Results 81 to 90 of about 21,152 (196)

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Anodic Self‐Electrochemiluminescence of Carboxyl‐Functionalized Tetraphenylethylene Derivatives for SOD2 Detection

Aggregate, Volume 7, Issue 6, June 2026.
A novel self‐ECL mechanism of TPED‐(COOH)x aggregates is proposed, involving oxidation and disproportionation to form excited states. The H4TCTPE‐labeled antibody enables sensitive detection of SOD2. ABSTRACT The self‐electroluminescent (self‐ECL) behaviors of tetraphenylethylene carboxyl derivatives (TPED‐(COOH)x) during the anodic process are first ...
Zuoxun Xie, Bangxiang Liu, Runying He, Qiang Yu, Xiurong Ma, Yunming Liu, Xinye Cao, Qiue Cao, Liyan Zheng   +8 more
wiley   +1 more source

Affinity of Antibodies to MUC1 Antigens

Tumor Biology, 1998
The binding affinity of a monoclonal antibody to its ligand has been often used as a qualitative and quantitative measure for the specificity of the antibody. The aim of this paper was to assess the affinity of binding to recombinant and synthetic MUC1 peptides of 52 monoclonal antibodies as part of the ISOBM TD-4 Workshop.
V, Karanikas, K, Patton, G, Jamieson, G, Pietersz, I, McKenzie   +4 more
openaire   +2 more sources

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

Host immune collapse in influenza‐associated pulmonary aspergillosis: From barrier dysfunction to metabolic paralysis

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
From barrier dysfunction to metabolic paralysis: IAPA progression is characterized by a functional dissociation: the host experiences hyper‐inflammatory cytokine storms (IL‐1β, IFN‐λ) while simultaneously suffering from antimicrobial metabolic paralysis (loss of ROS and recognition). This creates a specific window for host‐directed therapies, including
Liangyu Li, Shuo Liang
wiley   +1 more source

MUC1 in cancer

Holistic Integrative Oncology
Abstract Mucin 1 (MUC1), a prototypical transmembrane mucin, is aberrantly overexpressed and hypoglycosylated in a broad spectrum of epithelial malignancies and hematologic cancers, with its expression level closely correlated with tumor proliferation, metastatic invasion, therapeutic resistance, and poor patient prognosis.
Ke Qian, Yiting Zhang, Qingyu Zhou, Jianming Zhou, Xiang Wu, Jiajun Zhu, Yinchen Pan, Zuyao Wu, Shaomin Li, Yong Lin, Feizhou Lyu, Shuying Chen, Huichuan Sun   +12 more
openaire   +1 more source

Pancreatic Adenocarcinoma: Diagnosis by Ultrasound‐Guided Fine‐Needle Aspiration—Cyto‐Histological Correlation and Experience at a Multidisciplinary Tertiary Reference Center

Diagnostic Cytopathology, Volume 54, Issue 6, Page 403-416, June 2026.
ABSTRACT Background Pancreatic adenocarcinoma (PDAC) is characterized by its poor prognosis. Cytology is essential for diagnostic confirmation and ancillary studies. The endoscopic ultrasound (EUS) set a precedent, facilitating cytological sampling through fine‐needle aspiration (FNA), with a sensitivity of 93% and a specificity of 95%.
Judith González‐López, Mónica Elizabeth Bauza, Judith Pérez‐Rojas, Cecilia López‐Valdivia, Carlos Zac Romero, Óscar Castells‐Perona, Cristina Ballester‐Ibáñez, Eva Montalvá‐Orón, Rafael López‐Andújar, Lidia Argüello‐Viudez, Mireya Prieto Rodríguez   +10 more
wiley   +1 more source

Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection

The Saudi Journal of Gastroenterology, 2018
Background/Aim: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection.
Zhi-Gang Sun, Li Yu, Wei Gao, Zhou Wang, Liang-Ming Zhu   +4 more
doaj   +1 more source