Results 101 to 110 of about 21,152 (196)

Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
From modular COF design to biomedical translation, this Review maps how linkage chemistry, topology, pore environment, and particle engineering govern bioperformance, therapeutic and diagnostic function, safety, and clinical readiness. Covalent organic frameworks (COFs) are a versatile class of crystalline porous materials with growing potential in ...
Julia Kolodziejczyk, Marta E. Plonska‐Brzezinska   +1 more
wiley   +1 more source

Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing

Life Science Alliance
A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.
Weiwei Peng, Koen CAP Giesbers, Marta Šiborová, J Wouter Beugelink, Matti F Pronker, Douwe Schulte, John Hilkens, Bert JC Janssen, Karin Strijbis, Joost Snijder   +9 more
doaj   +1 more source

MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer

Biomedicines
Patients with pancreatic neuroendocrine tumors (pNETs) have limited access to effective targeted agents and invariably succumb to progressive disease. MUC1-C is a druggable oncogenic protein linked to driving pan-cancers. There is no known involvement of
Hiroki Ozawa, Naoki Haratake, Ayako Nakashoji, Tatsuaki Daimon, Atrayee Bhattacharya, Keyi Wang, Keisuke Shigeta, Atsushi Fushimi, Kazumasa Fukuda, Yohei Masugi, Ryo Yamaguchi, Minoru Kitago, Hirofumi Kawakubo, Yuko Kitagawa, Donald Kufe   +14 more
doaj   +1 more source

Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection

iScience
Summary: Stenotrophomonas maltophilia (Sm), a multidrug-resistant pathogen often isolated from immunocompromised individuals, presents its flagellin to multimeric tandem repeats within the ectodomain of mucin-1 (MUC1-ED), expressed on airway epithelia ...
Erik P. Lillehoj, Yafan Yu, Avelino C. Verceles, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum   +6 more
doaj   +1 more source

Activation of APOBEC3 cytidine deaminases and endogenous retroviruses is integrated by MUC1-C in NSCLC cells

Cell Death Discovery
The APOBEC3 (A3) genes encoding cytidine deaminases evolved in mammals to restrict retroviral replication. The MUC1 gene appeared in mammals to protect barrier tissues from viral infections.
Naoki Haratake, Shinkichi Takamori, Hideko Isozaki, Keisuke Shigeta, Chie Kikutake, Hiroki Ozawa, Atrayee Bhattacharya, Ayako Nakashoji, Mikita Suyama, Tomoyoshi Takenaka, Tomoharu Yoshizumi, Atsushi Osoegawa, Aaron N. Hata, Donald Kufe   +13 more
doaj   +1 more source

MUC1 Protects Preimplantation Embryos In Vitro via Clearance of ROS by Triggering Mitophagy. [PDF]

Cells
Yang J, Li D, Yang C, Deng H, Lin K, Liao B, Liao X, Liu Y, Lyu Q, Huang L.   +9 more
europepmc   +1 more source

Knockout of Mucin 1 inhibits the proliferation, migration, and invasion of human MDA-MB-231 cells by blocking autophagy flow. [PDF]

Braz J Med Biol Res
Huang Z, Zhao J, Zhang Q, Luo Y, Chen W, Liu Z, Liu X.   +6 more
europepmc   +1 more source

Muc1 drives tendon regeneration by activating an endothelial-to-tenocyte PDGFA signaling axis via extracellular vesicles. [PDF]

Mater Today Bio
Xue Y, Sun J, Ji XH, Wang R, Shi JY, Yang QQ, Zhou YL, Tan J.   +7 more
europepmc   +1 more source

MUC1 Antibody [PDF]

, 2020
openaire   +1 more source

MUC1-targeting small peptide radiopharmaceuticals for breast cancer. [PDF]

EJNMMI Radiopharm Chem
Malek R, Landry M, Cheung P, Beinat C.
europepmc   +1 more source