Results 21 to 30 of about 27,684 (225)
MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization. [PDF]
PLoS ONE, 2012 BACKGROUND:MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells including pancreatic cancer. The cytosolic end of MUC1 (MUC1-c) is extensively involved in a number of signaling pathways.
Sulagna Banerjee +7 more
doaj +1 more source
A Droplet-Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients' Blood Plasma Samples. [PDF]
SmallThis study presents a droplet‐microarray platform integrated with a DNase I‐assisted MoS2 FRET aptasensor for multiplexed profiling of breast cancer subtypes’ exosomes from patients’ plasma. By targeting HER2, MUC1, and CD44, the system enables sensitive detection and accurate discrimination of luminal A, HER2‐positive, and triple‐negative subtypes ...
Liu Y +9 more
europepmc +2 more sources
MUC1 and endometrial receptivity [PDF]
Molecular Human Reproduction, 1998 Mucins, best known as the major constituent of mucus, are a family of highly glycosylated, high molecular weight (> or = 200 kDa) glycoproteins present on the surface of human epithelial cells. MUC1 has the features of an integral membrane protein. It has an extracellular tandem repeat domain that forms the major part of the core protein, and results ...
M, Meseguer, A, Pellicer, C, Simón
openaire +2 more sources
Human Vaccines & Immunotherapeutics, 2021 The prognosis of patients with advanced pancreatic cancer is poor despite the recent introduction of immune checkpoint inhibitors. Therefore, the development of new therapeutic approaches is urgently required.
Shuichi Ota +3 more
doaj +1 more source
MUC1 promotes the proliferation and invasion of lung cancer cells by regulating PI3K/AKT pathway. [PDF]
J Cardiothorac SurgMucin 1 (MUC1) has been found to be significantly up-regulated in various types of cancer. However, the precise role and underlying mechanisms of MUC1 in lung cancer remain elusive.
Liu Y, Lv Z.
europepmc +2 more sources
The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma [PDF]
, 2007 Aims: To clarify MUC1 patterns in invasive ductal breast carcinoma and to relate them to clinicopathological parameters, coexpression of other biological markers and prognosis.
de Bock, G. H. +10 more
core +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1999 The MUC1 membrane mucin was first identified as the molecule recognised by mouse monoclonal antibodies directed to epithelial cells, and the cancers which develop from them. Cloning the gene showed that the extracellular domain is made up of highly conserved repeats of 20 amino acids, the actual number varying between 25 and 100 depending on the allele.
Taylor-Papadimitriou, J +3 more
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Türk Patoloji Dergisi, 2023 Objective: Lung adenocarcinomas are divided into acinar, lepidic, papillary, micropapillary, and solid predominant subtypes according to the current World Health Organization (WHO) classification.
Melek BUYUK +5 more
doaj +1 more source
The research status and prospects of MUC1 in immunology
Human Vaccines & Immunotherapeutics, 2023 In immune processes, molecular – molecular interactions are complex. As MUC1 often appears to be an important molecule in inflammation and tumor immunity, it is necessary to summarize the leading countries, authors, journals, and the cooperation among ...
Linna Long +7 more
doaj +1 more source
MUC1 in hematological malignancies [PDF]
Leukemia & Lymphoma, 2016 Mucin1 (MUC1) is a transmembrane oncogenic protein that plays a central role in malignant transformation and disease evolution, including cell proliferation, survival, self-renewal, and metastatic invasion. MUC1 has been shown to interact with diverse effectors such as β-catenin, receptor tyrosine kinases, and c-Abl, which are of importance in the ...
Dina, Stroopinsky +2 more
openaire +2 more sources