Results 111 to 120 of about 39,306 (244)

Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835] [PDF]

, 2006
INTRODUCTION: Mucin 1 (MUC1) is a high molecular weight glycoprotein overexpressed on adenocarcinoma cells and is a target for immunotherapy protocols. To date, clinical trials against MUC1 have included advanced cancer patients.
Vasso Apostolopoulos, Geoffrey A Pietersz, Anastasios Tsibanis, Annivas Tsikkinis, Heleni Drakaki, Bruce E Loveland, Sara J Piddlesden, Magdalena Plebanski, Dodie S Pouniotis, Michael N Alexis, Ian F McKenzie, Stamatis Vassilaros, GA Pietersz, S Gendler, PX Xing, PX Xing, DL Barnd, CG Ioannides, KR Jerome, B Agrawal, V Apostolopoulos, N Domenech, Y Kotera, A Rughetti, S von Mensdorff-Pouilly, MM Gourevitch, B Acres, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, CJ Lees, CJ Lees, CJ Lees, SA Lofthouse, IF McKenzie, GA Pietersz, GA Pietersz, V Karanikas, V Karanikas, V Karanikas, PX Xing, V Apostolopoulos, BE Loveland, R Gruber, ID Davis, C Rentzsch, Y Hirasawa, S von Mensdorff-Pouilly   +57 more
core   +1 more source

Pancreatic Adenocarcinoma: Diagnosis by Ultrasound‐Guided Fine‐Needle Aspiration—Cyto‐Histological Correlation and Experience at a Multidisciplinary Tertiary Reference Center

Diagnostic Cytopathology, Volume 54, Issue 6, Page 403-416, June 2026.
ABSTRACT Background Pancreatic adenocarcinoma (PDAC) is characterized by its poor prognosis. Cytology is essential for diagnostic confirmation and ancillary studies. The endoscopic ultrasound (EUS) set a precedent, facilitating cytological sampling through fine‐needle aspiration (FNA), with a sensitivity of 93% and a specificity of 95%.
Judith González‐López, Mónica Elizabeth Bauza, Judith Pérez‐Rojas, Cecilia López‐Valdivia, Carlos Zac Romero, Óscar Castells‐Perona, Cristina Ballester‐Ibáñez, Eva Montalvá‐Orón, Rafael López‐Andújar, Lidia Argüello‐Viudez, Mireya Prieto Rodríguez   +10 more
wiley   +1 more source

Context of MUC1 epitope: Immunogenicity

Oncology Reports, 2007
MUC1 is a glycoprotein found at the secretory poles of normal cells but is hypoglycosylated on the entire surface of cell membranes of adenocarcinomas. In order to determine the influence on the immune response of peptide context for epitope presentation, peripheral blood mononuclear cells (PBMC) from patients with adenocarcinomas, were stimulated with
I S, Quinlin, J S, Burnside, K E, Dombrowski, C A, Phillips, N, Dolby, S E, Wright   +5 more
openaire   +3 more sources

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep [PDF]

, 2017
An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising.
Fouladi-Nashta, A A, Ghafari, F, Marei, W F A, Mohey-Elsaeed, O, Raheem, K A, Wathes, D C   +5 more
core   +3 more sources

Development of New Models of Oral Mucosa to Investigate the Impact of the Structure of Transmembrane Mucin-1 on the Mucosal Pellicle Formation and Its Physicochemical Properties

Biomedicines
The mucosal pellicle (MP) is a biological film protecting the oral mucosa. It is composed of bounded salivary proteins and transmembrane mucin MUC1 expressed by oral epithelial cells.
Clément Nivet, Irma Custovic, Laure Avoscan, Floris J. Bikker, Aline Bonnotte, Eric Bourillot, Loïc Briand, Hélène Brignot, Jean-Marie Heydel, Noémie Herrmann, Mélanie Lelièvre, Eric Lesniewska, Fabrice Neiers, Olivier Piétrement, Mathieu Schwartz, Christine Belloir, Francis Canon   +16 more
doaj   +1 more source

Tumor‐Resident Mast Cells Facilitated Breast Cancer Progression via Activating Type I Interferon Pathway

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Breast cancer cell‐derived stem cell factor (SCF) activates c‐KIT‐mediated MAPK/ERK signaling in mast cells, inducing IFNB1 production. Mast cell‐derived IFNB1 then engages the IFNAR1‐STAT1 axis in breast cancer cells, activating the Type I interferon pathway to promote tumor stemness and progression.
Siqin Li, Juchuanli Tu, Ruoyi Ding, Xueyan He, Xian Zhang, Mengxue Dong, Fengkai Li, Wen Yi, Yuwei Tao, Wei Ma, Zhijun Dai, Zhenhua Chen, Yuan Wang, Xiongbin Lu, Jian Liu, Suling Liu, Jiahui Xu   +16 more
wiley   +1 more source

The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation [PDF]

, 2012
MUC1 is a large, heavily glycosylated transmembrane glycoprotein that is proposed to create a protective microenvironment in many adenocarcinomas. Here we compare MUC1 and the well studied cell surface receptor target, EGFR, as gold nanoparticle (AuNP ...
Carson, Daniel D., Constantinou, Pamela E., Danysh, Brian P., Lapotko, Dmitri O., Lukianova-Hleb, Ekaterina Y.   +4 more
core   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells

Cell Death Discovery
The oncogenic MUC1-C transmembrane protein is a critical effector of the cancer stem cell (CSC) state. Addiction to MUC1-C for self-renewal in the progression of human cancers has emphasized the need for development of anti-MUC1-C agents.
Tatsuaki Daimon, Atrayee Bhattacharya, Keyi Wang, Naoki Haratake, Ayako Nakashoji, Hiroki Ozawa, Yoshihiro Morimoto, Nami Yamashita, Takeo Kosaka, Mototsugu Oya, Donald W. Kufe   +10 more
doaj   +1 more source