Results 41 to 50 of about 28,581 (233)

The Therapeutic Effects of MUC1-C shRNA@Fe3O4 Magnetic Nanoparticles in Alternating Magnetic Fields on Triple-Negative Breast Cancer

International Journal of Nanomedicine, 2023
Zhifeng Li,1,2 Ting Guo,3 Susu Zhao,4 Mei Lin2 1Medical School of Nantong University, Nantong, Jiangsu, People’s Republic of China; 2Clinical Laboratory, Taizhou People’s Hospital (Affiliated Hospital 5 of Nantong University), Taizhou, Jiangsu, People’s ...
Li Z, Guo T, Zhao S, Lin M
doaj  

MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERα) in regulation of the MUC1 gene expression

Molecular Cancer, 2006
Background The MUC1 gene encodes a mucin glycoprotein(s) which is basally expressed in most epithelial cells. In breast adenocarcinoma and a variety of epithelial tumors its transcription is dramatically upregulated.
Wreschner Daniel H, Gorivodsky Marat, Aylon Yael, Barnea Itay, Zaretsky Joseph Z, Keydar Iafa   +5 more
doaj   +1 more source

Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro. [PDF]

PLoS ONE, 2012
Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by the adverse effects of cytotoxic agents. Targeted drug delivery may reduce the non-specific toxicity of chemotherapy by selectively directing anticancer drugs to tumor ...
Yan Hu, Jinhong Duan, Qimin Zhan, Fengdan Wang, Xin Lu, Xian-Da Yang   +5 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Immunohistochemical analyses of MUC1-TM and MUC1-ARF expression in breast and pancreatic cancer.

, 2016
(A) Serial sections of breast cancer tissues from three distinct individuals were immunohistochemically stained with anti-MUC1-TM antibodies (anti-MUC1-TM [DMB5F3]), anti-MUC1-ARF antibodies (anti-MUC1-ARF [MPR2G10]) and with hematoxylin/eosin (H and E).
John Hilkens (412442), Michael Chalick (3234639), Franz-Georg Hanisch (318572), Armand Bensussan (214677), Oded Jacobi (3234645), Nechama I. Smorodinsky (140867), Tania Zehavi (367263), Ravit Ziv (3234648), Christian Garbar (3234657), Alan Meeker (3234642), Daniel H. Wreschner (3234654), Edward Pichinuk (3234651), Daniel B. Rubinstein (3234636)   +12 more
core   +1 more source

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Advanced Science, EarlyView.
Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee   +13 more
wiley   +1 more source

Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Vaccine, 2000
Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8(+) cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection ...
Lees, Catherine, Apostolopoulos, Vasso, Acres, Bruce, Ramshaw, Ian, Ramsay, Alistair, Ong, Cheng Soon, McKenzie, Ian F C   +6 more
openaire   +2 more sources

In vitro translation of MUC1 mRNA yields both MUC1-TM protein and MUC1-ARF protein.

, 2016
(A) RNAs transcribed from MUC1 cDNA [comprising a single 60 nucleotide (20 amino acid) repeat unit] cut with HindIII, PvuII, BalI, PstI or AccI (H, Pv, B, Ps and A, lanes 1–5 respectively, see Fig 1D and E) were translated in vitro with [35S]-methionine ...
John Hilkens (412442), Michael Chalick (3234639), Franz-Georg Hanisch (318572), Armand Bensussan (214677), Oded Jacobi (3234645), Nechama I. Smorodinsky (140867), Tania Zehavi (367263), Ravit Ziv (3234648), Christian Garbar (3234657), Alan Meeker (3234642), Daniel H. Wreschner (3234654), Edward Pichinuk (3234651), Daniel B. Rubinstein (3234636)   +12 more
core   +1 more source

MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.

PLoS Pathogens, 2009
The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H.
Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy H J Florin, Philip Sutton, Michael A McGuckin   +7 more
doaj   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source