Results 61 to 70 of about 21,265 (190)

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, Volume 159, Issue 5, Page 1296-1310, 1 September 2026.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination

Cancer Management and Research, 2020
Heng Zhang,1 Hui Zhao,2 Xiaolei He,3 Feng Xi,4 Jiwen Liu1 1School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Department of Radiation Therapy, Xinjiang Uygur Autonomous ...
Zhang H, Zhao H, He X, Xi F, Liu J
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, Volume 20, Issue 8, Page 2085-2101, August 2026.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Computer simulation of the spatial structure of MUC 1 peptides capable of inhibiting apoptosis

Вавиловский журнал генетики и селекции, 2016
Identification of new effective inhibitors of apoptosis is an important task for drug development for treatment of a number diseases including neurogenerative diseases.
N. V. Ivanisenko, I. N. Lavrik, V. A. Ivanisenko   +2 more
doaj   +1 more source

Gold Nano Biosensing Technologies for Early Breast Cancer Diagnosis: Recent Progress and Future Perspectives

Advanced Sensor Research, Volume 5, Issue 8, August 2026.
Overview of gold nanomaterial‐based biosensing strategies for early breast cancer diagnosis. The figure illustrates the detection of multiple biomarker classes, including proteins, nucleic acids, circulating tumor cells (CTCs), and exosomes from biological samples such as blood, serum, and cell lysates using electrochemical, SPR, SERS, fluorescence ...
Akanksha Pawar, Muskan Leharwani, Deena Mohammed Bukhary, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar, Prashant Kesharwani   +6 more
wiley   +1 more source

PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells

OncoImmunology, 2017
In recent years, immunotherapies, such as those involving chimeric antigen receptor (CAR) T cells, have become increasingly promising approaches to non-small-cell lung cancer (NSCLC) treatment.
Xinru Wei, Yunxin Lai, Jin Li, Le Qin, Youdi Xu, Ruocong Zhao, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Muyun Peng, Fenglei Yu, Yangqiu Li, Xuchao Zhang, Yilong Wu, Pentao Liu, Duanqing Pei, Yao Yao, Peng Li   +19 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Microfluidic nanochips for rapid exosome isolation and multiplex biomarker profiling from a single blood drop: Toward sample‐to‐answer liquid biopsy

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
A microfluidic nanodevice that analyses a single volume droplet of whole blood (10–50 microlitres (µL)) forms a fast and fully integrated exosome‐derived liquid biopsy. The closed system architecture involves plasma separation on chip, exosome enrichment by immunoaffinity and various size based, electrokinetic, acoustofluidic or hybridized strategies ...
Daniel Ejim Uti, Esther Ugo Alum, Josephine E. Egbung, Waheeb Sami Aggad, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Manpreet Kaur, Kranti Kiran Reddy Ealla   +7 more
wiley   +1 more source

SDCBP Cooperates With YBX1 to Promote ESCC Metastasis by Forming a Positive Feedback Loop With Wnt‐β‐Catenin Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
SDCBP interacted and cooperated with YBX1 to activate the Wnt/β‐catenin signaling pathway. Then, the activated Wnt/β‐catenin pathway targeted and induced the expression of SDCBP and other oncoproteins. The positive feedback loop between SDCBP and the Wnt/β‐catenin pathway accelerated the ESCC EMT process and promoted tumor metastasis. ABSTRACT Syndecan
Ruijuan Du, Bo Bian, Manyu Luo, Chen Yuan, Kelei Guo, Kai Li, Hui Zhang, Guangji Zhang, Li Han   +8 more
wiley   +1 more source