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mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy
Hematology/Oncology Clinics of North America, 2012Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase. It is ubiquitously expressed in cells and is a therapeutic target for the cancer treatment arsenal. Despite the great responses obtained in tumors addicted to specific mutations or overactivation of key members of the mTOR pathway (HiF1α in RCC, cyclin D1 in MCL, or TSC in SEGA),
Alejandro, Gomez-Pinillos +1 more
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Science, 2007
A mitochondrial membrane protein links two parts of a signaling pathway that is central to cell growth and proliferation.
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A mitochondrial membrane protein links two parts of a signaling pathway that is central to cell growth and proliferation.
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Diabetes Research and Clinical Practice, 2015
The mammalian target of rapamycin (mTOR) inhibitors are drugs, primarily used as immunosuppressors that are now frequently used as antineoplastic therapies in various cancers (such as advanced renal cell carcinoma, advanced breast cancer, progressive pancreatic neuroendocrine tumors).
Bruno, Vergès, Bertrand, Cariou
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The mammalian target of rapamycin (mTOR) inhibitors are drugs, primarily used as immunosuppressors that are now frequently used as antineoplastic therapies in various cancers (such as advanced renal cell carcinoma, advanced breast cancer, progressive pancreatic neuroendocrine tumors).
Bruno, Vergès, Bertrand, Cariou
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mTOR at the nexus of nutrition, growth, ageing and disease
Nature Reviews Molecular Cell Biology, 2020Grace Y Liu, David M Sabatini
exaly
Nihon rinsho. Japanese journal of clinical medicine, 2010
Mammalian target of rapamycin (mTOR) protein complex functions as an integration center for various intracellular signaling pathways involving proliferation, cell survival, and angiogenesis. These pathways are frequently abnormally regulated in cancer.
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Mammalian target of rapamycin (mTOR) protein complex functions as an integration center for various intracellular signaling pathways involving proliferation, cell survival, and angiogenesis. These pathways are frequently abnormally regulated in cancer.
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Gan to kagaku ryoho. Cancer & chemotherapy, 2011
Mammalian target of rapamycin(mTOR)exists downstream in the PI3K/AKT signal transmission pathway that is constantly activated in many cancers. It regulates translation of mRNA that codes for proteins involved in survival signals, such as for the cell cycle and apoptosis, by phosphorylation of p70S6K and 4E-BP1 that are further downstream.
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Mammalian target of rapamycin(mTOR)exists downstream in the PI3K/AKT signal transmission pathway that is constantly activated in many cancers. It regulates translation of mRNA that codes for proteins involved in survival signals, such as for the cell cycle and apoptosis, by phosphorylation of p70S6K and 4E-BP1 that are further downstream.
openaire +1 more source