Results 51 to 60 of about 39,306 (244)
New generation of electrochemical immunoassay based on polymeric nanoparticles for early detection of breast cancer [PDF]
, 2017 Screening and early diagnosis are the key factors for the reduction of mortality rate and treatment cost of cancer. Therefore, sensitive and selective methods that can reveal the low abundance of cancer biomarkers in a biological sample are always ...
Al-Hetlani, Entesar +5 more
core +1 more source
Scientific Reports, 2021 We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo.
Avelino C. Verceles +11 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti +27 more
wiley +1 more source
Epitope Characterization of MUC1 Antibodies
Tumor Biology, 1998 The specificities of the 56 MAbs submitted to the ISOBM TD-4 Workshop were characterized by ELISA assays against MUC1-positive (ZR75-1) and MUC1-negative cell lines (LS174T), binding to a 20-mer peptide corresponding to the tandem repeat region of MUC1 apoprotein, and Pepscan analysis of overlapping 9-mer peptides corresponding to the tandem repeat ...
A, Blockzjil, K, Nilsson, O, Nilsson
openaire +4 more sources
Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target. [PDF]
PLoS ONE, 2015 Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed in diverse human carcinomas and certain hematologic malignancies. The oncogenic MUC1 transmembrane C-terminal subunit (MUC1-C) functions in part by transducing growth and survival ...
Deepak Raina +7 more
doaj +1 more source
Pharmaceutics, 2023 Mucin-1 (MUC1) is a highly relevant antigen for cancer vaccination due to its overexpression and hypo-glycosylation in a high percentage of carcinomas. To enhance the immune response to MUC1, our group has developed C3-liposomes that encapsulate the MUC1
Ameneh Arabi +5 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane +4 more
wiley +1 more source
Latest developments in MUC1 immunotherapy [PDF]
Biochemical Society Transactions, 2018 Currently, there is renewed interest in attempting to recruit the host immune system to eliminate cancers, and within this renewed activity, MUC1 continues to arouse interest. MUC1 has been considered a possible therapeutic target for the past 30 years as it is up-regulated, aberrantly glycosylated and its polarization is lost in many adenocarcinomas ...
Taylor-Papadimitriou, Joyce +3 more
openaire +3 more sources
Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells [PDF]
, 2014 The capacity of breast cancer cells to form mammospheres in non-adherent serum-free culture is used as a functional characteristic of the self-renewing stem-like cell population.
Ahmad, Rehan +4 more
core +1 more source
Pharmaceutics, 2021 MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression.
Huma Khan +5 more
doaj +1 more source