Results 71 to 80 of about 75,068 (344)

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

Nature Communications, 2020
Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear.
Dan He, Hongguang Wu, Jinnan Xiang, Xinsen Ruan, Peike Peng, Yuanyuan Ruan, Ye-Guang Chen, Yibin Wang, Qiang Yu, Hongbing Zhang, S. Habib, R. A. De Pinho, Huijuan Liu, Baojie Li   +13 more
semanticscholar   +1 more source

Leucyl-tRNA synthetase regulates casein synthesis in dairy cows via the mTORC1-LAT1 pathway [PDF]

Animal Bioscience
Objective Leucyl-tRNA synthetase (LARS) is an essential multifunctional enzyme in mammals, pivotal in maintaining cellular protein and amino acid balance.
Yongding Ke, Ximeng Du, Binglan Chen, Xi Chen, Chengchuang Song, Xingtang Fang, Yanhong Wang, Chunlei Zhang   +7 more
doaj   +1 more source

Glutamine and asparagine activate mTORC1 independently of Rag GTPases

Journal of Biological Chemistry, 2020
Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy.
Delong Meng, Qianmei Yang, Huanyu Wang, Chase H. Melick, Rishika Navlani, A. Frank, Jenna L. Jewell   +6 more
semanticscholar   +1 more source

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. [PDF]

PLoS ONE, 2009
BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge   +7 more
doaj   +1 more source

Research advances of cell autophagy in focal segmental glomerulosclerosis

Linchuang shenzangbing zazhi
As a clinical pathological syndrome, focal segmental glomerulosclerosis （FSGS） is characterized by focal glomerulosclerosis, disappearance of podocyte processes and massive proteinuria. Current researches have confirmed that foot cell injury is a central
Min Zhang, Yan Mi, Cai-li Wang
doaj   +1 more source

Dihydroxyacetone phosphate signals glucose availability to mTORC1

Nature Metabolism, 2020
The mechanistic target of rapamycin complex 1 (mTORC1) kinase regulates cell growth by setting the balance between anabolic and catabolic processes. To be active, mTORC1 requires the environmental presence of amino acids and glucose.
Jose M. Orozco, Patrycja A. Krawczyk, Sonia M. Scaria, Andrew L Cangelosi, Sze Ham Chan, Tenzin Kunchok, C. Lewis, D. Sabatini   +7 more
semanticscholar   +1 more source

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

Nucleic Acids Research, 2021
LARP1 is a key repressor of TOP mRNA translation. It binds the m7Gppp cap moiety and the adjacent 5′TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex on these transcripts.
Jian-Jun Jia, R. Lahr, Michael T Solgaard, B. J. Moraes, R. Pointet, An-Dao Yang, Giovanna Celucci, T. Graber, Huy-Dung Hoang, Marius R Niklaus, I. Pena, A. K. Hollensen, Ewan M Smith, M. Chaker-Margot, L. Anton, Christopher Dajadian, M. Livingstone, Jaclyn Hearnden, Xu-dong Wang, Yonghao Yu, T. Maier, C. Damgaard, A. Berman, T. Alain, B. Fonseca   +24 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

The yin yang of sunitinib: One drug, two doses, and multiple outcomes

Molecular & Cellular Oncology, 2017
Our recent work showed that sunitinib exerts dual effect on cancer cells in different dose ranges. In clinically relevant doses, cancer cells tolerate sunitinb cytotoxicity by upregulating pro-survival MCL-1 and activating mTORC1 signaling. Inhibition of
Mohamed Elgendy
doaj   +1 more source

The crosstalk between MYC and mTORC1 during osteoclastogenesis

Frontiers in Cell and Developmental Biology, 2022
Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae, Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min   +10 more
doaj   +1 more source