Results 91 to 100 of about 21,152 (196)

Tumor‐Resident Mast Cells Facilitated Breast Cancer Progression via Activating Type I Interferon Pathway

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Breast cancer cell‐derived stem cell factor (SCF) activates c‐KIT‐mediated MAPK/ERK signaling in mast cells, inducing IFNB1 production. Mast cell‐derived IFNB1 then engages the IFNAR1‐STAT1 axis in breast cancer cells, activating the Type I interferon pathway to promote tumor stemness and progression.
Siqin Li, Juchuanli Tu, Ruoyi Ding, Xueyan He, Xian Zhang, Mengxue Dong, Fengkai Li, Wen Yi, Yuwei Tao, Wei Ma, Zhijun Dai, Zhenhua Chen, Yuan Wang, Xiongbin Lu, Jian Liu, Suling Liu, Jiahui Xu   +16 more
wiley   +1 more source

Automated Immunofluorometric Assay for MUC1

Tumor Biology, 2001
The aim of the present study was to establish a robust, reliable and fully automated immunofluorometric assay for the breast cancer serum marker MUC1. This would further serve as a prototype assay for evaluation of other MUC1 assays based on new antibody combinations.
L F, Norum, O, Nilsson, K, Nustad
openaire   +2 more sources

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells

Cell Death Discovery
The oncogenic MUC1-C transmembrane protein is a critical effector of the cancer stem cell (CSC) state. Addiction to MUC1-C for self-renewal in the progression of human cancers has emphasized the need for development of anti-MUC1-C agents.
Tatsuaki Daimon, Atrayee Bhattacharya, Keyi Wang, Naoki Haratake, Ayako Nakashoji, Hiroki Ozawa, Yoshihiro Morimoto, Nami Yamashita, Takeo Kosaka, Mototsugu Oya, Donald W. Kufe   +10 more
doaj   +1 more source

Development of New Models of Oral Mucosa to Investigate the Impact of the Structure of Transmembrane Mucin-1 on the Mucosal Pellicle Formation and Its Physicochemical Properties

Biomedicines
The mucosal pellicle (MP) is a biological film protecting the oral mucosa. It is composed of bounded salivary proteins and transmembrane mucin MUC1 expressed by oral epithelial cells.
Clément Nivet, Irma Custovic, Laure Avoscan, Floris J. Bikker, Aline Bonnotte, Eric Bourillot, Loïc Briand, Hélène Brignot, Jean-Marie Heydel, Noémie Herrmann, Mélanie Lelièvre, Eric Lesniewska, Fabrice Neiers, Olivier Piétrement, Mathieu Schwartz, Christine Belloir, Francis Canon   +16 more
doaj   +1 more source

MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease

Respiratory Research, 2018
Background Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed.
Javier Milara, Lucía Díaz-Platas, Sonia Contreras, Pilar Ribera, Inés Roger, Beatriz Ballester, Paula Montero, Ángel Cogolludo, Esteban Morcillo, Julio Cortijo   +9 more
doaj   +1 more source

Context of MUC1 epitope: Immunogenicity

Oncology Reports, 2007
MUC1 is a glycoprotein found at the secretory poles of normal cells but is hypoglycosylated on the entire surface of cell membranes of adenocarcinomas. In order to determine the influence on the immune response of peptide context for epitope presentation, peripheral blood mononuclear cells (PBMC) from patients with adenocarcinomas, were stimulated with
I S, Quinlin, J S, Burnside, K E, Dombrowski, C A, Phillips, N, Dolby, S E, Wright   +5 more
openaire   +3 more sources

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis

Molecular Cancer, 2012
Background Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration.
Bozkaya Giray, Korhan Peyda, Çokaklı Murat, Erdal Esra, Sağol Özgül, Karademir Sedat, Korch Christopher, Atabey Neşe   +7 more
doaj   +1 more source