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The research status and prospects of MUC1 in immunology
Human Vaccines & Immunotherapeutics, 2023 In immune processes, molecular – molecular interactions are complex. As MUC1 often appears to be an important molecule in inflammation and tumor immunity, it is necessary to summarize the leading countries, authors, journals, and the cooperation among ...
Linna Long +7 more
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Cell Death and Disease, 2022 Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can promote cancer. Oncoprotein mucin 1 (MUC1) targets mitochondria to attenuate drug-induced apoptosis.
Quanfu Li +11 more
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BMC Cancer, 2006 Background HNSCC progression to adjacent tissue and nodes may be mediated by altered glycoproteins and glycolipids such as MUC1 mucin. This report constitutes a detailed statistical study about MUC1 expression and anti-MUC1 immune responses in relation ...
Segal-Eiras Amada +3 more
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mBio, 2022 Influenza A virus (IAV) causes significant morbidity and mortality in the human population. Tethered mucin 1 (MUC1) is highly expressed in airway epithelium, the primary site of IAV replication, and also by other cell types that influence IAV infection ...
Ethan Iverson +9 more
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MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer
OncoImmunology, 2017 The cancer immune microenvironment is of importance for the effectiveness of immunotherapy; however, its dysregulation is poorly understood. The MUC1-C oncoprotein is aberrantly overexpressed in non-small cell lung cancer (NSCLC) and has been linked to ...
Audrey Bouillez +8 more
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MUC1 modulates gastric epithelial immune response to bacteria or inflammatory stimuli
Universa Medicina, 2015 BACKGROUND Cell surface mucin glycoproteins are expressed on the mucosal surface. One of these cell surface mucins is mucin-1 (MUC1), which plays a role as a physical barrier and limits inflammation.
Shofyatul Y. Triyana +2 more
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Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro. [PDF]
PLoS ONE, 2012 Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by the adverse effects of cytotoxic agents. Targeted drug delivery may reduce the non-specific toxicity of chemotherapy by selectively directing anticancer drugs to tumor ...
Yan Hu +5 more
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Steroidal but not embryonic regulation of mucin 1 expression in bovine endometrium
The Journal of Reproduction and Development, 2021 In cow herd management, inadequate embryo implantation leads to pregnancy loss and causes severe economic losses. Thus, it is crucial to understand the molecular mechanisms underlying endometrial receptivity and subsequent embryo implantation ...
Kaiyu KUBOTA +4 more
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American Journal of Respiratory Cell and Molecular Biology, 2008 Abstract MUC1 is a membrane-tethered mucin expressed on the surface of epithelial cells lining mucosal surfaces. Recent studies have begun to elucidate the physiologic function of MUC1 in the airways, pointing to an antiinflammatory role that is initiated late in the course of bacterial infection and is mediated through inhibition of ...
K. Chul Kim, Erik P. Lillehoj
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Functional site analysis of mucin 1 in regulating the malignant characteristics of tumor cells
Shanghai Jiaotong Daxue xuebao. Yixue banObjective·To identify the functional motifs of mucin 1 (MUC1) involved in regulating tumor cell proliferation, migration, and stemness maintenance.Methods·Mutational characteristics of the MUC1 gene across different cancers were identified from The ...
GAO Kexing +4 more
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