Results 291 to 300 of about 27,431,650 (340)

Targeted delivery of doxorubicin by magnetic mesoporous silica nanoparticles armed with mucin-1 aptamer

Journal of drug targeting (Print), 2019
Distinctive physicochemical features make mesoporous silica magnetic nanoparticles (SPION@SiO2) as a multifunctional nanosystem (NS) for the targeted delivery of therapeutic agents. In the present study, we engineered the mucin-1 (MUC-1) conjugated SPION@
Paniz Siminzar, Y. Omidi, Asal Golchin, Ayuob Aghanejad, J. Barar   +4 more
semanticscholar   +1 more source

Cancer specific Mucin‐1 glycoforms are expressed on multiple myeloma

British Journal of Haematology, 2006
SummaryPresent therapies cannot cure the large majority of patients with multiple myeloma (MM) and therefore new treatment strategies are imperative. This study analysed the different glycosylation profiles of Mucin‐1 (MUC1) on MM and acute myeloid leukaemia (AML) cells using a series of anti‐MUC1 antibodies.
Cloosen, S., Gratama, J., Leeuwen, E.B.M. van, Senden-Gijsbers, B.L.M.G., Oving, E.B.H., Mensdorff-Pouilly, S., Tarp, Mads Peter Agervig, Clausen, Ulla Marie Mandel, Clausen, H., Germeraad, W.T.V., Bos, G.M.J.   +10 more
openaire   +2 more sources

A sensitive electrochemical aptasensor for Mucin 1 detection based on catalytic hairpin assembly coupled with PtPdNPs peroxidase-like activity.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2019
In this work, an ultrasensitive aptasensor for the detection of Mucin 1 (MUC1) was presented based on the target-induced catalytic hairpin assembly combined with excellent mimic peroxidase performance of PtPd bimetallic nanoparticles (PtPdNPs ...
Ruo-Nan Zhao, Zhe Feng, Ya-nan Zhao, Liping Jia, Rongna Ma, Wei Zhang, Lei Shang, Qingwang Xue, Huaisheng Wang   +8 more
semanticscholar   +1 more source

Liposomal Antitumor Vaccines Targeting Mucin 1 Elicit a Lipid-Dependent Immunodominant Response.

Chemistry - An Asian Journal, 2019
The tumor-associated antigen mucin 1 (MUC1) has been pursued as an attractive target for cancer immunotherapy, but the poor immunogenicity of the endogenous antigen hinders the development of vaccines capable of inducing effective anti-MUC1 ...
Jing-jing Du, S. Zou, Xiang-Zhao Chen, Wen-Bo Xu, Chang-Wei Wang, Lian Zhang, Yuan‐Kai Tang, Shi-Hao Zhou, J. Wang, Xu-Guang Yin, Xiao-Fei Gao, Zheng Liu, Jun-Gu Guo   +12 more
semanticscholar   +1 more source

CTL in mice immunized with human mucin 1 are MHC-restricted

The Journal of Immunology, 1995
Abstract CTLs that recognize tumor Ags have been described in mice and humans, particularly for melanoma. These CTLs are CD8+, which is MHC-restricted. In contrast, in human carcinomas of the breast, pancreas, or ovary, and in multiple myeloma, CD8+ CTLs have been described that lyse targets expressing human MUC1 in a non-MHC ...
V, Apostolopoulos, B E, Loveland, G A, Pietersz, I F, McKenzie   +3 more
openaire   +2 more sources

Homogeneous electrochemical aptasensor for mucin 1 detection based on exonuclease I-assisted target recycling amplification strategy.

Biosensors & bioelectronics, 2018
A sensitive and homogeneous electrochemical aptasensor was fabricated for the detection of mucin 1 (MUC1) by combining a well-designed DNA bulge-loop (L-DNA) structure with high-efficient exonuclease I (Exo I)-assisted target recycling amplification ...
Cuiying Lin, Huixia Zheng, Yaying Huang, Zhuling Chen, Fang Luo, Jian Wang, Longhua Guo, Bin Qiu, Zhenyu Lin, Huanghao Yang   +9 more
semanticscholar   +1 more source

Three kinds of DNA-directed nanoclusters cooperating with graphene oxide for assaying mucin 1, carcinoembryonic antigen and cancer antigen 125

Sensors and Actuators B: Chemical, 2018
Malignant tumors posed severe threat to human health, and various efforts have been contributed towards assaying tumor markers, howbeit, achieving to identify the multiple targets by one single analytical mode is in demand. Hereby, three kinds of aptamer-
Yingyi Wang, Shanshan Wang, Chunsong Lu, Xiaoming Yang   +3 more
semanticscholar   +1 more source

Mucin-1-related T cell infiltration in colorectal carcinoma

Cancer Immunology, Immunotherapy, 1996
Mucins (MUC) are highly glycosylated molecules widely expressed on epithelia of different origins, including colonic mucosa. Altered glycosylation processes in tumour cells result in the exposure of normally cryptic peptide epitopes, which may then be recognized as tumour-specific antigens.
Mulder, W. M.C., Stukart, M. J., De Windt, E., Wagstaff, J., Scheper, R. J., Bloemena, E.   +5 more
openaire   +4 more sources

Designer Tridentate Mucin 1 Aptamer for Targeted Drug Delivery

Journal of Pharmaceutical Sciences, 2012
A single-stranded DNA aptamer (APT) capable of targeting mucin 1 (MUC1) extracellular protein was modified to increase its drug delivery specificity toward MUC1 overexpressing cancer cell line, MCF7. The active targeting region of APT was truncated and variable repeats (one, two, or three) of this sequence were synthesized. An aptamer formed from three
Tan, L., Gee Neoh, K., Kang, E.-T., Choe, W.-S., Su, X.   +4 more
openaire   +2 more sources

Silicon nanodot-based aptasensor for fluorescence turn-on detection of mucin 1 and targeted cancer cell imaging.

Analytica Chimica Acta, 2018
We report herein a new dual-color fluorescent aptasensor for detection of tumor marker mucin 1 (MUC1) and targeted imaging of MCF-7 cancer cells based on the specific interaction between MUC1 and its aptamer S2.2.
Yanan Zhang, Shan Guo, Haiyan Huang, Guobin Mao, Xinghu Ji, Zhike He   +5 more
semanticscholar   +1 more source