Results 101 to 110 of about 27,684 (225)

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Immunohistochemical analyses of MUC1-TM and MUC1-ARF expression in breast and pancreatic cancer.

, 2016
(A) Serial sections of breast cancer tissues from three distinct individuals were immunohistochemically stained with anti-MUC1-TM antibodies (anti-MUC1-TM [DMB5F3]), anti-MUC1-ARF antibodies (anti-MUC1-ARF [MPR2G10]) and with hematoxylin/eosin (H and E).
John Hilkens (412442), Michael Chalick (3234639), Franz-Georg Hanisch (318572), Armand Bensussan (214677), Oded Jacobi (3234645), Nechama I. Smorodinsky (140867), Tania Zehavi (367263), Ravit Ziv (3234648), Christian Garbar (3234657), Alan Meeker (3234642), Daniel H. Wreschner (3234654), Edward Pichinuk (3234651), Daniel B. Rubinstein (3234636)   +12 more
core   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Mouse cell lines transfected with human MUC1 DNA express MUC1-ARF.

, 2016
(A, and C) DA3 cells transfected with MUC1 cDNA; (B) DA3 cells transfected with human MUC1 genomic DNA, and (D) non-transfected mouse parental DA3 cells were immunostained with anti MUC1-ARF monoclonal antibody MPR2G10 followed by red-labeled secondary ...
John Hilkens (412442), Michael Chalick (3234639), Franz-Georg Hanisch (318572), Armand Bensussan (214677), Oded Jacobi (3234645), Nechama I. Smorodinsky (140867), Tania Zehavi (367263), Ravit Ziv (3234648), Christian Garbar (3234657), Alan Meeker (3234642), Daniel H. Wreschner (3234654), Edward Pichinuk (3234651), Daniel B. Rubinstein (3234636)   +12 more
core   +1 more source

Early Gastric Cancer Detected During 15‐year Surveillance After Ménétrier Disease Remission and Successfully Treated With Endoscopic Submucosal Dissection: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Ménétrier disease (MD) was diagnosed based on hypoalbuminemia and giant gastric folds extending from the body to the fundus in a woman in her 70s. A serum anti‐Helicobacter pylori antibody test and urea breath test yielded negative results.
Takaaki Shamoto, Hideko Yamamoto, Takehito Naito, Masahiro Yamada, Hirotaka Suzuki, Emiko Hida, Takafumi Yamamoto, Yoshifumi Arai, Hiroshi Matsubara   +8 more
wiley   +1 more source

MUC1-EGFR crosstalk with IL-6 by activating NF-κB and MAPK pathways to regulate the stemness and paclitaxel-resistance of lung adenocarcinoma

The chemotherapy resistance often leads to chemotherapy failure. This study aims to explore the molecular mechanism by which MUC1 regulates paclitaxel resistance in lung adenocarcinoma (LUAD), providing scientific basis for future target selection.
Hongyu Xu (3066969), Xueting Li (399689), Xuan Zhang (56049), Zhihui Li (294496), Zedong Du (17926462), Jiayu Ma (7518203), Xianguo Liu (4768134)   +6 more
core   +1 more source

MUC1 downregulation by shRNA.

, 2013
(A) MUC1 detection by immunofluorescence with HMFG-1 antibody in MKN45-C1 and MKN45-C2 and MKN45-SC control; (B) MUC1 protein detection by western-blot with MUC1-Ab5 antibody of total protein extracts from MKN45-C1 and MKN45-C2 and MKN45-SC control; (C ...
Thomas Caffrey (340525), Filipe Santos-Silva (340526), Michael A. Hollingsworth (179339), Paula Paulo (118862), Natália R. Costa (340523)   +4 more
core   +1 more source

The evolving role of immunotherapy in ovarian cancer

Cancer, Volume 132, Issue 18, 15 September 2026.
Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani, Laura Venegas, Amit M. Oza   +2 more
wiley   +1 more source

Cation‐π Interaction‐Based Biointerface for Low‐Cost PD‐1 Detection Toward NSCLC Immunotherapy Monitoring

Advanced Materials Interfaces, Volume 13, Issue 17, 8 September 2026.
A cation‐π interaction‐based biointerface is engineered on a CNT‐FET for label‐free detection of PD‐1. PD‐1 monoclonal antibodies are orientedly immobilized via cation‐π interactions between PCz‐wrapped semiconducting single‐walled carbon nanotubes and the Fc region of the monoclonal antibody.
Chunmin Jia, Yimin Lei, Hong Xu, Xin Meng, Yuxiang Wei, Peixian Li, Xiaohua Ma, Yue Hao, Xiaohui Jia   +8 more
wiley   +1 more source

Rekombinante Antikörper gegen tumorassoziiertes MUC1 [PDF]

, 2003
In Adenokarzinomen wie dem Mammakarzinom wird das tumorassoziierte Antigen MUC1 überexprimiert, dessen extrazelluläre Domäne zum größten Teil aus einem als VNTR (variable number of tandem repeats)-Region bezeichneten Abschnitt besteht.
Toleikis, Lars
core   +1 more source