kahr J, Diaz-Peregrino R, Sandalcioglu IE, John P, Mawrin C.   +4 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

mTORC2-Na_v1.2 signaling drives early hyperexcitability in Alzheimer's disease mouse model. [PDF]

Channels (Austin)
Dvorak NM, Noebels JL.
europepmc   +1 more source

Investigation of metformin analogues in targeting signaling molecules of head and neck cancer pathways by computational approaches. [PDF]

Sci Rep
Arora P, Kollur SP, Shanthappa PM, Yadav B, Tenguria M, Rai N, Upadhye VJ, Singh P.   +7 more
europepmc   +1 more source

Targeting mTOR: up-to-date mTOR inhibitors

Biorganic and Medicinal Chemistry Reports, 2019
Banu Kilic, Meryem Temiz-Resitoglu, Seyhan Sahan Firat   +2 more
openaire   +1 more source