Results 321 to 330 of about 375,497 (354)

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside.

Seminars in Cancer Biology, 2019
Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway is one of the major cellular signaling pathways play an important role in basic intracellular functions.
A. Alzahrani
semanticscholar   +1 more source

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.

Biomaterials, 2019
Osteoarthritis (OA) is the most common disabling joint disease throughout the world and its therapeutic effect is still not satisfactory in clinic nowadays.
Jiangyi Wu, L. Kuang, Cheng Chen, Junjun Yang, W. Zeng, Tao Li, Hao Chen, Shu Huang, Zhenlan Fu, Jiamiao Li, Renfeng Liu, Z. Ni, Lin Chen, Liu Yang   +13 more
semanticscholar   +1 more source

Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy.

Seminars in Cancer Biology, 2019
The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of rapamycin (mTOR) represent two vital intracellular signaling pathways, which are associated with various aspects of cellular functions.
Devesh Tewari, P. Patni, Anusha Bishayee, A. Sah, A. Bishayee   +4 more
semanticscholar   +1 more source

mTOR

2016
Mar Castellanos, Carme Gubern, Elisabet Kadar   +2 more
  +5 more sources

mTOR — beyond transplantation

Current Opinion in Pharmacology, 2005
mTOR kinase plays a central role in the activation of many cell types, and blocking mTOR function with rapamycin results in arrest of the cell cycle at the G1 phase. Recently, several additional molecules have been identified in the mTOR pathway, providing further opportunities to interfere with cell activation and develop novel therapeutic agents ...
Deborah A, Young, Cheryl L, Nickerson-Nutter   +1 more
openaire   +2 more sources

mTOR Pathway and mTOR Inhibitors in Cancer Therapy

2010
1. N. Kubica and J. Blenis "mTORC1: A signaling integration node involved in cell growth" 2. Z. Feng and A.J. Levine "The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions" 3. H. Mead, M. Zeremski and M. Guba "mTOR Signaling in Angiogenesis" 4. J. Brugaroles "mTOR signaling and hypoxia" 5. D. Akhavan and P.S. Mischel "mTOR
openaire   +1 more source

mTOR

AfCS-Nature Molecule Pages, 2008
Robitaille, A. M., Hall, M. N.
openaire   +3 more sources

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Science, 2005
Dos D. Sarbassov, D. Guertin, Siraj M. Ali, D. Sabatini   +3 more
semanticscholar   +1 more source

Senescence Regulation by mTOR

2012
The senescence program is activated in response to diverse stress stimuli potentially compromising genetic stability and leads to an irreversible cell cycle arrest. The mTOR pathway plays a crucial role in the regulation of cell metabolism and cellular growth.
openaire   +2 more sources

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Nature Cell Biology, 2002
K. Inoki, Yong Li, Tian Zhu, Jun Wu, K. Guan   +4 more
semanticscholar   +1 more source