Results 61 to 70 of about 28,581 (233)

Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse

OncoImmunology, 2020
Therapeutic cancer vaccines aim to induce an effective immune response against cancer, and the effectiveness of these vaccines is influenced by the choice of immunogen, vaccine type, and immunization strategy.
Qianqian Guo, Lizheng Wang, Ping Xu, Fei Geng, Jie Guo, Ling Dong, Xin Bao, Yi Zhou, Mengfan Feng, Jiaxin Wu, Hui Wu, Bin Yu, Haihong Zhang, Xianghui Yu, Wei Kong   +14 more
doaj   +1 more source

Mouse cell lines transfected with human MUC1 DNA express MUC1-ARF.

, 2016
(A, and C) DA3 cells transfected with MUC1 cDNA; (B) DA3 cells transfected with human MUC1 genomic DNA, and (D) non-transfected mouse parental DA3 cells were immunostained with anti MUC1-ARF monoclonal antibody MPR2G10 followed by red-labeled secondary ...
John Hilkens (412442), Michael Chalick (3234639), Franz-Georg Hanisch (318572), Armand Bensussan (214677), Oded Jacobi (3234645), Nechama I. Smorodinsky (140867), Tania Zehavi (367263), Ravit Ziv (3234648), Christian Garbar (3234657), Alan Meeker (3234642), Daniel H. Wreschner (3234654), Edward Pichinuk (3234651), Daniel B. Rubinstein (3234636)   +12 more
core   +1 more source

Exploring Programmed Cell Death-Related Biomarkers and Disease Therapy Strategy in Nasopharyngeal Carcinoma Using Transcriptomics

Frontiers in Bioscience-Landmark
Background: Uncontrolled cellular proliferation may result in the progression of diseases such as cancer that promote organism death. Programmed cell death (PCD) is an important mechanism that ensures the quality and quantity of cells, which could be ...
Jiangyu Yan, Linrong Wu, Mengmeng Zheng, Fangfang Pan   +3 more
doaj   +1 more source

Differential expression of the glycosylated forms of MUC1 during lung development

European Journal of Histochemistry, 2009
Human MUC1 mucin is a high-molecular weight transmembrane glycoprotein expressed on the apical surface of the simple epithelia of many different tissues.
J Sakurai, N Hattori, M Nakajima, T Moriya, T Suzuki, A Yokoyama, N Kohno   +6 more
doaj   +1 more source

Enhancing T Cell and Antibody Response in Mucin-1 Transgenic Mice through Co-Delivery of Tumor-Associated Mucin-1 Antigen and TLR Agonists in C3-Liposomes

Pharmaceutics, 2023
Mucin-1 (MUC1) is a highly relevant antigen for cancer vaccination due to its overexpression and hypo-glycosylation in a high percentage of carcinomas. To enhance the immune response to MUC1, our group has developed C3-liposomes that encapsulate the MUC1
Ameneh Arabi, Shahab Aria (Soltani), Brandon Maniaci, Kristine Mann, Holly Martinson, Max Kullberg   +5 more
doaj   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Comparison of Stress‐Mediated Vocal Fold Epithelial Effects in Conventionally‐Raised and Germ‐Free Mice

The Laryngoscope, EarlyView.
The overarching aim of our study is to compare vocal fold epithelial changes in conventionally raised and germ‐free mice allotted to stressed and control groups. ABSTRACT Introduction Up to 25% of patients with voice disorders report concurrent psychosocial stress, which has been shown to cause laryngeal microbiome dysbiosis.
Anumitha Venkatraman, Katelyn Jacobs, Susan L. Thibeault   +2 more
wiley   +1 more source

MUC1 Makes Me Miserable [PDF]

Journal of the American Society of Nephrology, 2018
Monogenic diseases make an important contribution to the overall burden of kidney disease– accounting for well in excess of 10% of people needing renal replacement therapy. In this setting an accurate diagnosis is advantageous because it can provide prognostic information for the patient ...
Daniel P. Gale, Robert Kleta
openaire   +3 more sources

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Supplemental Figure 2: Characterization of MUC1-DG75 transfectant cell line and of the MUC1-DG75-MVs. from Microvesicle Cargo of Tumor-Associated MUC1 to Dendritic Cells Allows Cross-presentation and Specific Carbohydrate Processing

, 2014
A, MUC1 glycoform expression of MUC1-DG75 transfectant detected by flow cytometry employing anti-MUC1 glycoform specific MoAbs. Only the ST-MUC1 glycoform, (MoAb MYE12), is expressed on the surface of transfectant cells.
Morena Antonilli (15111665), Marianna Nuti (765801), Chiara Napoletano (765803), Hassan Rahimi (765799), Pierluigi Benedetti Panici (532476), Federico Battisti (765798), Francesca Belleudi (233982), Aurelia Rughetti (765802), Mara R. Torrisi (15111668), Filippo Bellati (532475), Hans H. Wandall (117287), Ilaria G. Zizzari (15111662), Joy M. Burchell (7957862)   +12 more
core   +1 more source