Results 51 to 60 of about 66,391 (264)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. [PDF]
PLoS Pathogens, 2017 Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility.
Sharon K Kuss-Duerkop +13 more
doaj +1 more source
Micro(RNA) Managing by mTORC1 [PDF]
Molecular Cell, 2015 In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.
Jewell, Jenna L +2 more
openaire +4 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The yin yang of sunitinib: One drug, two doses, and multiple outcomes
Molecular & Cellular Oncology, 2017 Our recent work showed that sunitinib exerts dual effect on cancer cells in different dose ranges. In clinically relevant doses, cancer cells tolerate sunitinb cytotoxicity by upregulating pro-survival MCL-1 and activating mTORC1 signaling. Inhibition of
Mohamed Elgendy
doaj +1 more source
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. [PDF]
PLoS ONE, 2009 BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Aruna D Balgi +7 more
doaj +1 more source
Mac-2 Binding Protein Glycosylation Isomer (M2BPGi)-Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma. [PDF]
Ann Gastroenterol SurgM2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Shirabe K +8 more
europepmc +2 more sources
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
mTORC1 Regulates Glutamine Metabolism [PDF]
Cancer Discovery, 2013 Abstract mTORC1 stimulates glutamine metabolism by inducing glutamate dehydrogenase (GDH).
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Regulation of mTORC1 by amino acids [PDF]
Trends in Cell Biology, 2014 The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the ...
Bar-Peled, Liron, Sabatini, David
openaire +4 more sources