Results 261 to 270 of about 375,497 (354)

UBE2C promotes pancreatic cancer progression through PI3K/Akt/mTOR signaling pathway. [PDF]

Cell Cycle
Zhou Z, Chen Y, Li P.
europepmc   +1 more source

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.

Cancer Research, 2006
K. O'reilly, F. Rojo, Q. She, D. Solit, G. Mills, Debra L. Smith, H. Lane, F. Hofmann, D. Hicklin, D. Ludwig, J. Baselga, N. Rosen   +11 more
semanticscholar   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Leonurine-Standardized <i>Leonurus japonicus</i> Extract Promotes Recovery from Immobilization-Induced Muscle Atrophy via PI3K/Akt/mTOR Signaling in Mice. [PDF]

J Microbiol Biotechnol
Lee J, Kim MB, Kim C, Moon CY, Kang H, Hwang JK.   +5 more
europepmc   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

mTOR Inhibition Drives Mutation-Specific Remodeling of Lysosomal and Autophagic Pathways and GCase Activity in PBMC-Derived Macrophages from Patients with GBA1-Associated Parkinson's Disease. [PDF]

Curr Issues Mol Biol
Bezrukova A, Basharova K, Emelyanov A, Lavrinova A, Krapova A, Galkina E, Skudarnova E, Baydakova G, Miliukhina I, Zakharova E, Pchelina S, Usenko T.   +11 more
europepmc   +1 more source

Distinct molecular pathways supporting Sjögren's Disease clusters and disease progression.

Arthritis &Rheumatology, Accepted Article.
Objective Sjögren's disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined SjD patient clusters: (1) B‐cell active with low symptoms (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptoms (LSAHS).
Sacha E Silva‐Saffar, Yann Nguyen, Raphaèle Seror, Jacques‐Eric Gottenberg, Anna Niarakis, Xavier Mariette, Gaetane Nocturne   +6 more
wiley   +1 more source

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Nature Genetics, 2004
B. Ravikumar, C. Vacher, Z. Berger, J. Davies, S. Luo, L. Oroz, F. Scaravilli, D. Easton, R. Duden, C. O’Kane, D. Rubinsztein   +10 more
semanticscholar   +1 more source

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice

Autism Research, EarlyView.
ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown.
Krisztina Sáfár, Vivien Szendi, Paulina Hoppa, Yutong Wang, Fanni Á. Seres, Szilvia Bartók, Tyler Teadora, Lei Shi, Árpád Dobolyi, Gina Puska, István Adorján   +10 more
wiley   +1 more source

Phenformin-Induced Apoptosis: A Potential Mechanism for Cervical Cancer Cell Inhibition. [PDF]

Int J Mol Sci
Subaiea GM, Amangelsin Y, Sagatbekova K, Katamesh AA, Alkubati SA, Alobaida AA, Atia HA, Khalifa NE, Alshammari TM, Ishak R, Aljofan M.   +10 more
europepmc   +1 more source