Results 51 to 60 of about 28,581 (233)

Anti-MUC1 conjugation efficiency.

, 2015
(A) LSPR peak red shifting is observed with sequential BSA and anti-MUC1 modifications. (B) ELISA reveals total incorporation of MUC1-N and—C antibodies was achieved (* p < 0.05) only in PD-primed NRs additionally stabilized via a BSA layer.
Christina M. Fuentes (765788), Phillip B. Messersmith (765789), Daria C. Zelasko-Leon (765787)   +2 more
core   +1 more source

Molecular interactions between MUC1 epithelial mucin, β-catenin, and CagA proteins

Frontiers in Immunology, 2012
Interleukin (IL)-8-driven neutrophil infiltration of the gastric mucosa is pathognomonic of persistent Helicobacter pylori infection. Our prior study showed that ectopic over-expression of MUC1 in human AGS gastric epithelial cells reduced H.
Wei eGuang, William eTwadell, Erik eLillehoj   +2 more
doaj   +1 more source

MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells

Journal for ImmunoTherapy of Cancer, 2023
Background The MUC1-C protein evolved in mammals to protect barrier tissues from loss of homeostasis; however, MUC1-C promotes oncogenesis in association with chronic inflammation. Aberrant expression of MUC1-C in cancers has been linked to depletion and
Satoshi Ishikawa, Donald Kufe, Constantine Mitsiades, Nami Yamashita, Atsushi Fushimi, Atrayee Bhattacharya, Yoshihiro Morimoto, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky   +13 more
doaj   +1 more source

Detection of MUC1 SP on the membrane of MUC1-positive tumor cells.

, 2014
The cell surface presence and similarity analysis of the MUC1 SP domain and MUC1 TRA was evaluated on OVACAR-3 MUC1-positive and ES-2 MUC1-negative tumor cell lines by imagestream analysis using PE- and APC-tagged anti-MUC1 SP mAbs SPmAb-2.1, SPmAb-6 ...
Michael Y. Shapira (506809), Lior Carmon (506810), Galit Horn (506808), Nechama I. Smorodinsky (140867), Riva Kovjazin (506807)   +4 more
core   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice. [PDF]

, 2016
It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors. Employing clinically relevant mouse models, we ruled out such causes as irreversible T-cell tolerance ...
Vani Lakshminarayanan, Bradley, Judy M, Supekar, Nitin T, Kosiorek, Heidi E, Cathy S Madsen, Peter A Cohen, Nitin T. Supekar (846892), Gendler, Sandra J, Sub Algemeen Scheikunde, Madsen, Cathy S, Jie Wei (264772), Trivedi, Priyanka P, Dominique B. Hoelzinger (846898), Latha B. Pathangey (846897), Wei, Jie, Geert-Jan Boons (212062), Pathangey, Latha B, Peter A. Cohen (285698), Jie Wei, Hoelzinger, Dominique B, Dustin B McCurry, Amylou C. Dueck (289612), Dominique B Hoelzinger, Medicinal Chemistry and Chemical Biology, McCurry, Dustin B, Heidi E Kosiorek, Latha B Pathangey, Wolfert, Margreet A, Cohen, Peter A, Dustin B. McCurry (846893), Margreet A Wolfert, Sandra J. Gendler (846900), Amylou C Dueck, Margreet A. Wolfert (846899), Priyanka P. Trivedi (846895), Priyanka P Trivedi, Sub Chemical pharmacology, Geert-Jan Boons, Cathy S. Madsen (846896), Heidi E. Kosiorek (846894), Judy M Bradley, Lakshminarayanan, Vani, Nitin T Supekar, Judy M. Bradley (625966), Vani Lakshminarayanan (846891), Dueck, Amylou C, Sandra J Gendler, Boons, Geert-Jan, Pathangey Latha B., Kosiorek Heidi E., Dueck Amylou C., Boons Geert-Jan, Lakshminarayanan Vani, Trivedi Priyanka P., Cohen Peter A., Madsen Cathy S., Hoelzinger Dominique B., Bradley Judy M., Gendler Sandra J., Wei Jie, McCurry Dustin B., Wolfert Margreet A., Supekar Nitin T.   +62 more
core   +1 more source

Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric Cancer: From Surgical Specimens to Clinical Translation

Annals of Gastroenterological Surgery, EarlyView.
Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley   +1 more source

Generation of MUC1 SP-specific antibodies.

, 2014
The specificity and defined minimal epitope of the generated anti-MUC1 SP polyclonal antibodies (A–C) and mAbs SPmAb-2.1 and SPmAb-6 (D–E) were evaluated against the immunizing peptide MUC1-SP-M and its internal epitopes MUC1-SP-S1 to S5, in ELISA assays.
Michael Y. Shapira (506809), Lior Carmon (506810), Galit Horn (506808), Nechama I. Smorodinsky (140867), Riva Kovjazin (506807)   +4 more
core   +1 more source

Prevention of Inflammation-Driven Colon Carcinogenesis in Human MUC1 Transgenic Mice by Vaccination with MUC1 DNA and Dendritic Cells

, 2023
The preventive efficacy of MUC1-specific DNA immunization on inflammation-driven colon carcinogenesis in human MUC1 transgenic (MUC1.Tg) mice was investigated.
Retno Murwanti, Tatsuro Irimura, Kaoru Mogushi, Sandra J. Gendler, Daisuke Sugiura, Kaori Denda-Nagai, Denda-Nagai, Kaori, Murwanti, Retno, Mogushi, Kaoru, Irimura, Tatsuro, Gendler, Sandra J., Sugiura, Daisuke   +11 more
core   +1 more source

Knockdown of MUC1 by RNA Interference (siRNA) Influenced Vascular Endothelial Growth Factor Receptor (VEGFR2) and Suppression of Growth of Pancreatic Cancer Cells (PANC1) [PDF]

BIO Web of Conferences
MUC1 is overexpressed approximately in most of pancreatic adenocarcinomas and has been revealed to be linked with a worse prognosis, beside effectiveness, MUC1 hold for regulating cellular and developmental pathways. The objective of the current study is
Mohammed Taher Murtadha, Razzaq Hussein Ali   +1 more
doaj   +1 more source