Results 81 to 90 of about 21,265 (190)

Establishment of primary cell cultures from canine mammary gland malignant tumours: a preliminary study

Journal of Veterinary Research
Canine mammary gland cancer (CMGC) is the most common neoplastic condition in bitches and is often fatal. There are limited treatment options for CMGC. Primary cell cultures from mammary tumours are promising preclinical in vitro models in which to study
Petrouškova Patŕicia, Hudáková Nikola, Almášiová Viera, Valenčáková Alexandra, Horňáková L’ubica, Huniadi Mykhailo, Čížková Daša   +6 more
doaj   +1 more source

MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer

Biomedicines
Patients with pancreatic neuroendocrine tumors (pNETs) have limited access to effective targeted agents and invariably succumb to progressive disease. MUC1-C is a druggable oncogenic protein linked to driving pan-cancers. There is no known involvement of
Hiroki Ozawa, Naoki Haratake, Ayako Nakashoji, Tatsuaki Daimon, Atrayee Bhattacharya, Keyi Wang, Keisuke Shigeta, Atsushi Fushimi, Kazumasa Fukuda, Yohei Masugi, Ryo Yamaguchi, Minoru Kitago, Hirofumi Kawakubo, Yuko Kitagawa, Donald Kufe   +14 more
doaj   +1 more source

Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing

Life Science Alliance
A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.
Weiwei Peng, Koen CAP Giesbers, Marta Šiborová, J Wouter Beugelink, Matti F Pronker, Douwe Schulte, John Hilkens, Bert JC Janssen, Karin Strijbis, Joost Snijder   +9 more
doaj   +1 more source

Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection

iScience
Summary: Stenotrophomonas maltophilia (Sm), a multidrug-resistant pathogen often isolated from immunocompromised individuals, presents its flagellin to multimeric tandem repeats within the ectodomain of mucin-1 (MUC1-ED), expressed on airway epithelia ...
Erik P. Lillehoj, Yafan Yu, Avelino C. Verceles, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum   +6 more
doaj   +1 more source

Knockout of Mucin 1 inhibits the proliferation, migration, and invasion of human MDA-MB-231 cells by blocking autophagy flow. [PDF]

Braz J Med Biol Res
Huang Z, Zhao J, Zhang Q, Luo Y, Chen W, Liu Z, Liu X.   +6 more
europepmc   +1 more source

MUC1 Protects Preimplantation Embryos In Vitro via Clearance of ROS by Triggering Mitophagy. [PDF]

Cells
Yang J, Li D, Yang C, Deng H, Lin K, Liao B, Liao X, Liu Y, Lyu Q, Huang L.   +9 more
europepmc   +1 more source

Muc1 drives tendon regeneration by activating an endothelial-to-tenocyte PDGFA signaling axis via extracellular vesicles. [PDF]

Mater Today Bio
Xue Y, Sun J, Ji XH, Wang R, Shi JY, Yang QQ, Zhou YL, Tan J.   +7 more
europepmc   +1 more source

MUC1-targeting small peptide radiopharmaceuticals for breast cancer. [PDF]

EJNMMI Radiopharm Chem
Malek R, Landry M, Cheung P, Beinat C.
europepmc   +1 more source

Flow-cytometric profiling of large extracellular vesicles as immunophenotypic biomarkers in head and neck squamous cell carcinoma. [PDF]

Cancer Immunol Immunother
Büntzel J, Maulhardt M, Angleitner AC, Schulz M, Köberle D, Naser S, Zwerenz C, Pagel CF, Hille A, Hund AC, Büntzel J.   +10 more
europepmc   +1 more source

An in vitro approach for simulating divergent Golgi O-glycosylation of tumor-associated MUC1 from normal MUC1. [PDF]

Nat Commun
Nashed A, Dilsook K, Senapathi T, Naidoo KJ.   +3 more
europepmc   +1 more source