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MUC1: Antibodies and Immunoassays
Tumor Biology, 2001 High molecular weight mucins represent a unique challenge as tumor markers by virtue of their complex array of epitopes. The list is dominated by the high molecular weight mucins MUC1, CEA and CA125. While the currently accepted role for these tumor markers is in the prediction and detection of relapse, it is possible that their sensitivity and ...
Rye, Phil D., McGuckin, Michael A.
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MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice. [PDF]
, 2016 It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors. Employing clinically relevant mouse models, we ruled out such causes as irreversible T-cell tolerance ...
Vani Lakshminarayanan +47 more
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Optical Aptamer Probes of Fluorescent Imaging to Rapid Monitoring of Circulating Tumor Cell
Sensors, 2016 Fluorescence detecting of exogenous EpCAM (epithelial cell adhesion molecule) or muc1 (mucin1) expression correlated to cancer metastasis using nanoparticles provides pivotal information on CTC (circulating tumor cell) occurrence in a noninvasive tool ...
Ji Yeon Hwang +4 more
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Molecular Cancer, 2006 Background The MUC1 gene encodes a mucin glycoprotein(s) which is basally expressed in most epithelial cells. In breast adenocarcinoma and a variety of epithelial tumors its transcription is dramatically upregulated.
Wreschner Daniel H +5 more
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BMC Cancer, 2006 Background HNSCC progression to adjacent tissue and nodes may be mediated by altered glycoproteins and glycolipids such as MUC1 mucin. This report constitutes a detailed statistical study about MUC1 expression and anti-MUC1 immune responses in relation ...
Segal-Eiras Amada +3 more
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American Journal of Respiratory Cell and Molecular Biology, 2008 Abstract MUC1 is a membrane-tethered mucin expressed on the surface of epithelial cells lining mucosal surfaces. Recent studies have begun to elucidate the physiologic function of MUC1 in the airways, pointing to an antiinflammatory role that is initiated late in the course of bacterial infection and is mediated through inhibition of ...
K. Chul Kim, Erik P. Lillehoj
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PLoS Pathogens, 2009 The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H.
Sara K Lindén +7 more
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Cell Death and Disease, 2022 Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can promote cancer. Oncoprotein mucin 1 (MUC1) targets mitochondria to attenuate drug-induced apoptosis.
Quanfu Li +11 more
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mBio, 2022 Influenza A virus (IAV) causes significant morbidity and mortality in the human population. Tethered mucin 1 (MUC1) is highly expressed in airway epithelium, the primary site of IAV replication, and also by other cell types that influence IAV infection ...
Ethan Iverson +9 more
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MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer
OncoImmunology, 2017 The cancer immune microenvironment is of importance for the effectiveness of immunotherapy; however, its dysregulation is poorly understood. The MUC1-C oncoprotein is aberrantly overexpressed in non-small cell lung cancer (NSCLC) and has been linked to ...
Audrey Bouillez +8 more
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