Results 21 to 30 of about 125,867 (236)
Kidney International Reports, 2017 Sequencing peptides included in the urinary proteome identifies the parent proteins and may reveal mechanisms underlying the pathophysiology of chronic kidney disease.
Zhen-Yu Zhang +15 more
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Cancer Reports, 2022 Background Breast cancer is a very common cancer that can be severe if not discovered early. The current tools to detect breast cancer need improvement. Cancer has a universal tendency to affect glycosylation.
Joonas Terävä +8 more
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Mucin 1 protects against severeStreptococcus pneumoniaeinfection [PDF]
Virulence, 2017 Streptococcus pneumoniae is a bacterial pathogen that commonly resides in the human nasopharynx, typically without causing any disease. However, in some cases these bacteria migrate from the nasopharynx to other sites of the body such as the lungs and bloodstream causing pneumonia and sepsis, respectively.
Poshmaal Dhar +3 more
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Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. [PDF]
PLoS ONE, 2015 We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted agents. Primary cultures of mucin- and mixed-IHCCA were prepared from surgical specimens (N.
Alice Fraveto +15 more
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Mucin 1 Regulates Cox-2 Gene in Pancreatic Cancer [PDF]
Pancreas, 2015 Eighty percent of pancreatic ductal adenocarcinomas (PDAs) overexpress mucin 1 (MUC1), a transmembrane mucin glycoprotein. MUC1(high) PDA patients also express high levels of cyclooxygenase 2 (COX-2) and show poor prognosis. The cytoplasmic tail of MUC1 (MUC1-CT) partakes in oncogenic signaling, resulting in accelerated cancer progression.
Nath, Sritama +4 more
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Mucin 16, the dimerization copycat of mucin 1?
The FASEB Journal, 2021 Mucin 1 (MUC1), a transmembrane mucin that serves a protective role by inhibiting extracellular pathogens from entering epithelial cells is also implicated in forming cancerous cells through dimer formation. Upon expression and localization in the membrane, MUC1 proteins form cysteine‐dependent homodimers through the juxtamembrane domain CQC motif. The
Robert Murphy, Nicole Butch, Edwin Li
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Cells, 2022 Mucin 1 is a transmembrane glycoprotein which overexpresses cancer-specific epitopes (MUC1-CE) on pancreatic ductal adenocarcinoma (PDAC) cells. As PDAC is a low survival and highly aggressive malignancy, developing radioimmunoconjugates capable of ...
Ashleigh Hull +7 more
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Frontiers in Immunology, 2022 The intestinal epithelium surface is covered by a layer of mucus that harbors a complex and dynamic population of bacteria termed gut microbiota. In particular, some gut bacteria have the ability to degrade the mucin glycan for nutritional sources ...
Mingfang Pan +3 more
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Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model [PDF]
Journal of Biomedical Nanotechnology, 2016 Mucin-1 (MUC1), a transmembrane glycoprotein is aberrantly expressed on ~90% of breast cancer and is an excellent target for nanoparticulate targeted imaging. In this study, the development of a dye-doped NIR emitting mesoporous silica nanoparticles platform conjugated to tumor-specific MUC1 antibody (ab-tMUC1-NIR-MSN) for in vivo optical detection of ...
Didier, Dréau +5 more
openaire +2 more sources
Archives of Medical Science, 2019 Introduction Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients.
Fei Yang +4 more
doaj +1 more source