Results 41 to 50 of about 29,844,027 (286)

Heterogeneity and persistence length in human ocular mucins [PDF]

, 2002
Atomic force microscopy (AFM) has been used to investigate the heterogeneity and flexibility of human ocular mucins and their subunits. We have paid particular attention, in terms of theory and experiment, to the problem of inducing the polymers to ...
Stoll, S., Corfield, A. P., Round, A. N., Corfield, AP, Corfield, A., Miles, M., Gowers, D., Round, A.N., Corfield, A.P., Gowers, DM, Berry, M., Miles, M. J., Miles, M.J., Stoll, S, McMaster, TJ, McMaster, T., Gowers, Darren, McMaster, T. J., Berry, Monica, Berry, MS, McMaster, T.J., Miles, MJ, Round, A., Round, AN   +23 more
core   +1 more source

The role of human breast milk mucus and mucins in HIV-AIDS [PDF]

, 2012
Includes abstract.Includes bibliographical references.Milk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk ...
Mthembu, Yolanda
core   +1 more source

MUC1 alleviates PM2.5-induced airway inflammation by inhibiting the IRAK4/NF-κB/NLRP3 mediated pyroptosis in airway epithelial cells

Frontiers in Immunology
BackgroundsExposure to fine particulate matter (PM2.5) triggers airway inflammation through the activation of the Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling pathway, contributing to the pathogenesis of various acute and chronic ...
You Zhou, You Zhou, Kai Yang, Jian Wang, Ruijuan Guan, Wei Liu, Chaowei Wen, Liang Yuan, Tiange Zhang, Wei Feng, Yuanyuan Li, Jingyi Xu, Wenju Lu   +12 more
doaj   +1 more source

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation [PDF]

, 2015
The authors acknowledge the support of the Biotechnology and Biological Sciences Research Council (BBSRC), this research was partly funded by the BBSRC Institute Strategic Programme for The Gut Health and Food Safety (BB/J004529/1) and by the BB/L008602 ...
Vos, W.M., de, Hardy-Goddard, Jemma, Crost, Emmanuelle H., de Vos, Willem M., Gall, G., Le, Taylor, Garry L., Walshaw, J., Tailford, L.E., Crost, E.H., Taylor, G.L., Juge, N., Owen, C.D., Tailford, Louise E., Owen, C. David, Le Gall, G., Le Gall, Gwenaelle, Hardy-Goddard, J., Juge, Nathalie, Walshaw, John, de Vos, W.M.   +19 more
core   +1 more source

The Effect of Acid Modification of Porcine Mucin on Its Drug Release and Skin Permeation Properties in Insulin Transdermal Films

Pharmaceutical and Biomedical Research, 2020
Background: The transdermal delivery of insulin involving the use of polymers has been extensively reported. More recently, the use of mucoadhesive or bioadhesive polymers as an insulin base in its formulation is gaining attention possibly due to the ...
Sylvester O. Eraga, Matthew I. Arhewoh, Magnus A. Iwuagwu   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Relation of Gallbladder Motility to Viscosity and Composition of Gallbladder Bile in Patients with Cholesterol Gallstones [PDF]

, 2009
Background/Aims: Increased viscosity and supersaturation of cholesterol in gallbladder bile, as well as an impaired motility of the gallbladder, are considered to be important factors in the pathogenesis of cholesterol gallstones.
Straub, Gundula, Juengst, Christoph, Schneider, Berthold, del Pozo, Reginald, Juengst, Dieter, Neubrand, Michael, Spelsberg, Fritz W., Althaus, Rupert, Gruendel, Denis, Huettl, Thomas P.   +9 more
core   +1 more source

Lubiprostone stimulates small intestinal mucin release

BMC Gastroenterology, 2012
Background Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion.
De Lisle Robert C
doaj   +1 more source

Mouse mucin 1 (MUC1) defined by monoclonal antibodies [PDF]

International Journal of Cancer, 1998
Mucins are highly expressed in many different human cancers and numerous murine monoclonal antibodies (MAbs) to human mucins, particularly Mucin 1 (MUC1), have been produced. However, no such antibodies to murine mucin 1 (muc1) have been described and we now describe 6 different antibodies produced to murine muc1 and to human MUC1 cytoplasmic tail ...
P X, Xing, C, Lees, J, Lodding, J, Prenzoska, G, Poulos, M, Sandrin, S, Gendler, I F, McKenzie   +7 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source