Results 91 to 100 of about 28,581 (233)

MUC1 downregulation by shRNA.

, 2013
(A) MUC1 detection by immunofluorescence with HMFG-1 antibody in MKN45-C1 and MKN45-C2 and MKN45-SC control; (B) MUC1 protein detection by western-blot with MUC1-Ab5 antibody of total protein extracts from MKN45-C1 and MKN45-C2 and MKN45-SC control; (C ...
Thomas Caffrey (340525), Filipe Santos-Silva (340526), Michael A. Hollingsworth (179339), Paula Paulo (118862), Natália R. Costa (340523)   +4 more
core   +1 more source

Transmembrane MUC1 assists oral microbial colonization in oral mucosa of potentially malignant disorders and oral squamous carcinoma

European Journal of Oral Sciences, EarlyView.
Abstract Transmembrane mucin 1 (tMUC1) provides oral mucosal barrier against pathogens. The invasion of oncopathogenic microbes can promote cancerous proliferation of cells via inflammatory responses, abnormal cellular signaling, angiogenesis, anti‐adhesion, and tumorigenesis.
Lauriina Soiniemi, Matias Kanniainen, Saga Ramsay, Arja Kullaa, Bina Kashyap   +4 more
wiley   +1 more source

MUC1 in cancer

Holistic Integrative Oncology
Abstract Mucin 1 (MUC1), a prototypical transmembrane mucin, is aberrantly overexpressed and hypoglycosylated in a broad spectrum of epithelial malignancies and hematologic cancers, with its expression level closely correlated with tumor proliferation, metastatic invasion, therapeutic resistance, and poor patient prognosis.
Ke Qian, Yiting Zhang, Qingyu Zhou, Jianming Zhou, Xiang Wu, Jiajun Zhu, Yinchen Pan, Zuyao Wu, Shaomin Li, Yong Lin, Feizhou Lyu, Shuying Chen, Huichuan Sun   +12 more
openaire   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia

, 2022
The mucin 1 (MUC1) gene was discovered based on its overexpression in human breast cancers. Subsequent work demonstrated that MUC1 is aberrantly expressed in cancers originating from other diverse organs, including skin and immune cells.
Kufe, Donald W., Donald W. Kufe
core   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Nucleotide and amino acid sequence of MUC1-TM and MUC1-ARF.

, 2016
MUC1-TM initiation codon is shown in black font and green highlight. Downstream to this initiation codon, three potential MUC1-ARF initiation codons in a +1 frame are shown in red font and green highlight.
John Hilkens (412442), Michael Chalick (3234639), Franz-Georg Hanisch (318572), Armand Bensussan (214677), Oded Jacobi (3234645), Nechama I. Smorodinsky (140867), Tania Zehavi (367263), Ravit Ziv (3234648), Christian Garbar (3234657), Alan Meeker (3234642), Daniel H. Wreschner (3234654), Edward Pichinuk (3234651), Daniel B. Rubinstein (3234636)   +12 more
core   +1 more source

Overexpression and altered glycosylation of MUC1 in malignant mesothelioma [PDF]

, 2008
Current interest in the MUC1/EMA mucin relates to its role in malignancy, and its potential as a therapeutic target. MUC1/EMA expression has been observed in the majority of epithelioid mesotheliomas.
Nowak, A., E Baker, Creaney, J., M J Millward, Sterrett, G., G Sterrett, Millward, M., A Segal, B W S Robinson, Robinson, B., A R Murch, Baker, E., Murch, A., Segal, A., M A Platten, J Creaney, Platten, M., A K Nowak   +17 more
core   +1 more source

MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease

Respiratory Research, 2018
Background Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed.
Javier Milara, Lucía Díaz-Platas, Sonia Contreras, Pilar Ribera, Inés Roger, Beatriz Ballester, Paula Montero, Ángel Cogolludo, Esteban Morcillo, Julio Cortijo   +9 more
doaj   +1 more source

Early Gastric Cancer Detected During 15‐year Surveillance After Ménétrier Disease Remission and Successfully Treated With Endoscopic Submucosal Dissection: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Ménétrier disease (MD) was diagnosed based on hypoalbuminemia and giant gastric folds extending from the body to the fundus in a woman in her 70s. A serum anti‐Helicobacter pylori antibody test and urea breath test yielded negative results.
Takaaki Shamoto, Hideko Yamamoto, Takehito Naito, Masahiro Yamada, Hirotaka Suzuki, Emiko Hida, Takafumi Yamamoto, Yoshifumi Arai, Hiroshi Matsubara   +8 more
wiley   +1 more source