Results 31 to 40 of about 131,847 (255)

Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases

Frontiers in Immunology, 2021
The amount of mucin secreted by conjunctival goblet cells is regulated to ensure the optimal level for protection of the ocular surface. Under physiological conditions lipid specialized pro-resolving mediators (SPM) are essential for maintaining tissue ...
Anne V. Lyngstadaas, Anne V. Lyngstadaas, Anne V. Lyngstadaas, Markus V. Olsen, Markus V. Olsen, Markus V. Olsen, Jeffrey A. Bair, Robin R. Hodges, Tor P. Utheim, Tor P. Utheim, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +12 more
doaj   +1 more source

Cornu aspersum mucin attenuates indomethacins-induced gastric ulcers in mice via alleviating oxidative stress and inflammation

Heliyon, 2023
In the past three decades, a significant progress has been made in the prevention and treatment of gastric ulcers. The incidence of the disease has decreased, but gastric ulcer is still a medical problem.
Maha B. Salem, Mohamed Elzallat, Dina Mostafa Mohammed, Safia Samir, Olfat A. Hammam, Marwa Tamim A. Abdel-Wareth   +5 more
doaj   +1 more source

The Diagnostic and Predictive Value of Biomarkers for Pulmonary Fibrosis in Patients with Coronavirus Disease 2019

Journal of Global Infectious Diseases
Introduction: In coronavirus disease 2019 (COVID-19), particularly in older people, dysregulated immune response and aberrant repair can result in varied severity secondary pulmonary fibrosis (PF).
Jiapei Lv, Chen Liping, Wang Huaying
doaj   +1 more source

The Effect of Acid Modification of Porcine Mucin on Its Drug Release and Skin Permeation Properties in Insulin Transdermal Films

Pharmaceutical and Biomedical Research, 2020
Background: The transdermal delivery of insulin involving the use of polymers has been extensively reported. More recently, the use of mucoadhesive or bioadhesive polymers as an insulin base in its formulation is gaining attention possibly due to the ...
Sylvester O. Eraga, Matthew I. Arhewoh, Magnus A. Iwuagwu   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Efficacy of MUC1-targeted CAR-NK cells against human tongue squamous cell carcinoma

Frontiers in Immunology
IntroductionThe clinical efficacy of CAR-NK cells against CD19-expressing blood cancers has been demonstrated, and they have shown potential for treating solid tumors as well.
Xiaolan Lin, Tian Guan, Tian Guan, Yun Li, Yun Li, Yanchun Lin, Yanchun Lin, Guowei Huang, Yan Lin, Pingnan Sun, Congzhu Li, Jiang Gu, Haoyu Zeng, Haoyu Zeng, Haoyu Zeng, Haoyu Zeng, Changchun Ma, Changchun Ma, Changchun Ma, Changchun Ma   +19 more
doaj   +1 more source

Lubiprostone stimulates small intestinal mucin release

BMC Gastroenterology, 2012
Background Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion.
De Lisle Robert C
doaj   +1 more source

Mouse mucin 1 (MUC1) defined by monoclonal antibodies [PDF]

International Journal of Cancer, 1998
Mucins are highly expressed in many different human cancers and numerous murine monoclonal antibodies (MAbs) to human mucins, particularly Mucin 1 (MUC1), have been produced. However, no such antibodies to murine mucin 1 (muc1) have been described and we now describe 6 different antibodies produced to murine muc1 and to human MUC1 cytoplasmic tail ...
P X, Xing, C, Lees, J, Lodding, J, Prenzoska, G, Poulos, M, Sandrin, S, Gendler, I F, McKenzie   +7 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

MUC1 alleviates PM2.5-induced airway inflammation by inhibiting the IRAK4/NF-κB/NLRP3 mediated pyroptosis in airway epithelial cells

Frontiers in Immunology
BackgroundsExposure to fine particulate matter (PM2.5) triggers airway inflammation through the activation of the Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling pathway, contributing to the pathogenesis of various acute and chronic ...
You Zhou, You Zhou, Kai Yang, Jian Wang, Ruijuan Guan, Wei Liu, Chaowei Wen, Liang Yuan, Tiange Zhang, Wei Feng, Yuanyuan Li, Jingyi Xu, Wenju Lu   +12 more
doaj   +1 more source