Results 261 to 270 of about 133,349 (299)

Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis

Interdisciplinary Medicine, EarlyView.
Illustration depicting the isolation of Dipsaci Radix derived extracellular vesicle‐like particles and their function in alleviating osteoporosis. (A) Extraction and characterization detection process of extracellular vesicle‐like particles derived from Dipsaci Radix roots. (B) Cell experiments in vitro, Dipsaci Radix derived extracellular vesicle‐like
Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao   +12 more
wiley   +1 more source

Effect of Zinc Oxide Nanoparticles From Infant Formula Milk Powder on Colon Cells In Vitro

Journal of Applied Toxicology, EarlyView.
ABSTRACT Zinc is an essential trace element that participates in numerous metabolic processes; however, excessive exposure may interfere with the absorption of other metals, such as copper. In recent years, nanotechnology has experienced rapid growth, and zinc oxide nanoparticles (ZnO NPs) have garnered significant attention due to their versatile ...
Gloria Salinas‐Lucero, Karla Juarez‐Moreno, Rafael Vazquez‐Duhalt   +2 more
wiley   +1 more source

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Aptamer-Gated Ion Channel for Ultrasensitive Mucin 1 Detection

Analytical Chemistry, 2021
Detection of cancer markers is important for early diagnosis and timely treatment of cancer. In this study, we fabricated a tailorable gold nanofilm-anodized aluminum oxide (Au-AAO) ion channel through nanoparticle self-assembly and proposed a highly sensitive and selective Mucin 1 (MUC1) detection method.
Mengying Pan, Jiarong Cai, Si Li, Liguang Xu, Wei Ma, Chuanlai Xu, Hua Kuang   +6 more
openaire   +2 more sources

Role of Mucin‐1 in Carcinomas

The FASEB Journal, 2020
Mucin 1 (MUC1) is a large, heavy O‐glycosylated mucin glycoprotein with a molecular weight of 250 to 500 kDa, depending on the level of glycosylation, and extends 200–500 nm from the cell surface. MUC1 spans the cell membrane at the apical surface of normal simple epithelia and the surfaces of some ...
Tina Link, Olivia Caruso, Abhishek Kona, Allison Lu, Zara Saberi, Tara Shabazaz, Varun Vijay   +6 more
openaire   +1 more source

Probing Aberrantly Glycosylated Mucin 1 in Breast Cancer Extracellular Vesicles

ACS Applied Bio Materials, 2023
Aberrantly glycosylated mucin 1 is a critical prognostic biomarker in breast epithelial cancers. Hypoglycosylated mucin 1 coats the surface of the cancer cells, where O-glycans are predominantly linked via an N-acetylgalactosamine moiety (GalNAc).
Saroj Saroj, Debashish Paul, Akbar Ali, Chrysafis Andreou, Suchetan Pal, Tatini Rakshit   +5 more
openaire   +2 more sources

Mucin-1-related T cell infiltration in colorectal carcinoma

Cancer Immunology, Immunotherapy, 1996
Mucins (MUC) are highly glycosylated molecules widely expressed on epithelia of different origins, including colonic mucosa. Altered glycosylation processes in tumour cells result in the exposure of normally cryptic peptide epitopes, which may then be recognized as tumour-specific antigens.
Mulder, W. M.C., Stukart, M. J., De Windt, E., Wagstaff, J., Scheper, R. J., Bloemena, E.   +5 more
openaire   +4 more sources

Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma

Current Cancer Drug Targets, 2022
Abstract:Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC.
Lekshmi R. Nath, Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, Reshma Ravindran Nair   +4 more
openaire   +2 more sources

Designer Tridentate Mucin 1 Aptamer for Targeted Drug Delivery

Journal of Pharmaceutical Sciences, 2012
A single-stranded DNA aptamer (APT) capable of targeting mucin 1 (MUC1) extracellular protein was modified to increase its drug delivery specificity toward MUC1 overexpressing cancer cell line, MCF7. The active targeting region of APT was truncated and variable repeats (one, two, or three) of this sequence were synthesized. An aptamer formed from three
Tan, L., Gee Neoh, K., Kang, E.-T., Choe, W.-S., Su, X.   +4 more
openaire   +2 more sources

Cancer specific Mucin‐1 glycoforms are expressed on multiple myeloma

British Journal of Haematology, 2006
SummaryPresent therapies cannot cure the large majority of patients with multiple myeloma (MM) and therefore new treatment strategies are imperative. This study analysed the different glycosylation profiles of Mucin‐1 (MUC1) on MM and acute myeloid leukaemia (AML) cells using a series of anti‐MUC1 antibodies.
Cloosen, S., Gratama, J., Leeuwen, E.B.M. van, Senden-Gijsbers, B.L.M.G., Oving, E.B.H., Mensdorff-Pouilly, S., Tarp, Mads Peter Agervig, Clausen, Ulla Marie Mandel, Clausen, H., Germeraad, W.T.V., Bos, G.M.J.   +10 more
openaire   +2 more sources