Results 171 to 180 of about 75,068 (344)

The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis [PDF]

, 2010
Jennifer M. Spangle, Karl Münger
openalex   +1 more source

Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases

BioEssays, EarlyView.
The Role of Ribosome Recycling in Human Diseases This diagram highlights how disruptions in ribosome translation and recycling can negatively impact cellular and organismal health. Usually, these processes operate efficiently to maintain cellular protein homeostasis.
Foozhan Tahmasebinia, Zhihao Wu
wiley   +1 more source

FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis [PDF]

, 2010
Boyi Gan, Carol S. Lim, Gerald Chu, Sujun Hua, Zhihu Ding, Michael P. Collins, Jian Hu, Shan Jiang, Eliot Fletcher-Sananikone, Li Zhuang, Michelle Chang, Hongwu Zheng, Yanru Wang, David J. Kwiatkowski, William G. Kaelin, Sabina Signoretti, Ronald A. DePinho   +16 more
openalex   +1 more source

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Cell, 2010
Y. Sancak, L. Bar-Peled, R. Zoncu, Andrew L. Markhard, S. Nada, D. Sabatini   +5 more
semanticscholar   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Increased mTORC1 Signaling UPRegulates Stress

, 2008
Jan H. Reiling, David M. Sabatini
openalex   +1 more source

STRADα deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice [PDF]

, 2010
Ksenia Orlova, Whitney E. Parker, Gregory G. Heuer, Victoria Tsai, Jason Yoon, Marianna Baybis, Robert S. Fenning, Kevin A. Strauss, Peter B. Crino   +8 more
openalex   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

ATM engages the TSC2/mTORC1 signaling node to regulate autophagy [PDF]

, 2010
Angela Alexander, Jinhee Kim, Cheryl L. Walker   +2 more
openalex   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source