Results 81 to 90 of about 21,687 (212)
Luciferase reporter assay dependent on MUC5AC promoter sequences.
, 2014 (A) NCI-H292 cells were transiently transfected with the various deletion mutants and treated under normoxic or anoxic conditions for 6 h. Hypoxia selectively increased luciferase activity driven by sequences corresponding to the −1400/+4 and −776/+4 ...
Joo-Heon Yoon (311505) +5 more
core +1 more source
Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs [PDF]
, 2012 MUC5AC, a major gel-forming mucin expressed in the lungs, is secreted at increased rates in response to infectious agents, implying that mucins exert a protective role against inhaled pathogens.
Ehre, C. +8 more
core +1 more source
Microbiology SpectrumTo investigate the predictive value of mucin 5AC (MUC5AC) levels in the sputum of children with Mycoplasma pneumoniae pneumonia (MPP) treated with fiberbronchoscopy.
Xiao-qing Jian, Miao Li, Xiao-yan Wang
doaj +1 more source
Secreted human conjunctival mucus contains MUC5AC glycoforms [PDF]
Glycobiology, 1999 This study addresses the extent of variation in secreted end-product mucins in human conjunctival mucus. The aim was to determine whether the variety of mucin species found was encompassed by the mucin genes which have been cloned to date. Extraction into guanidine hydrochloride and separation of mucin constituents, by a combination of cesium chloride ...
R B, Ellingham +3 more
openaire +2 more sources
Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K/Akt/NF-kB in Asthma
Journal of Asthma and Allergy, 2021 Xu Chen,1,2,* Jing Yang,3,* Hailan Shen,4 Xuemei Zhang,1 Hong Wang,1 Guangying Wu,1 Yuhong Qi,1 Ling Wang,1 Wenchun Xu1 1Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine ...
Chen X +8 more
doaj
Allergy, Asthma & Clinical Immunology, 2020 Background Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression of MUC5AC, the major macro ...
Jian Jiao +8 more
doaj +1 more source
Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer
The FEBS Journal, EarlyView.Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa +2 more
wiley +1 more source
Muc5ac mucin expression during rat skin development [PDF]
, 2019 Some mucin genes have been detected during human embryonic and fetal organ development; however, little is known about mucin expression in epidermal development, neither in humans nor in other species. The present research was developed to explore Muc5ac
Barbeito, Claudio Gustavo +3 more
core
, 2012 Purpose: To evaluate a limbal stem cell deficiency (LSCD) diagnosis method based on the detection of the MUC5AC transcript by reverse transcription- polymerase chain reaction (RT-PCR) in comparison with the standard diagnostic method based on goblet cell
García, Iker +4 more
core +1 more source
Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways
Journal of Periodontal Research, EarlyView.This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru +2 more
wiley +1 more source