Results 21 to 30 of about 20,473 (133)

Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro. [PDF]

PLoS ONE, 2012
Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by the adverse effects of cytotoxic agents. Targeted drug delivery may reduce the non-specific toxicity of chemotherapy by selectively directing anticancer drugs to tumor ...
Yan Hu, Jinhong Duan, Qimin Zhan, Fengdan Wang, Xin Lu, Xian-Da Yang   +5 more
doaj   +1 more source

MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells

Journal for ImmunoTherapy of Cancer, 2023
Background The MUC1-C protein evolved in mammals to protect barrier tissues from loss of homeostasis; however, MUC1-C promotes oncogenesis in association with chronic inflammation. Aberrant expression of MUC1-C in cancers has been linked to depletion and
Satoshi Ishikawa, Donald Kufe, Constantine Mitsiades, Nami Yamashita, Atsushi Fushimi, Atrayee Bhattacharya, Yoshihiro Morimoto, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky   +13 more
doaj   +1 more source

MARPLE: A Proximity-Triggered CRISPR-Cas13 Platform for Ultrasensitive Antibody Detection. [PDF]

Adv Sci (Weinh)
MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Spezzani E, Capelli L, Di Lena D, Chamorro-Garcia A, Ippodrino R, Porchetta A, Bertucci A.   +6 more
europepmc   +2 more sources

MUC1 modulates gastric epithelial immune response to bacteria or inflammatory stimuli

Universa Medicina, 2015
BACKGROUND Cell surface mucin glycoproteins are expressed on the mucosal surface. One of these cell surface mucins is mucin-1 (MUC1), which plays a role as a physical barrier and limits inflammation.
Shofyatul Y. Triyana, Yong H. Sheng, Michael McGuckin   +2 more
doaj   +1 more source

Enhancing T Cell and Antibody Response in Mucin-1 Transgenic Mice through Co-Delivery of Tumor-Associated Mucin-1 Antigen and TLR Agonists in C3-Liposomes

Pharmaceutics, 2023
Mucin-1 (MUC1) is a highly relevant antigen for cancer vaccination due to its overexpression and hypo-glycosylation in a high percentage of carcinomas. To enhance the immune response to MUC1, our group has developed C3-liposomes that encapsulate the MUC1
Ameneh Arabi, Shahab Aria (Soltani), Brandon Maniaci, Kristine Mann, Holly Martinson, Max Kullberg   +5 more
doaj   +1 more source

Mucin 1 promotes salivary gland cancer cell proliferation and metastasis by regulating the epidermal growth factor receptor signaling pathway

Journal of Dental Sciences, 2023
Background/purpose: Salivary gland cancer (SGC) is the common malignant tumor of the head and neck region with poor prognosis. Mucin 1 (MUC1) has been reported to be associated with the development of cancer.
Hao Lu, Wan-Lin Xu, Yi-Fan Wu, Wen-Jun Yang, Sheng-Wen Liu   +4 more
doaj   +1 more source

Functional site analysis of mucin 1 in regulating the malignant characteristics of tumor cells

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To identify the functional motifs of mucin 1 (MUC1) involved in regulating tumor cell proliferation, migration, and stemness maintenance.Methods·Mutational characteristics of the MUC1 gene across different cancers were identified from The ...
GAO Kexing, LIAO Chunhua, LI Shengze, MA Shuangyu, HUANG Lei   +4 more
doaj   +1 more source

Regulation of Mucin 1 and multidrug resistance protein 1 by Neuraminidase 1 alters the cytotoxic effects of doxorubicin in breast cancer cells [PDF]

World Cancer Research Journal
Objective: Elevated expression of Multidrug Resistance Protein 1 (MRP1) has been associated with poor prognosis among breast cancer patients. Chemotherapeutic drugs such as doxorubicin (DOX) are substrates of MRP1 that efflux the drug, conferring drug ...
P. Thulasiraman, K. Kerr, A. Wistner
doaj   +1 more source

MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection

Scientific Reports, 2021
We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo.
Avelino C. Verceles, Pavan Bhat, Zain Nagaria, Destiny Martin, Harsh Patel, Afua Ntem-Mensah, Sang W. Hyun, Andrea Hahn, Jean Jeudy, Alan S. Cross, Erik P. Lillehoj, Simeon E. Goldblum   +11 more
doaj   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source