Results 41 to 50 of about 39,306 (244)

MUC1 modulates gastric epithelial immune response to bacteria or inflammatory stimuli

Universa Medicina, 2015
BACKGROUND Cell surface mucin glycoproteins are expressed on the mucosal surface. One of these cell surface mucins is mucin-1 (MUC1), which plays a role as a physical barrier and limits inflammation.
Shofyatul Y. Triyana, Yong H. Sheng, Michael McGuckin   +2 more
doaj   +1 more source

MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells

Journal for ImmunoTherapy of Cancer, 2023
Background The MUC1-C protein evolved in mammals to protect barrier tissues from loss of homeostasis; however, MUC1-C promotes oncogenesis in association with chronic inflammation. Aberrant expression of MUC1-C in cancers has been linked to depletion and
Satoshi Ishikawa, Donald Kufe, Constantine Mitsiades, Nami Yamashita, Atsushi Fushimi, Atrayee Bhattacharya, Yoshihiro Morimoto, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky   +13 more
doaj   +1 more source

The Role of the Mucus Barrier in Digestion [PDF]

, 2012
Mucus forms a protective layer across a variety of epithelial surfaces. In the gastrointestinal (GI) tract, the barrier has to permit the uptake of nutrients, while excluding potential hazards, such as pathogenic bacteria.
A Macierzanka, AP Corfield, C Atuma, C Taylor, CT Nordgard, D Ambort, DJ Thornton, FJO Varum, G Maconi, G Patsos, G Spaeth, GC Hansson, GJ Besseris, J Celli, J Dekker, J McRorie, J Perez-Vilar, J Petersson, J Schwarz-Linek, JK Sheehan, JL McAuley, JM Barrios, JMH Larsson, K Godl, L Laine, L Marciani, L Marciani, LA Sellers, MA McGuckin, ME Johansson, ME Lidell, MEV Johansson, MEV Johansson, N Asker, RA Cone, RC Sprong, S Mukhopadhyay, S Vaishnava, SK Lai, SK Lai, SK Lai, TA Lang, Y Komiyama, YH Sheng   +43 more
core   +1 more source

MUC1: Antibodies and Immunoassays

Tumor Biology, 2001
High molecular weight mucins represent a unique challenge as tumor markers by virtue of their complex array of epitopes. The list is dominated by the high molecular weight mucins MUC1, CEA and CA125. While the currently accepted role for these tumor markers is in the prediction and detection of relapse, it is possible that their sensitivity and ...
Rye, Phil D., McGuckin, Michael A.
openaire   +3 more sources

MUC1 immunotherapy against a metastatic mammary adenocarcinoma model: Importance of IFN-gamma [PDF]

, 2016
Immunotherapy using mucin 1 (MUC1) linked to oxidised mannan (MFP) was investigated in an aggressive MUC1+ metastatic tumour, DA3-MUC1 because, unlike many MUC1+ tumour models, DA3-MUC1 is not spontaneously rejected in mice making it an alternative model
Apostolopoulos, Vasso, Horn, G, Lees, CJ, McKenzie, IFC, Pietersz, G, Smorodinsky, N, Stojanovska, Lily, Wreschner, DH   +7 more
core   +1 more source

TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS [PDF]

, 2015
Patients with HER2 positive breast cancer often exhibit intrinsic or acquired resistance to trastuzumab treatment. The transmembrane MUC1-C oncoprotein is aberrantly overexpressed in breast cancer cells and associates with HER2.
Baselga, Jose, Jin, Caining, Kharbanda, Akriti, Kharbanda, Surender, Kufe, Donald, Panchamoorthy, Govind, Raina, Deepak, Rajabi, Hasan, Scaltriti, Maurizio, Uchida, Yasumitsu   +9 more
core   +1 more source

Mucin 1 promotes salivary gland cancer cell proliferation and metastasis by regulating the epidermal growth factor receptor signaling pathway

Journal of Dental Sciences, 2023
Background/purpose: Salivary gland cancer (SGC) is the common malignant tumor of the head and neck region with poor prognosis. Mucin 1 (MUC1) has been reported to be associated with the development of cancer.
Hao Lu, Wan-Lin Xu, Yi-Fan Wu, Wen-Jun Yang, Sheng-Wen Liu   +4 more
doaj   +1 more source

Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells [PDF]

, 2014
Mucin 1 (MUC1) is overexpressed in various cancer cells especially in breast cancer cells. There are known research works on the use of anti-MUC1 antibody with docetaxel in ovarian cancer, but there are no data about combined therapy platinum compounds ...
Agnieszka Gornowicz, Anna Bielawska, Halina Gabryel-Porowska, Krzysztof Bielawski, Robert Czarnomysy, Zbigniew Kałuża   +5 more
core   +1 more source

Functional site analysis of mucin 1 in regulating the malignant characteristics of tumor cells

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To identify the functional motifs of mucin 1 (MUC1) involved in regulating tumor cell proliferation, migration, and stemness maintenance.Methods·Mutational characteristics of the MUC1 gene across different cancers were identified from The ...
GAO Kexing, LIAO Chunhua, LI Shengze, MA Shuangyu, HUANG Lei   +4 more
doaj   +1 more source

Regulation of Mucin 1 and multidrug resistance protein 1 by Neuraminidase 1 alters the cytotoxic effects of doxorubicin in breast cancer cells [PDF]

World Cancer Research Journal
Objective: Elevated expression of Multidrug Resistance Protein 1 (MRP1) has been associated with poor prognosis among breast cancer patients. Chemotherapeutic drugs such as doxorubicin (DOX) are substrates of MRP1 that efflux the drug, conferring drug ...
P. Thulasiraman, K. Kerr, A. Wistner
doaj   +1 more source