Results 11 to 20 of about 63,525 (265)
A lipid off-switch for mTORC1 [PDF]
Molecular & Cellular Oncology, 2017 Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β ...
Alexander Wallroth, Volker Haucke
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MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1 [PDF]
Cell Reports, 2017 The mechanistic target of rapamycin (mTOR) integrates numerous stimuli and coordinates the adaptive response of many cellular processes. To accomplish this, mTOR associates with distinct co-factors that determine its signaling output. While many of these
Michael C. Brown, Matthias Gromeier
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Regulation of nuclear mTORC1 [PDF]
Molecular & Cellular Oncology, 2021 mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear ...
Xin Zhou, Yanghao Zhong, Jin Zhang
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MTORC1 and the Rebirth of Stemness [PDF]
Developmental Cell, 2020 MTORC1 activity is critical for tissue regeneration in multiple organs and contexts. In this issue of Developmental Cell, Miao et al. describe upstream regulators of mTORC1 activity which promote paligenosis, a process where mature cells de-differentiate to acquire stem cell activity in the face of injury.
Nicolette M, Johnson +1 more
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Regulation of adiposity by mTORC1 [PDF]
Einstein (São Paulo), 2017 ABSTRACT Obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. Therefore, its increasing prevalence is a public health concern, and it is important to better understand its etiology to develop new therapeutic strategies ...
Magdalon, Juliana +1 more
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Suppressing mTORC1 on the lysosome [PDF]
The EMBO Journal, 2017 The mechanistic target of rapamycin, mTOR, is a protein kinase that integrates environmental and nutritional inputs into regulation of cell growth and metabolism. Key outputs of mTOR signalling occur from the lysosome membrane in the form of the multi‐subunit mTOR complex 1 (mTORC1), which phosphorylates multiple targets. While class I phosphoinositide
Camilla Raiborg +2 more
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Glutaminolysis feeds mTORC1 [PDF]
Cell Cycle, 2012 Glutamine is an important amino acid from a metabolic point of view. As an amino acid and a precursor for other amino acids, it sustains protein synthesis. It is also required for production of nucleotides (pyrimidines) and α-ketoglutarate (αKG). αKG is produced via double deamination of glutamine, a process termed glutaminolysis. Glutamine is first de-
Durán, Raúl V., Hall, Michael N.
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Cell Cycle, 2012 A balance must be struck between cell growth and stress responses to ensure that cells proliferate without accumulating damaged DNA. This balance means that optimal cell proliferation requires the integration of pro-growth and stress-response pathways. mTOR (mechanistic target of rapamycin) is a pleiotropic kinase found in complex 1 (mTORC1).The mTORC1
Paul, Hasty +3 more
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Cancer Cell, 2014 A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.
Sanchez-Gurmaches, Joan +1 more
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Spatiotemporal feedforward between PKM2 tetramers and mTORC1 prompts mTORC1 activation
Physical Biology, 2022 Abstract Most mammalian cells couple glucose availability to anabolic processes via the mTORC1 pathway. However, the mechanism by which fluctuations in glucose availability are rapidly translated into mTORC1 signals remains elusive. Here, we show that cells rapidly respond to changes in glucose availability through the spatial coupling ...
Yu Xia +3 more
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