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mTOR substrate phosphorylation in growth control.
Cell, 2022The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved serine/threonine protein kinase that plays a central role in regulating cell growth and metabolism. It is activated by nutrients, growth factors, and cellular energy. TOR forms
Stefania Battaglioni +4 more
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Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer.
Seminars in Cancer Biology, 2021Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is one of the most frequently dysregulated signaling pathways observed in cancer patients that plays crucial roles in promoting tumor initiation, progression and therapy ...
Le Yu, Jessica Wei, Pengda Liu
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mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
International Journal of Molecular Sciences, 2019 The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in regulation of cell survival, metabolism, growth and protein synthesis in response to upstream signals in both normal physiological and pathological conditions ...
Tian Tian, Xiaoyi Li, Jinhua Zhang
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mTOR Pathway and mTOR Inhibitors as Agents for Cancer Therapy
Current Cancer Drug Targets, 2008Research into mTOR, mammalian Target Of Rapamycin as an important drug target continues to be extremely interesting, both in terms of the increased molecular knowledge being acquired at the basis of various human diseases, and also for possible applications in drug cancer therapy.
Paolo, Baldo +5 more
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mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy
Hematology/Oncology Clinics of North America, 2012Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase. It is ubiquitously expressed in cells and is a therapeutic target for the cancer treatment arsenal. Despite the great responses obtained in tumors addicted to specific mutations or overactivation of key members of the mTOR pathway (HiF1α in RCC, cyclin D1 in MCL, or TSC in SEGA),
Alejandro, Gomez-Pinillos +1 more
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The immunobiology of mTOR in autoimmunity
Journal of Autoimmunity, 2020The mechanistic target of rapamycin (mTOR) is a master regulator of the inflammatory response in immune and non-immune cells. In immune cells mTOR regulates metabolism to fuel cell fate decision, proliferation and effector functions. In non-immune cells, such as fibroblast, it controls inflammation-associated proliferation and migration/invasion ...
Takahito, Suto, Thomas, Karonitsch
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Seminars in Cancer Biology, 2019
Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in the regulation of cell survival, growth, and proliferation ...
Meran Keshawa Ediriweera +2 more
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Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in the regulation of cell survival, growth, and proliferation ...
Meran Keshawa Ediriweera +2 more
exaly +2 more sources
mTOR signalling and cellular metabolism are mutual determinants in cancer
Nature Reviews Cancer, 2018Michael N Hall, Hall Michael N
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Gene, 2016
Mammalian target of rapamycin (mTOR), which is a member of the serine/threonine protein kinase family, is a protein complex that has a central role of cell growth and proliferation. mTOR emerges as a critical cell growth checkpoint on phosphoinositide 3-kinase (PI3K) signaling pathway.
Zekeriya Duzgun +2 more
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Mammalian target of rapamycin (mTOR), which is a member of the serine/threonine protein kinase family, is a protein complex that has a central role of cell growth and proliferation. mTOR emerges as a critical cell growth checkpoint on phosphoinositide 3-kinase (PI3K) signaling pathway.
Zekeriya Duzgun +2 more
openaire +2 more sources
Diabetes Research and Clinical Practice, 2015
The mammalian target of rapamycin (mTOR) inhibitors are drugs, primarily used as immunosuppressors that are now frequently used as antineoplastic therapies in various cancers (such as advanced renal cell carcinoma, advanced breast cancer, progressive pancreatic neuroendocrine tumors).
Bruno, Vergès, Bertrand, Cariou
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The mammalian target of rapamycin (mTOR) inhibitors are drugs, primarily used as immunosuppressors that are now frequently used as antineoplastic therapies in various cancers (such as advanced renal cell carcinoma, advanced breast cancer, progressive pancreatic neuroendocrine tumors).
Bruno, Vergès, Bertrand, Cariou
openaire +2 more sources