Results 11 to 20 of about 264,845 (357)

The mucin-degradation strategy of Ruminococcus gnavus:The importance of intramolecular trans-sialidases [PDF]

Gut microbes, 2016
We previously identified and characterized an intramolecular trans-sialidase (IT-sialidase) in the gut symbiont Ruminococcus gnavus ATCC 29149, which is associated to the ability of the strain to grow on mucins. In this work we have obtained and analyzed
Crossman, Lisa C., Crost, Emmanuelle H, Henrissat, Bernard, Juge, Nathalie, Monestier, Marie, Swarbreck, David, Tailford, Louise E   +6 more
core   +3 more sources

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

Nature Communications, 2023
This study offers molecular insight into the sialidase and fucosidase decapping apparatus that initiates growth on mucin and promotes nutrient sharing by the dedicated mucolytic symbiont Akkermansia muciniphila with the mucus-associated microbiota.
Bashar Shuoker, M. J. Pichler, C. Jin, Hiroka Sakanaka, Haiyang Wu, Ana Martínez Gascueña, Jining Liu, T. Nielsen, J. Holgersson, E. Nordberg Karlsson, N. Juge, S. Meier, J. P. Morth, N. Karlsson, M. Abou Hachem   +14 more
semanticscholar   +1 more source

A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression

Nature Microbiology, 2023
Akkermansia muciniphila, a mucophilic member of the gut microbiota, protects its host against metabolic disorders. Because it is genetically intractable, the mechanisms underlying mucin metabolism, gut colonization and its impact on host physiology are ...
L. Davey, P. Malkus, Max M. Villa, L. Dolat, Z. Holmes, J. Letourneau, Eduard Ansaldo, L. David, G. Barton, R. Valdivia   +9 more
semanticscholar   +1 more source

Characterizing the mucin-degrading capacity of the human gut microbiota

Scientific Reports, 2022
Mucin-degrading microbes are known to harbor glycosyl hydrolases (GHs) which cleave specific glycan linkages. Although several microbial species have been identified as mucin degraders, there are likely many other members of the healthy gut community ...
Janiece Glover, Taylor Ticer, M. Engevik
semanticscholar   +1 more source

Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development

Gut microbes, 2021
Mucin-degrading bacteria are densely populated in the intestinal epithelium; however, their interaction with intestinal stem cells (ISCs) and their progeny have not been elucidated.
Seungil Kim, Yun-Chan Shin, Tae-Young Kim, Yeji Kim, Yong-soo Lee, Su-Hyun Lee, Mina Kim, Eunju O, K. S. Kim, M. Kweon   +9 more
semanticscholar   +1 more source

Effects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice.

Ecotoxicology and Environmental Safety, 2021
Microplastics are plastic fragments widely distributed in the environment and accumulate in the organisms. However, the research on microplastics effects in mammals is limited. Polyethylene is the main kind of microplastics in the environment.
Hanqing Sun, Na Chen, Xiaona Yang, Yankai Xia, Di Wu   +4 more
semanticscholar   +1 more source

A single sulfatase is required to access colonic mucin by a gut bacterium

Nature, 2021
Humans have co-evolved with a dense community of microbial symbionts that inhabit the lower intestine. In the colon, secreted mucus creates a barrier that separates these microorganisms from the intestinal epithelium1.
A. Luis, C. Jin, G. Pereira, R. Glowacki, Sadie R. Gugel, Shaleni Singh, D. Byrne, Nicholas A. Pudlo, J. London, A. Baslé, M. Reihill, S. Oscarson, P. Eyers, M. Czjzek, G. Michel, T. Barbeyron, E. Yates, G. Hansson, N. Karlsson, A. Cartmell, E. Martens   +20 more
semanticscholar   +1 more source

Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity

Nature Chemical Biology, 2022
Mucins are large gel-forming polymers inside the mucus barrier that inhibit the yeast-to-hyphal transition of Candida albicans, a key virulence trait of this important human fungal pathogen.
J. Takagi, K. Aoki, Bradley S. Turner, S. Lamont, S. Lehoux, N. Kavanaugh, M. Gulati, Ashley Valle Arevalo, Travis J. Lawrence, Colin Y. Kim, B. Bakshi, M. Ishihara, C. Nobile, R. Cummings, D. Wozniak, M. Tiemeyer, Rachel Hevey, K. Ribbeck   +17 more
semanticscholar   +1 more source

Identification of mucin degraders of the human gut microbiota

Scientific Reports, 2021
Mucins are large glycoproteins consisting of approximately 80% of hetero-oligosaccharides. Gut mucin degraders of healthy subjects were investigated, through a culture dependent and independent approach.
S. Raimondi, Eliana Musmeci, Francesco Candeliere, Alberto Amaretti, M. Rossi   +4 more
semanticscholar   +1 more source

Morphometric analysis and mucin histochemistry of gallbladder surface and glandular epithelium in swine [PDF]

Bulgarian Journal of Veterinary Medicine, 2020
The aim of the study was to perform morphometric analysis and to distinguish histochemically the variety of mucins in surface and glandular gallbladder epithelium in swine at different ages.
I. S. Stefanov
doaj   +1 more source