Results 41 to 50 of about 21,152 (196)
Journal of Dental Sciences, 2023 Background/purpose: Salivary gland cancer (SGC) is the common malignant tumor of the head and neck region with poor prognosis. Mucin 1 (MUC1) has been reported to be associated with the development of cancer.
Hao Lu +4 more
doaj +1 more source
Journal of the American Society of Nephrology, 2018 Monogenic diseases make an important contribution to the overall burden of kidney disease– accounting for well in excess of 10% of people needing renal replacement therapy. In this setting an accurate diagnosis is advantageous because it can provide prognostic information for the patient ...
Daniel P. Gale, Robert Kleta
openaire +3 more sources
Functional site analysis of mucin 1 in regulating the malignant characteristics of tumor cells
Shanghai Jiaotong Daxue xuebao. Yixue banObjective·To identify the functional motifs of mucin 1 (MUC1) involved in regulating tumor cell proliferation, migration, and stemness maintenance.Methods·Mutational characteristics of the MUC1 gene across different cancers were identified from The ...
GAO Kexing +4 more
doaj +1 more source
Regulation of Mucin 1 and multidrug resistance protein 1 by Neuraminidase 1 alters the cytotoxic effects of doxorubicin in breast cancer cells [PDF]
World Cancer Research JournalObjective: Elevated expression of Multidrug Resistance Protein 1 (MRP1) has been associated with poor prognosis among breast cancer patients. Chemotherapeutic drugs such as doxorubicin (DOX) are substrates of MRP1 that efflux the drug, conferring drug ...
P. Thulasiraman, K. Kerr, A. Wistner
doaj +1 more source
Scientific Reports, 2021 We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo.
Avelino C. Verceles +11 more
doaj +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Pharmaceutics, 2023 Mucin-1 (MUC1) is a highly relevant antigen for cancer vaccination due to its overexpression and hypo-glycosylation in a high percentage of carcinomas. To enhance the immune response to MUC1, our group has developed C3-liposomes that encapsulate the MUC1
Ameneh Arabi +5 more
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Advanced Materials Technologies, EarlyView.This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane +4 more
wiley +1 more source
Pharmaceutics, 2021 MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression.
Huma Khan +5 more
doaj +1 more source
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source