Results 251 to 260 of about 320,721 (362)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Tricetin, a DietaryFlavonoid, Alleviates Neuroinflammationand Promotes Autophagy in Alzheimer’s Disease by Regulatingthe PI3K/Akt/mTOR Signaling Pathway

Xinyuan Wu (1593211), Dan Su (8007), Jiaxin Xu (11526724), Ge Ge (4325986), Yongzhen Zhang (1616953), Bingjian Wu (21085546), Kun Hu (119408), Jie Ren (176083), Hao Yang (328526)   +8 more
openalex   +1 more source

Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

, 2020
Qing Xu, Sheng‐Tian Li, Weidong Li, Longyong Xu, Adele Pin Chen, Ziqi Zhu, Eiki Takahashi, Yanfei Han, Guang He, Youming Deng, Ying Zhou, Juan Song, Lulu Song, Lin He, Lu Yu, Shuai Wang, Xuemei Chen, Charlie Degui Chen   +17 more
openalex   +1 more source

mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging [PDF]

, 2009
Rogério M. Castilho, Cristiane H. Squarize, Lewis A. Chodosh, Bart O. Williams, J. Silvio Gutkind   +4 more
openalex   +1 more source

mTOR Inhibition Drives Mutation-Specific Remodeling of Lysosomal and Autophagic Pathways and GCase Activity in PBMC-Derived Macrophages from Patients with GBA1-Associated Parkinson's Disease. [PDF]

Curr Issues Mol Biol
Bezrukova A, Basharova K, Emelyanov A, Lavrinova A, Krapova A, Galkina E, Skudarnova E, Baydakova G, Miliukhina I, Zakharova E, Pchelina S, Usenko T.   +11 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Fit cells, fertile ground: Immunometabolic programming and bone marrow niche support in durable CAR T cell response in leukemia. [PDF]

Mol Ther Oncol
Wang X, Goldberg L.
europepmc   +1 more source

mTOR in cerebrovascular disease

Aging, 2019
Van Skike, Candice E., Galvan, Veronica
openaire   +2 more sources

Phenformin-Induced Apoptosis: A Potential Mechanism for Cervical Cancer Cell Inhibition. [PDF]

Int J Mol Sci
Subaiea GM, Amangelsin Y, Sagatbekova K, Katamesh AA, Alkubati SA, Alobaida AA, Atia HA, Khalifa NE, Alshammari TM, Ishak R, Aljofan M.   +10 more
europepmc   +1 more source

Neuroprotective effects of <i>Platycladus orientalis</i> ethyl acetate fraction on retinal Müller cells: modulation of AKT1/mTOR and Raf-1/MEK1/2 pathways via AMPK activation. [PDF]

Front Mol Biosci
Lim JX, Yong PH, Lim SH, Ng ZX.
europepmc   +1 more source