Results 11 to 20 of about 103,930 (303)
Spatiotemporal feedforward between PKM2 tetramers and mTORC1 prompts mTORC1 activation
Physical Biology, 2022 Abstract Most mammalian cells couple glucose availability to anabolic processes via the mTORC1 pathway. However, the mechanism by which fluctuations in glucose availability are rapidly translated into mTORC1 signals remains elusive. Here, we show that cells rapidly respond to changes in glucose availability through the spatial coupling ...
Yu Xia +3 more
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Cancer Cell, 2014 A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.
Sanchez-Gurmaches, Joan +1 more
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Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]
Open Biology, 2019 Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu +14 more
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Cell Stress, 2021 Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity ...
Constantinos Demetriades +2 more
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mTORC1 maintains metabolic balance [PDF]
Cell Research, 2015 Anticancer therapeutics aimed at the inhibition of mTORC1 activity shift metabolism to favor the degradation of extracellular proteins. Recently Thompson and colleagues demonstrated a novel regulatory mechanism whereby mTORC1 plays a distinct role as a key regulator of metabolism depending on the environmental nutrient status.
Heesun, Cheong, Daniel J, Klionsky
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Clinical and Experimental Hypertension, 2023 Background In-stent restenosis hardly limits the therapeutic effect of the percutaneous vascular intervention. Although the restenosis is significantly ameliorated after the application of new drug-eluting stents, the incidence of restenosis remains at a
Ke Peng +7 more
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Glutaminolysis Activates Rag-mTORC1 Signaling [PDF]
Molecular Cell, 2012 Amino acids control cell growth via activation of the highly conserved kinase TORC1. Glutamine is a particularly important amino acid in cell growth control and metabolism. However, the role of glutamine in TORC1 activation remains poorly defined. Glutamine is metabolized through glutaminolysis to produce α-ketoglutarate.
Durán, R. V. +6 more
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Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]
, 2018 Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid +14 more
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PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]
, 2019 Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F. +14 more
core +1 more source
médecine/sciences, 2013 mTOR (mammalian target of rapamycin), a protein kinase highly conserved, is the catalytic subunit of two complexes, mTORC1 and mTORC2. These complexes are regulated by amino acids availability, by insulin and growth factors signaling pathways. Thus, mTORC1 and mTORC2 complexes are essential sensors of the cellular nutrient and energy levels in living ...
Tartarin, Pauline, Froment, Pascal
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