Results 71 to 80 of about 28,581 (233)
JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination
Cancer Management and Research, 2020 Heng Zhang,1 Hui Zhao,2 Xiaolei He,3 Feng Xi,4 Jiwen Liu1 1School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Department of Radiation Therapy, Xinjiang Uygur Autonomous ...
Zhang H, Zhao H, He X, Xi F, Liu J
doaj
Scientific Reports, 2021 We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo.
Avelino C. Verceles +11 more
doaj +1 more source
Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley +1 more source
Desing of cancer vaccines based on MUC1-Like Glycopeptides Containing Non-Natural Amino Acids
, 2022 The Tn antigen (GalNAc-α-1-O-Thr) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides with this structure (e.g., mucin 1, MUC1) has become a promising field of research due to their potential use as cancer vaccines.[1 ...
Ó. Suárez +6 more
core
Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target. [PDF]
PLoS ONE, 2015 Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed in diverse human carcinomas and certain hematologic malignancies. The oncogenic MUC1 transmembrane C-terminal subunit (MUC1-C) functions in part by transducing growth and survival ...
Deepak Raina +7 more
doaj +1 more source
Organoid Coculture Models for Cancer Research and Immunotherapy
Med Research, EarlyView.This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang +9 more
wiley +1 more source
Latest developments in MUC1 immunotherapy [PDF]
Biochemical Society Transactions, 2018 Currently, there is renewed interest in attempting to recruit the host immune system to eliminate cancers, and within this renewed activity, MUC1 continues to arouse interest. MUC1 has been considered a possible therapeutic target for the past 30 years as it is up-regulated, aberrantly glycosylated and its polarization is lost in many adenocarcinomas ...
Taylor-Papadimitriou, Joyce +3 more
openaire +3 more sources
MUC1 and MUC2 mucins in flat and polypoid colorectal adenomas
, 1997 Aims - To examine the expression of MUC1 and MUC2 apomucins and distribution of MUC phenotypes (MUC2+/MUC1-, MUG2+/MUC1+, MUC2-/MUC1+, MUC2- /MUC1-) in colorectal tubular adenomas in order to compare the distribution of phenotypes in flat and polypoid ...
Ajioka, Y., Jass, J. R., Watanabe, H.
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VIEW, EarlyView.CA19‐9 and CA15‐3 measurements from seven contemporary immunoassay systems were compared using 464 and 499 native serum samples, respectively. Inter‐system correlations were higher for CA15‐3 than for CA19‐9, and only a limited number of systems met biological variation‐derived bias criteria.
Jia Li +10 more
wiley +1 more source
The chemotherapy resistance often leads to chemotherapy failure. This study aims to explore the molecular mechanism by which MUC1 regulates paclitaxel resistance in lung adenocarcinoma (LUAD), providing scientific basis for future target selection.
Hongyu Xu (3066969) +6 more
core +1 more source