Results 41 to 50 of about 66,391 (264)

The role of mTOR in age-related diseases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The ageing population is becoming a significant socio-economic issue. To address the expanding health gap, it is important to deepen our understanding of the mechanisms underlying ageing in various organisms at the single-cell level. The discovery of the
Zofia Chrienova, Eugenie Nepovimova, Kamil Kuca   +2 more
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The crosstalk between MYC and mTORC1 during osteoclastogenesis

Frontiers in Cell and Developmental Biology, 2022
Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae, Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min   +10 more
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mTORC1 maintains metabolic balance [PDF]

Cell Research, 2015
Anticancer therapeutics aimed at the inhibition of mTORC1 activity shift metabolism to favor the degradation of extracellular proteins. Recently Thompson and colleagues demonstrated a novel regulatory mechanism whereby mTORC1 plays a distinct role as a key regulator of metabolism depending on the environmental nutrient status.
Heesun, Cheong, Daniel J, Klionsky
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Research advances of cell autophagy in focal segmental glomerulosclerosis

Linchuang shenzangbing zazhi
As a clinical pathological syndrome, focal segmental glomerulosclerosis （FSGS） is characterized by focal glomerulosclerosis, disappearance of podocyte processes and massive proteinuria. Current researches have confirmed that foot cell injury is a central
Min Zhang, Yan Mi, Cai-li Wang
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Aging and stem cell therapy: AMPK as an applicable pharmacological target for rejuvenation of aged stem cells and achieving higher efficacy in stem cell therapy

Hematology/Oncology and Stem Cell Therapy, 2018
In recent years, tissue regeneration has become a promising field for developing stem cellbased transplantation therapies for human patients. Adult stem cells are affected by the same aging mechanisms that involve somatic cells.
Mohammadhossein Khorraminejad-Shirazi, Mohammad Farahmandnia, Bahareh Kardeh, Alireza Estedlal, Sina Kardeh, Ahmad Monabati   +5 more
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AKAP13 couples GPCR signaling to mTORC1 inhibition.

PLoS Genetics, 2021
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focused on
Shihai Zhang, Huanyu Wang, Chase H Melick, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Tshering D Lama-Sherpa, Delong Meng, Kelly A Servage, Nicholas G James, Jenna L Jewell   +10 more
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An expanded role for mTORC1 in autophagy [PDF]

Molecular & Cellular Oncology, 2015
Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1.
Kim, Young-Mi, Park, Ji-Man, Grunwald, Douglas, Kim, Do-Hyung   +3 more
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mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells

Disease Models & Mechanisms, 2019
Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive.
Robert A. Brown, Antanina Voit, Manasa P. Srikanth, Julia A. Thayer, Tami J. Kingsbury, Marlene A. Jacobson, Marta M. Lipinski, Ricardo A. Feldman, Ola Awad   +8 more
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

eLife, 2021
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function.
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams   +15 more
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Regulation of mTORC1 by Upstream Stimuli [PDF]

Genes, 2020
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A significant amount of research has uncovered the signaling pathways regulated by mTORC1, and the involvement of ...
Chase H. Melick, Jenna L. Jewell
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