Results 31 to 40 of about 125,867 (236)

Cornu aspersum mucin attenuates indomethacins-induced gastric ulcers in mice via alleviating oxidative stress and inflammation

Heliyon, 2023
In the past three decades, a significant progress has been made in the prevention and treatment of gastric ulcers. The incidence of the disease has decreased, but gastric ulcer is still a medical problem.
Maha B. Salem, Mohamed Elzallat, Dina Mostafa Mohammed, Safia Samir, Olfat A. Hammam, Marwa Tamim A. Abdel-Wareth   +5 more
doaj   +1 more source

Mucin 1 deficiency mediates corticosteroid insensitivity in asthma

Allergy, 2018
AbstractBackgroundThe loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin can mediate corticosteroid efficacy in chronic rhinosinusitis, but the role of MUC1 in uncontrolled severe asthma is unknown ...
Javier Milara, Anselm Morell, Alfredo de Diego, Enrique Artigues, Esteban Morcillo, Julio Cortijo   +5 more
openaire   +7 more sources

In Vitro Modelling of Barrier Impairment Associated with Gastro-Oesophageal Reflux Disease (GERD)

Clinical and Experimental Gastroenterology, 2021
Marisa Meloni, Paolo Buratti, Francesco Carriero, Laura Ceriotti VitroScreen, In Vitro Innovation Center, Milan, 20149, ItalyCorrespondence: Laura Ceriotti Via Mosè Bianchi, 103, Milan, 20149, ItalyTel +39 02 89077608Email laura.ceriotti@vitroscreen ...
Meloni M, Buratti P, Carriero F, Ceriotti L   +3 more
doaj  

Mucin-1 and its relation to grade, stage and survival in ovarian carcinoma patients

BMC Cancer, 2012
Background Mucin-1 is known to be over-expressed by various human carcinomas and is shed into the circulation where it can be detected in patient’s serum by specific anti-Mucin-1 antibodies, such as the tumour marker assays CA 15–3 and CA 27.29.
Engelstaedter Verena, Heublein Sabine, Schumacher Anamur Lan, Lenhard Miriam, Engelstaedter Helen, Andergassen Ulrich, Guenthner-Biller Margit, Kuhn Christina, Rack Brigitte, Kupka Markus, Mayr Doris, Jeschke Udo   +11 more
doaj   +1 more source

Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases

Frontiers in Immunology, 2021
The amount of mucin secreted by conjunctival goblet cells is regulated to ensure the optimal level for protection of the ocular surface. Under physiological conditions lipid specialized pro-resolving mediators (SPM) are essential for maintaining tissue ...
Anne V. Lyngstadaas, Anne V. Lyngstadaas, Anne V. Lyngstadaas, Markus V. Olsen, Markus V. Olsen, Markus V. Olsen, Jeffrey A. Bair, Robin R. Hodges, Tor P. Utheim, Tor P. Utheim, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +12 more
doaj   +1 more source

MUC1 aptamer-tethered H40-TEPA-PEG nanoconjugates for targeted siRNA-delivery and gene silencing in breast cancer cells

Frontiers in Bioengineering and Biotechnology
With a prevalence of 12.5% of all new cancer cases annually, breast cancer stands as the most common form of cancer worldwide. The current therapies utilized for breast cancer are constrained and ineffective in addressing the condition.
Rajesh Salve, Rajesh Salve, Niladri Haldar, Niladri Haldar, Aazam Shaikh, Aazam Shaikh, Rajkumar Samanta, Rajkumar Samanta, Devyani Sengar, Devyani Sengar, Surajit Patra, Surajit Patra, Virendra Gajbhiye, Virendra Gajbhiye   +13 more
doaj   +1 more source

Investigation of the Effect of Alkali Modification of Mucin on Some Properties of Metronidazole Bioadhesive Tablets

Journal of Applied Sciences and Environmental Management, 2015
The objective of this study was to investigate the effect of alkali treatment of mucin on the mucoadhesive properties and tablet parameters of metronidazole tablets.
SO Eraga, MI Arhewoh, CO Okogbenin, MA Iwuagwu   +3 more
doaj   +1 more source

The Effect of Acid Modification of Porcine Mucin on Its Drug Release and Skin Permeation Properties in Insulin Transdermal Films

Pharmaceutical and Biomedical Research, 2020
Background: The transdermal delivery of insulin involving the use of polymers has been extensively reported. More recently, the use of mucoadhesive or bioadhesive polymers as an insulin base in its formulation is gaining attention possibly due to the ...
Sylvester O. Eraga, Matthew I. Arhewoh, Magnus A. Iwuagwu   +2 more
doaj   +1 more source

Smoking-associated increase in mucins 1 and 4 in human airways [PDF]

Respiratory Research, 2020
Abstract Rationale Smoking-related chronic obstructive pulmonary disease (COPD) is associated with dysregulated production of mucus. Mucins (MUC) are important both for mucus secretion and epithelial defense. We have examined the distribution of MUC1 and MUC4 in the airway epithelial cells of never-smokers and smokers ...
Merikallio, H. (Heta), Kaarteenaho, R. (Riitta), Lindén, S. (Sara), Padra, M. (Médea), Karimi, R. (Reza), Li, C.-X. (Chuan-Xing), Lappi-Blanco, E. (Elisa), Wheelock, Å. M. (Åsa M.), Sköld, M. C. (Magnus C.)   +8 more
openaire   +5 more sources

A Monoclonal Antibody Against the Oncogenic Mucin 1 Cytoplasmic Domain [PDF]

Hybridoma, 2011
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly overexpressed in diverse human carcinomas and certain hematologic malignancies. The transmembrane MUC1-C subunit confers tumorigenicity and is a target for anti-cancer drug development. In this regard, the MUC1-C cytoplasmic domain interacts with multiple effectors that have been linked to ...
Govind, Panchamoorthy, Hala, Rehan, Akriti, Kharbanda, Rehan, Ahmad, Donald, Kufe   +4 more
openaire   +2 more sources