Results 11 to 20 of about 20,473 (133)

Optical Aptamer Probes of Fluorescent Imaging to Rapid Monitoring of Circulating Tumor Cell

Sensors, 2016
Fluorescence detecting of exogenous EpCAM (epithelial cell adhesion molecule) or muc1 (mucin1) expression correlated to cancer metastasis using nanoparticles provides pivotal information on CTC (circulating tumor cell) occurrence in a noninvasive tool ...
Ji Yeon Hwang, Sang Tae Kim, Ho-Seong Han, Kyunggon Kim, Jin Soo Han   +4 more
doaj   +1 more source

Baseline immunity predicts prognosis of pancreatic cancer patients treated with WT1 and/or MUC1 peptide-loaded dendritic cell vaccination and a standard chemotherapy

Human Vaccines & Immunotherapeutics, 2021
The prognosis of patients with advanced pancreatic cancer is poor despite the recent introduction of immune checkpoint inhibitors. Therefore, the development of new therapeutic approaches is urgently required.
Shuichi Ota, Mamiko Miyashita, Yuka Yamagishi, Masahiro Ogasawara   +3 more
doaj   +1 more source

MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERα) in regulation of the MUC1 gene expression

Molecular Cancer, 2006
Background The MUC1 gene encodes a mucin glycoprotein(s) which is basally expressed in most epithelial cells. In breast adenocarcinoma and a variety of epithelial tumors its transcription is dramatically upregulated.
Wreschner Daniel H, Gorivodsky Marat, Aylon Yael, Barnea Itay, Zaretsky Joseph Z, Keydar Iafa   +5 more
doaj   +1 more source

Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS)

Türk Patoloji Dergisi, 2023
Objective: Lung adenocarcinomas are divided into acinar, lepidic, papillary, micropapillary, and solid predominant subtypes according to the current World Health Organization (WHO) classification.
Melek BUYUK, Yasemin OZLUK, Dogu VURALLI BAKKALOGLU, Berker OZKAN, Pinar FIRAT, Dilek YILMAZBAYHAN   +5 more
doaj   +1 more source

Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

mBio, 2022
Influenza A virus (IAV) causes significant morbidity and mortality in the human population. Tethered mucin 1 (MUC1) is highly expressed in airway epithelium, the primary site of IAV replication, and also by other cell types that influence IAV infection ...
Ethan Iverson, Kira Griswold, Daniel Song, Talita B. Gagliardi, Kajal Hamidzadeh, Mehmet Kesimer, Sanju Sinha, Melissa Perry, Gregg A. Duncan, Margaret A. Scull   +9 more
doaj   +1 more source

Molecular interactions between MUC1 epithelial mucin, β-catenin, and CagA proteins

Frontiers in Immunology, 2012
Interleukin (IL)-8-driven neutrophil infiltration of the gastric mucosa is pathognomonic of persistent Helicobacter pylori infection. Our prior study showed that ectopic over-expression of MUC1 in human AGS gastric epithelial cells reduced H.
Wei eGuang, William eTwadell, Erik eLillehoj   +2 more
doaj   +1 more source

The research status and prospects of MUC1 in immunology

Human Vaccines & Immunotherapeutics, 2023
In immune processes, molecular – molecular interactions are complex. As MUC1 often appears to be an important molecule in inflammation and tumor immunity, it is necessary to summarize the leading countries, authors, journals, and the cooperation among ...
Linna Long, Xueying Huang, Siying Yu, Jiahui Fan, Xia Li, Rong Xu, Xiaorui Zhang, He Huang   +7 more
doaj   +1 more source

MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.

PLoS Pathogens, 2009
The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H.
Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy H J Florin, Philip Sutton, Michael A McGuckin   +7 more
doaj   +1 more source

MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer

OncoImmunology, 2017
The cancer immune microenvironment is of importance for the effectiveness of immunotherapy; however, its dysregulation is poorly understood. The MUC1-C oncoprotein is aberrantly overexpressed in non-small cell lung cancer (NSCLC) and has been linked to ...
Audrey Bouillez, Dennis Adeegbe, Caining Jin, Xiufeng Hu, Ashujit Tagde, Maroof Alam, Hasan Rajabi, Kwok-Kin Wong, Donald Kufe   +8 more
doaj   +1 more source

MUC1 expression and anti-MUC1 serum immune response in head and neck squamous cell carcinoma (HNSCC): a multivariate analysis

BMC Cancer, 2006
Background HNSCC progression to adjacent tissue and nodes may be mediated by altered glycoproteins and glycolipids such as MUC1 mucin. This report constitutes a detailed statistical study about MUC1 expression and anti-MUC1 immune responses in relation ...
Segal-Eiras Amada, Pereyra Adrián, Croce María V, Rabassa Martín E   +3 more
doaj   +1 more source