Results 301 to 310 of about 75,068 (344)

TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells

The FEBS Journal, EarlyView.
TSC22D1 acts downstream of glucose signaling and negatively regulates insulin secretion in pancreatic beta cells. Mechanistically, TSC22D1 interacts with FoxO1. Elevated glucose levels enhance the TSC22D1–FoxO1 interaction indirectly by increasing the protein abundance of TSC22D1. Importantly, TSC22D1 and FoxO1 not only physically associate but also co‐
Sümbül Yıldırım, Amit Mhamane, Svenja Lösch, Annika Wieder, Ezgi Ermis, Ann‐Christine König, Sevgican Yilmaz, Stefanie M. Hauck, Fatih Kocabas, Julia Szendroedi, Stephan Herzig, Bilgen Ekim   +11 more
wiley   +1 more source

Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Role in Cystogenesis and Novel Therapeutic Approaches. [PDF]

Biomedicines
Gao J, Yu X.
europepmc   +1 more source

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB‐inhibitor‐induced phenotypes

The FEBS Journal, EarlyView.
Whole‐organism phosphoproteomics after ErbB inhibitor treatment was assessed in zebrafish embryos. Differential signaling was uncovered after treatments with more selective ErbB inhibitors and pan‐ErbB inhibitors, despite similar neurological and myocardial phenotypes.
Katri Vaparanta, Zejia Song, Iman Farahani, Anne Jokilammi, Johannes Merilahti, Johanna Örling, Noora Virtanen, Pekka Haapaniemi, Cecilia Sahlgren, Klaus Elenius, Ilkka Paatero   +10 more
wiley   +1 more source

Molecular Mechanisms of Cellular Senescence in Age-Related Endometrial Dysfunction. [PDF]

Cells
Kobayashi H, Umetani M, Nishio M, Shigetomi H, Imanaka S, Hashimoto H.   +5 more
europepmc   +1 more source

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

Immunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source

Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies. [PDF]

Cancer Biol Med
Lin Z, Chang C, Zhao S, Fang L, Wang P.
europepmc   +1 more source

Insulin resistance and exercise‐induced insulin sensitization in skeletal muscle: Insights from personalized phosphoproteomics

Journal of Diabetes Investigation, EarlyView.
Insulin resistance in muscle mainly disrupts non‐canonical insulin signaling pathways. Exercise‐induced MINDY1 S441 phosphorylation improves insulin sensitivity, highlighting its potential role in mediating exercise benefits in metabolic disease.
Shun Masuda, Takashi Matsuzaka
wiley   +1 more source

Heterogeneous Activation of Signaling Pathways and Therapeutic Vulnerabilities in KSHV-Associated Primary Effusion Lymphoma Cell Lines. [PDF]

J Med Virol
Huang L, Chen L, Huang Y, Gao SJ.
europepmc   +1 more source

White Paper on Nutrition Sensing and Ageing

Nutrition Bulletin, EarlyView.
ABSTRACT Ageing, which is defined as the progressive deterioration of physiological functions, is an inevitable part of the lifecycle. Nevertheless, its progress is believed to be influenced by modifiable factors, one of the most important being dietary intake.
Aygul Dagbasi, Adrian Holliday, Bernadette Carroll, Chiara de Lucia, Oliver M. Shannon, John Mathers, John McLaughlin, Chloe French, Aylin Hanyaloglu, Sorrel Burden, Douglas Morrison, Viktor Korolchuk, Gary Frost   +12 more
wiley   +1 more source

Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

J Obes Metab Syndr
Zahoor I, Mir GJ, Lone NA, Ashraf NU.
europepmc   +1 more source