Results 221 to 230 of about 427,120 (360)

<p>Salvianolic acid A attenuates CCl₄-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways</p>

, 2019
Rong Wang, Fuxing Song, Shengnan Li, Bin Wu, Yanqiu Gu, Yongfang Yuan   +5 more
openalex   +2 more sources

Supplimentary_Figure1-14 and Table 1-2 from Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma

, 2023
Xinhua Song, Xianqiong Liu, Haichuan Wang, Jingxiao Wang, Qiao Yu, Antonio Cigliano, Kirsten Utpatel, Silvia Ribback, Maria G. Pilo, Marina Serra, John D. Gordan, Li Che, Shanshan Zhang, Antonio Cossu, Alberto Porcu, Rosa M. Pascale, Frank Dombrowski, Hongbo Hu, Diego F. Calvisi, Matthias Evert, Xin Chen   +20 more
openalex   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling. [PDF]

Int J Mol Sci
Cipriano GL, Floramo A, Argento V, Oddo S, Artimagnella O.   +4 more
europepmc   +1 more source

Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling

, 2019
Rajinikanth Gogiraju, Astrid Hubert, Jörg Fahrer, Beate K. Straub, Moritz Brandt, Philip Wenzel, Thomas Münzel, Stavros Konstantinides, Gerd Hasenfuß, Katrin Schäfer   +9 more
openalex   +2 more sources

Data from Synergistic Action of a RAF Inhibitor and a Dual PI3K/mTOR Inhibitor in Thyroid Cancer

, 2023
Ning Jin, Tianyun Jiang, David Rosen, Barry D. Nelkin, Douglas W. Ball   +4 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

mTOR in radiotherapy of lung cancer: Mechanisms of radiation resistance and therapeutic implications (Review). [PDF]

Int J Oncol
Pang X, Liu H, Long Y, Wang H.
europepmc   +1 more source

<p>Dual PI3K/mTOR Inhibitor, XL765, suppresses glioblastoma growth by inducing ER stress-dependent apoptosis</p>

, 2019
Hang Zhao, Guangyong Chen, Huaxin Liang
openalex   +2 more sources

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source