Results 21 to 30 of about 133,349 (299)

Mucin 1 downregulation decreases the anti-tumor effects of melanoma vaccine. [PDF]

Ann Transl Med, 2022
Immunotherapy-based approaches are important breakthroughs with potential treatment benefits for melanoma patients. Mucin 1 (MUC1) is significantly upregulated in melanoma relative to normal cells. It has been reported that MUC1 influences cancer cell proliferation, apoptosis, invasion, and metastasis.The study aimed to explore the effect of MUC1 ...
Shi F, Xue R, Xu H, Mei F, Bao X, Dou J, Zhao F.   +6 more
europepmc   +3 more sources

Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility [PDF]

International Journal of Molecular Sciences, 2014
Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited.
Saeki, Norihisa, Sakamoto, Hiromi, Yoshida, Teruhiko   +2 more
openaire   +2 more sources

Theragnostic perspectives of Mucin 1 for oral cancer

Oral Oncology Reports
Dharmaraj Senthilkumar, Baskar Venkidasamy   +1 more
doaj   +2 more sources

Mucin Level as a Potential Biomarker for Breast Cancer Diagnosis

MCBS (Molecular and Cellular Biomedical Sciences), 2022
Background: Breast cancer is the second leading cause of cancer death and a health problem worldwide. Secreted mucins are upregulated in ductal adenocarcinoma of the breast, however, the use of mucin as breast cancer biomarker has not been established ...
Tagwa Sayed Abdihalim, Alkhair Abd Almahmoud Idris   +1 more
doaj   +1 more source

Mouse mucin 1 (MUC1) defined by monoclonal antibodies [PDF]

International Journal of Cancer, 1998
Mucins are highly expressed in many different human cancers and numerous murine monoclonal antibodies (MAbs) to human mucins, particularly Mucin 1 (MUC1), have been produced. However, no such antibodies to murine mucin 1 (muc1) have been described and we now describe 6 different antibodies produced to murine muc1 and to human MUC1 cytoplasmic tail ...
P X, Xing, C, Lees, J, Lodding, J, Prenzoska, G, Poulos, M, Sandrin, S, Gendler, I F, McKenzie   +7 more
openaire   +2 more sources

Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity [PDF]

, 2016
Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles during embryonic development including patterning, proliferation and ...
Cano, David A., Flores Martínez, Álvaro, Hebrok, Matthias, Herrero Martín, Griselda, Muñoz Bravo, José Luis, Puri, Sapna, Rojas González, Anabel, Taketo, Makoto Mark   +7 more
core   +8 more sources

Evaluation of a Novel Anti-Mucin 1 (MUC1) Antibody (PankoMab) as a Potential Diagnostic Tool in Human Ductal Breast Cancer; Comparison with Two Established Antibodies [PDF]

, 2009
Aim: PankoMab is a novel antibody that recognizes a tumor-specific epitope of Mucin 1 (MUC1). The aim of this study was the evaluation of PankoMab as a potential diagnostic tool and its comparison with two established antibodies against MUC1 in human ...
Dian, Darius, Friese, Klaus, Janni, Wolfgang, Jeschke, Udo, Karsten, Uwe, Kuhn, Christina, Mayr, Doris, Mylonas, Ioannis   +7 more
core   +1 more source

Novel roles for mucin 1 in the kidney [PDF]

Current Opinion in Nephrology and Hypertension, 2017
Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney.Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes.
Al-bataineh, Mohammad, Sutton, Timothy A., Hughey, Rebecca P.   +2 more
openaire   +2 more sources

Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst

Cells, 2020
Embryo implantation into the uterine wall is a highly modulated, complex process. We previously demonstrated that Annexin A1 (AnxA1), which is a protein secreted by epithelial and inflammatory cells in the uterine microenvironment, controls embryo ...
Cristina B. Hebeda, Silvana Sandri, Cláudia M. Benis, Marina de Paula-Silva, Rodrigo A. Loiola, Chris Reutelingsperger, Mauro Perretti, Sandra H. P. Farsky   +7 more
doaj   +1 more source

Expression of aberrantly glycosylated Mucin‐1 in ovarian cancer [PDF]

Histopathology, 2010
Van Elssen C H M J, Frings P W H, Bot F J, Van de Vijver K K, Huls M B, Meek B, Hupperets P, Germeraad W T V & Bos G M J
(2010) Histopathology57, 597–606
Expression of aberrantly glycosylated Mucin‐1 in ovarian cancerAims:  Mucin 1 (MUC1) is an important tumour‐associated antigen (TAA), both overexpressed and aberrantly glycosylated in ...
Van Elssen, Catharina H. M. J., Frings, Peter W. H., Bot, Freek J., Van de Vijver, Koen K., Huls, Mariska B., Meek, Bob, Hupperets, Pierre, Germeraad, Wilfred T. V., Bos, Gerard M. J.   +8 more
openaire   +3 more sources