Results 31 to 40 of about 66,391 (264)
RETREG3/FAM134C phosphorylation by CSNK2 regulates reticulophagy during starvation
Autophagy Reports, 2022 Starvation is the most potent physiological inducer of autophagy, the catabolic process which degrades unessential cytosolic components to sustain cellular homeostasis and survival.
Giorgia Di Lorenzo +4 more
doaj +1 more source
The effect of resistance training on the AMPK-mTORC1-P70S6K1 signaling pathway in adipose tissue of obese mice with type 2 diabetes [PDF]
ورزش و علوم زیست حرکتیIntroduction and Purpose: The use of exercise training to correct metabolic disorders and treat diseases has become widespread. This study aimed to investigate the effect of eight weeks of resistance training on the expression of AMPK, mTORC1, and ...
Reyhaneh Gholami +4 more
doaj +1 more source
Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
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Leucyl-tRNA synthetase regulates casein synthesis in dairy cows via the mTORC1-LAT1 pathway [PDF]
Animal BioscienceObjective Leucyl-tRNA synthetase (LARS) is an essential multifunctional enzyme in mammals, pivotal in maintaining cellular protein and amino acid balance.
Yongding Ke +7 more
doaj +1 more source
Clinical and Experimental Hypertension, 2023 Objective: Excessive proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is a core event of pulmonary hypertension (PH). Regulators of G protein signaling 10 (RGS10) can regulate cellular proliferation and cardiopulmonary ...
Sheng Hu +3 more
doaj +1 more source
Regulation of mTORC1 by PI3K signaling [PDF]
Trends in Cell Biology, 2015 The class I phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation of mTORC1 [composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8(mLST8), 40-kDa proline-rich Akt substrate (PRAS40), and DEP domain ...
Christian C, Dibble, Lewis C, Cantley
openaire +2 more sources
Regulation of mTORC1 by the Rag GTPases
Biochemical Society Transactions, 2023 The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation is observed in multiple diseases such as cancer, obesity, metabolic disorders, and neurodegeneration ...
Tshering D. Lama-Sherpa +2 more
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Crosstalk of Hedgehog and mTORC1 Pathways [PDF]
Cells, 2020 Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and cellular metabolism, are both coordinated by the primary cilium. Observations from cancer cells strongly indicate crosstalk between Hh and mTOR signaling. This hypothesis is supported by several studies: Evidence points to a TGFβ-mediated crosstalk; Increased PI3K/AKT ...
Lasse Jonsgaard Larsen +1 more
openaire +3 more sources
Journal of the International Society of Sports Nutrition, 2019 Background Ursolic acid altered muscle protein metabolism in normal and resting conditions after acute resistance exercise, suggesting that eating fruits rich in ursolic acid could enhance muscle protein synthesis and decrease muscle degradation.
Yuhei Makanae +3 more
doaj +1 more source
Skeletal muscle signaling response to concurrent endurance and resistance exercise
Journal of Physical Fitness and Sports Medicine, 2015 Concurrent training, which is a combination of resistance exercise (RE) and endurance exercise (EE) performed in succession, is used to improve both muscle strength and cardiovascular function.
Yuhei Makanae +2 more
doaj +1 more source