Results 121 to 130 of about 28,581 (233)

Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing

Life Science Alliance
A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.
Weiwei Peng, Koen CAP Giesbers, Marta Šiborová, J Wouter Beugelink, Matti F Pronker, Douwe Schulte, John Hilkens, Bert JC Janssen, Karin Strijbis, Joost Snijder   +9 more
doaj   +1 more source

MUC1 siRNA-mediates down regulation of MUC1 expression in subcloned cell lines with different intrinsic Δψm.

, 2013
Subcloned cell lines with intrinsic Δψm higher (↑Δψm), lower (↓Δψm) and comparable (≈Δψm) to that of the population, and the SW620 parental population, were mock transfected, or transfected with NT- or MUC1-siRNA.
Barbara G. Heerdt (343407), Leonard H. Augenlicht (242686), Michele A. Houston (343406)   +2 more
core   +1 more source

Australian Standards of Care for Genetic and Genomic Testing in Kidney Disease, Chapter 5

Internal Medicine Journal, Volume 56, Issue S5, Page 18-20, November 2026.
Sadia Jahan, Julia Jefferis, Jacqueline Soraru, Chirag Patel, Erik Biros, Trudie Harris, Kushani Jayasinghe, Amali Mallawaarachchi, Zornitza Stark, Andrew J. Mallett, on behalf of the KidGen Guidelines Working Group   +10 more
wiley   +1 more source

A minimal fragment of MUC1 mediates growth of cancer cells.

, 2008
The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells.
Sanjeev Mahanta, Shawn P. Fessler, Shawn P Fessler, Mahanta Sanjeev, Jaehong Park, Park Jaehong, Bamdad Cynthia, Cynthia Bamdad, Fessler Shawn P.   +8 more
core   +1 more source

GO-203 blocks MUC1-CD homodimerization in cells.

, 2015
293T cells were transiently transfected to express an empty vector and (A) rat GFP-MUC1-CD and FLAG-MUC1-CD, (B) dog GFP-MUC1-CD and FLAG-MUC1-CD or (C) human GFP-MUC1-CD and FLAG-MUC1-CD. At 48 h, cells were left untreated (control) or treated with 5 μM
James Lee (212552), Pankaj Sharma (58141), Praveen Agarwal (782494), Surender Kharbanda (782495), C. James McKnight (252685), Deepak Raina (782493), Donald Kufe (153971), Ajit Bharti (237911)   +7 more
core   +1 more source

Significance of MUC1 and MUC2 mucin expression in colorectal cancer

, 1996
Aims - To compare the lineage specific distribution of MUC1 and MUC2 mucins in normal colorectal mucosa and adenocarcinoma and to identify pathological correlations.
Ajioka, Y., Allison, L. J., Jass, J. R.
core   +1 more source

Customized <i>MUC1</i> Sequencing Enables Diagnosis of Autosomal Dominant Tubulointerstitial Kidney Disease and Unexplained CKD. [PDF]

Kidney Int Rep
García-Aznar JM, Besada-Cerecedo ML, Aguirre NL, Álvarez JP, Boluda-Navarro M, Alvaredo SG, Lesende I, Castañeda-Infante L, León-Machado L, Rodríguez AS, Pérez-Gómez V, Garces EG, Ortiz A, Fresnedo GF, Vilarino MC, Criach EA, Prado de la Sierra JC, Escaño Marín RM, Velázquez MM, Blasco M, Procaccini FL, de Sequera P.   +21 more
europepmc   +1 more source

ABL209 (NEOK002): Designing an EGFR × MUC1 Bispecific TOP1i ADC with Promising Antitumor Activity and Enhanced Therapeutic Window. [PDF]

Mol Cancer Ther
Lee B, Park HJ, Yoo BM, Kim H, Seo A, Hong Y, Lee YS, Yeom D, Son YG, Eom J, Song D, Sung B, Ahn J, Kim J, You WK, Lee SH, Jung J.   +16 more
europepmc   +1 more source

Targeting FEN1 disrupts EIF4A3-mediated MUC1-C autoregulation: a novel strategy to suppress lung adenocarcinoma progression. [PDF]

Cell Death Dis
Wu M, Wu B, Yan X, Wang Z, Mei C, Huang X, Li G, Pang J, Yu L, Liu J.   +9 more
europepmc   +1 more source

Mucin dysregulation in salivary gland tumorigenesis: Diagnostic, prognostic, and therapeutic insights: A systematic review & meta-analysis. [PDF]

J Oral Biol Craniofac Res
Chatterjee S, Vijayakumar G, Anand R, Priya C, Kumari S.   +4 more
europepmc   +1 more source