Results 11 to 20 of about 63,007 (266)
A lipid off-switch for mTORC1 [PDF]
Molecular & Cellular Oncology, 2017 Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β ...
Alexander Wallroth, Volker Haucke
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MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1 [PDF]
Cell Reports, 2017 The mechanistic target of rapamycin (mTOR) integrates numerous stimuli and coordinates the adaptive response of many cellular processes. To accomplish this, mTOR associates with distinct co-factors that determine its signaling output. While many of these
Michael C. Brown, Matthias Gromeier
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Regulation of nuclear mTORC1 [PDF]
Molecular & Cellular Oncology, 2021 mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear ...
Xin Zhou, Yanghao Zhong, Jin Zhang
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MTORC1 and the Rebirth of Stemness [PDF]
Developmental Cell, 2020 MTORC1 activity is critical for tissue regeneration in multiple organs and contexts. In this issue of Developmental Cell, Miao et al. describe upstream regulators of mTORC1 activity which promote paligenosis, a process where mature cells de-differentiate to acquire stem cell activity in the face of injury.
Nicolette M, Johnson +1 more
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COVID 19 in a family with rare genetic disease of the nervous system
Неврология, нейропсихиатрия, психосоматика, 2022 We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and ...
M. Yu. Martynov +2 more
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Cellular Uptake, Metabolism and Sensing of Long-Chain Fatty Acids
Frontiers in Bioscience-Landmark, 2023 Fatty acids (FAs) are critical nutrients that regulate an organism’s health and development in mammal. Long-chain fatty acids (LCFAs) can be divided into saturated and unsaturated fatty acids, depending on whether the carbon chain contains at least 1 ...
Qiburi He +4 more
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Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]
Open Biology, 2019 Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu +14 more
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Regulation of adiposity by mTORC1 [PDF]
Einstein (São Paulo), 2017 ABSTRACT Obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. Therefore, its increasing prevalence is a public health concern, and it is important to better understand its etiology to develop new therapeutic strategies ...
Magdalon, Juliana +1 more
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Suppressing mTORC1 on the lysosome [PDF]
The EMBO Journal, 2017 The mechanistic target of rapamycin, mTOR, is a protein kinase that integrates environmental and nutritional inputs into regulation of cell growth and metabolism. Key outputs of mTOR signalling occur from the lysosome membrane in the form of the multi‐subunit mTOR complex 1 (mTORC1), which phosphorylates multiple targets.
Camilla Raiborg +2 more
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Clinical and Experimental Hypertension, 2023 Background In-stent restenosis hardly limits the therapeutic effect of the percutaneous vascular intervention. Although the restenosis is significantly ameliorated after the application of new drug-eluting stents, the incidence of restenosis remains at a
Ke Peng +7 more
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