Results 41 to 50 of about 63,007 (266)
The crosstalk between MYC and mTORC1 during osteoclastogenesis
Frontiers in Cell and Developmental Biology, 2022 Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae +10 more
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Regulation of mTORC1 by amino acids [PDF]
Trends in Cell Biology, 2014 The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the ...
Bar-Peled, Liron, Sabatini, David
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Skeletal muscle signaling response to concurrent endurance and resistance exercise
Journal of Physical Fitness and Sports Medicine, 2015 Concurrent training, which is a combination of resistance exercise (RE) and endurance exercise (EE) performed in succession, is used to improve both muscle strength and cardiovascular function.
Yuhei Makanae +2 more
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The role of mTOR in age-related diseases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The ageing population is becoming a significant socio-economic issue. To address the expanding health gap, it is important to deepen our understanding of the mechanisms underlying ageing in various organisms at the single-cell level. The discovery of the
Zofia Chrienova +2 more
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Hematology/Oncology and Stem Cell Therapy, 2018 In recent years, tissue regeneration has become a promising field for developing stem cellbased transplantation therapies for human patients. Adult stem cells are affected by the same aging mechanisms that involve somatic cells.
Mohammadhossein Khorraminejad-Shirazi +5 more
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AKAP13 couples GPCR signaling to mTORC1 inhibition.
PLoS Genetics, 2021 The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focused on
Shihai Zhang +10 more
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
eLife, 2021 The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function.
Maren Heimhalt +15 more
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mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells
Disease Models & Mechanisms, 2019 Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive.
Robert A. Brown +8 more
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Multistep regulation of TFEB by MTORC1 [PDF]
Autophagy, 2017 The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization. However, TFEBS211A localizes diffusely in both cytoplasm and nucleus and, as we show, retains regulation by MTORC1.
Vega-Rubín-de-Celis, Silvia +3 more
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Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. [PDF]
PLoS Pathogens, 2017 Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility.
Sharon K Kuss-Duerkop +13 more
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