Results 221 to 230 of about 266,976 (313)

[Research advances in the role of mTOR signaling pathway in autism spectrum disorder].

, 2019
Guoxia Sheng, Kewen Jiang
openalex   +2 more sources

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Molecular interplay of ASNS and the PI3K-AKT-mTOR pathway in CMV and HIV co-infections: Therapeutic implications. [PDF]

PLoS One
Zhang H, Yuan S, Ding S, Bao H, Chen W, Cai B, Sun J, Zhu H, Lu W, Fang Y.   +9 more
europepmc   +1 more source

ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway [PDF]

Ying Wang, Jiang Chang, Fa Wang, Lianying Lai, ShiXu Yang, Yueying Fu, Xingtian Ma, Chuan Yun   +7 more
openalex   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer's Therapeutic Approach by Suppressing Alzheimer's Disease-Related Protein Deposition. [PDF]

CNS Neurosci Ther
Chen Y, Ji X, Zhao J, Bao Z, Huang Y.
europepmc   +1 more source

肺リンパ脈管筋腫症におけるIntracrine機構による性ステロイドホルモン産生とmammalian target of rapamycin(mTOR)シグナル経路の発現

, 2015
厚子 安達
openalex   +1 more source

PI3K/Akt/mTOR-mediated bidirectional regulation of ampelopsin from Nekemias megalophylla modulates autophagy and apoptosis in cervical cancer [PDF]

Shiyi Xu, Siyu Liao, Juan Xi, Ling Gong, Xue Zou, Xiaoli Yang, Jiangli Di, Xiuqiao Zhang, Chun Gui   +8 more
openalex   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source