Results 91 to 100 of about 39,306 (244)

Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins [PDF]

, 2019
Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the
Adamczyk, Barbara, Chahal, Gurdeep, Ducatelle, Richard, Erhardsson, Mattias, Flahou, Bram, Haesebrouck, Freddy, Jin, Chunsheng, Karlsson, Niclas G, Linden, Sara K, Padra, Medea, Smet, Annemieke, Thorell, Anders   +11 more
core   +1 more source

The cytoplasmic domain of MUC1 induces hyperplasia in the mammary gland and correlates with nuclear accumulation of β-catenin. [PDF]

PLoS ONE, 2011
MUC1 is an oncoprotein that is overexpressed in up to 90% of breast carcinomas. A previous in vitro study by our group demonstrated that the cytoplasmic domain of MUC1 (MUC1-CD), the minimal functional unit of MUC1, contributes to the malignant phenotype
Yuan Li, Haiying Yi, Yixin Yao, Xiaodong Liao, Yiqun Xie, Jie Yang, Zheng Yan, Long Wang, Shunyuan Lu, Ying Kuang, Mingmin Gu, Jian Fei, Zhugang Wang, Lei Huang   +13 more
doaj   +1 more source

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, EarlyView.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells [PDF]

, 2017
Epidermal growth factor receptor (EGFR) is an important regulator of epithelial cell growth and survival in normal and cancerous tissues and is a principal therapeutic target for cancer treatment.
A Kharbanda, AC Midgley, Anisha R Chacko, AU Newlaczyl, BG Bitler, BJ Engel, BJ Engel, BT Blakely, D Neeraja, DE Swinson, DW Kufe, EE Er, F Guddo, F Montemurro, FT Liu, H Barrow, HY Kuo, I Iurisci, IC Gaemers, J Hilkens, J Mendelsohn, J Merlin, J Rubin Grandis, J Taylor-Papadimitriou, J Wesseling, JA Schroeder, JC Byrd, John Hilkens, Jonathan M Rhodes, JP Dawson, JY Fang, K Kato, KL Pierce, L Haddon, LG Yu, LG Yu, Lu-Gang Yu, M Alam, MR Pochampalli, N Normanno, NE Hynes, NJ Bessman, Paulina Sindrewicz, PK Singh, Q Zhao, Q Zhao, R Ahmad, RE Beatson, S Bafna, S Ramasamy, S Song, Tushar Piyush, X Wei, Y Mori, Y Umekita   +54 more
core   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Lysine acetyltransferase 5 in EGFR mutated non-small cell lung cancer [PDF]

, 2018
Histone modifications are crucial in activities such as transcriptional activation, gene silencing, and epigenetic cellular memory. In particular, lysine acetylation via lysine (K) acetyltransferases (KATs) has been implicated in cancer development ...
Pan, Gilbert
core  

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination

Cancer Management and Research, 2020
Heng Zhang,1 Hui Zhao,2 Xiaolei He,3 Feng Xi,4 Jiwen Liu1 1School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Department of Radiation Therapy, Xinjiang Uygur Autonomous ...
Zhang H, Zhao H, He X, Xi F, Liu J
doaj  

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, EarlyView.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

Differential expression of MUC genes in endometrial and cervical tissues and tumors [PDF]

, 2005
Background Mucin glycoprotein's are major components of mucus and are considered an important class of tumor associated antigens. The objective of this study was to investigate the expression of human MUC genes (MUC1, MUC2, MUC5B, MUC5AC and MUC8) in ...
Vidya Hebbar, Gautam Damera, Goverdhan P Sachdev, MC Rose, JRJ Gum, GJ Strous, M Hareuveni, V Shankar, SB Ho, CA Reis, CA Reis, CA Reis, M Perrais, T Lesuffleur, N Aksoy, SJ Williams, S Zrihan-Licht, JS Chu, EC Mommers, P Guillem, S Yonezawa, Y Masaki, B Terris, A Ohgami, PM Sharma, CJ Yu, CD Hough, H Feng, IK Gipson, JP Audie, OJ D'Cruz, OJ D'Cruz, SJ Gendler, JR Gum, IK Gipson, RA Smith, ME Hoadley, P Dockery, JD Aplin, NA Hey, J Perez-Vilar, A Dohrman, GA Surveyor, JD Aplin, M Ueda, J Taylor-Papadimitriou, JY Wang, KT Jang, PL Nguyen, GT Layton, BW Yin   +50 more
core   +1 more source