Results 81 to 90 of about 28,581 (233)
EGF enhances nuclear localization of MUC1 by regulating its cleavage.
, 2012 (a) Immunoblot detecting MUC1 cytoplasmic domain showing increased levels of cleavage product with EGF treatment in whole-cell lysates from FG cells. (b) Representative images of immunofluorescence of MUC1.FL and MUC1.CD fused to GFP (MUC1.FL.GFP and ...
Jay S. Desgrosellier (166176) +11 more
core +1 more source
Computer simulation of the spatial structure of MUC 1 peptides capable of inhibiting apoptosis
Вавиловский журнал генетики и селекции, 2016 Identification of new effective inhibitors of apoptosis is an important task for drug development for treatment of a number diseases including neurogenerative diseases.
N. V. Ivanisenko +2 more
doaj +1 more source
Allergy, EarlyView.This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva +7 more
wiley +1 more source
PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells
OncoImmunology, 2017 In recent years, immunotherapies, such as those involving chimeric antigen receptor (CAR) T cells, have become increasingly promising approaches to non-small-cell lung cancer (NSCLC) treatment.
Xinru Wei +19 more
doaj +1 more source
Animals, 2020 Mucin 1 (MUC1), a transmembrane protein, is closely associated with the malignancy and metastasis of canine mammary tumors; however, the role of overexpressed MUC1 in the development of cancer cells and response to drug treatment remains unclear.
Ying Zhao +7 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
wiley +1 more source
Anti-MUC1 SP antibodies bind MUC1-expressing MM cells in fresh human BM aspirates.
, 2014 The cell surface presence of the MUC1 SP domain was evaluated by gated FACS analysis on PC cells in fresh BM aspirates obtained from MM patients (A–E) and normal naïve sample (F–H).
Michael Y. Shapira (506809) +4 more
core +1 more source
Cancer Science, EarlyView.Targeted triggering of SORL1 expression through a novel MPOC delivery system could inhibit ccRCC progression through binding to TRIM22 and further promoting ubiquitination‐mediated C‐MYC degradation, thereby facilitating the inhibition of oxidative phosphorylation through transcriptional repression of ACO2 and IDH2.
Keyi Wang +11 more
wiley +1 more source
Non‐natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity [PDF]
Glycopeptides derived from the glycoprotein mucin-1 (MUC1) have shown potential as tumor-associated antigens for cancer vaccine development. However, their low immunogenicity and non-selective conjugation to carriers present significant challenges for ...
Lazaris, Foivos S. [0000-0003-4292-8723] +8 more
core +1 more source
Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential
Clinical &Experimental Allergy, EarlyView.Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole +4 more
wiley +1 more source