Results 31 to 40 of about 39,306 (244)

The research status and prospects of MUC1 in immunology

Human Vaccines & Immunotherapeutics, 2023
In immune processes, molecular – molecular interactions are complex. As MUC1 often appears to be an important molecule in inflammation and tumor immunity, it is necessary to summarize the leading countries, authors, journals, and the cooperation among ...
Linna Long, Xueying Huang, Siying Yu, Jiahui Fan, Xia Li, Rong Xu, Xiaorui Zhang, He Huang   +7 more
doaj   +1 more source

Apocrine glands in the eyelid of primates contribute to the ocular host defense [PDF]

, 2004
Apocrine glands of Moll are regular components of primate eyelids. We studied the distribution and localization of these glands in three different primate species, the common marmoset, the rhesus monkey, and the hamadryas baboon.
Stoeckelhuber, B. M., Stoeckelhuber, M., Welsch, U.   +2 more
core   +1 more source

MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.

PLoS Pathogens, 2009
The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H.
Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy H J Florin, Philip Sutton, Michael A McGuckin   +7 more
doaj   +1 more source

The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization

Cell Death and Disease, 2022
Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can promote cancer. Oncoprotein mucin 1 (MUC1) targets mitochondria to attenuate drug-induced apoptosis.
Quanfu Li, Yunkai Chu, Shengze Li, Liping Yu, Huayun Deng, Chunhua Liao, Xiaodong Liao, Chihyu Yang, Min Qi, Jinke Cheng, Guoqiang Chen, Lei Huang   +11 more
doaj   +1 more source

Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

mBio, 2022
Influenza A virus (IAV) causes significant morbidity and mortality in the human population. Tethered mucin 1 (MUC1) is highly expressed in airway epithelium, the primary site of IAV replication, and also by other cell types that influence IAV infection ...
Ethan Iverson, Kira Griswold, Daniel Song, Talita B. Gagliardi, Kajal Hamidzadeh, Mehmet Kesimer, Sanju Sinha, Melissa Perry, Gregg A. Duncan, Margaret A. Scull   +9 more
doaj   +1 more source

Molecular interactions between MUC1 epithelial mucin, β-catenin, and CagA proteins

Frontiers in Immunology, 2012
Interleukin (IL)-8-driven neutrophil infiltration of the gastric mucosa is pathognomonic of persistent Helicobacter pylori infection. Our prior study showed that ectopic over-expression of MUC1 in human AGS gastric epithelial cells reduced H.
Wei eGuang, William eTwadell, Erik eLillehoj   +2 more
doaj   +1 more source

Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas [PDF]

, 2019
The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular ...
Alvaro, D, Arcidiacono, Pg, Capurso, G., Cardinale, V, Carpino, G, Doglioni, C, Gaudio, E, Pedica, F, Petrone, Mc, Severi, C, Zaccari, P   +10 more
core   +1 more source

MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer

OncoImmunology, 2017
The cancer immune microenvironment is of importance for the effectiveness of immunotherapy; however, its dysregulation is poorly understood. The MUC1-C oncoprotein is aberrantly overexpressed in non-small cell lung cancer (NSCLC) and has been linked to ...
Audrey Bouillez, Dennis Adeegbe, Caining Jin, Xiufeng Hu, Ashujit Tagde, Maroof Alam, Hasan Rajabi, Kwok-Kin Wong, Donald Kufe   +8 more
doaj   +1 more source

Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro. [PDF]

PLoS ONE, 2012
Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by the adverse effects of cytotoxic agents. Targeted drug delivery may reduce the non-specific toxicity of chemotherapy by selectively directing anticancer drugs to tumor ...
Yan Hu, Jinhong Duan, Qimin Zhan, Fengdan Wang, Xin Lu, Xian-Da Yang   +5 more
doaj   +1 more source

Mucin glycosylation and sulphation in airway epithelial cells is not influenced by cystic fibrosis transmembrane conductance regulator expression [PDF]

, 2005
Abnormalities in mucus properties and clearance make a major contribution to the pathology of cystic fibrosis (CF). Our aim was to test the hypothesis that the defects in CF mucus are a direct result of mutations in the CF transmembrane conductance ...
Dell, Anne, Evans, Joanne, Harris, Ann, Leir, Shih-Hsing, Morris, Howard R, Palmai-Pallag, Timea, Parry, Simon   +6 more
core   +1 more source