Results 11 to 20 of about 131,847 (255)
Immunohistochemical Expression of HER2/neu, Ki-67 and MUC1 in Benign and Malignant Gall Bladder Lesions and its Association with Clinicopathological Parameters [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Gall Bladder Carcinoma (GBC) is a diagnostic and a therapeutic challenge. Although it is increasing, chronic cholecystitis remains the most worldwide gall bladder lesions, harbouring many epithelial changes that may end in carcinoma ...
Rania G Roshdy +2 more
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Frontiers in Endocrinology, 2021 Follicular thyroid tissue originates from progenitors derived from a midline endodermal primordium. Current understanding infers that folliculogenesis in the embryonic thyroid designates the latest morphogenetic event taking place after the final ...
Ellen Johansson +8 more
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Mucin 16, the dimerization copycat of mucin 1?
The FASEB Journal, 2021 Mucin 1 (MUC1), a transmembrane mucin that serves a protective role by inhibiting extracellular pathogens from entering epithelial cells is also implicated in forming cancerous cells through dimer formation. Upon expression and localization in the membrane, MUC1 proteins form cysteine‐dependent homodimers through the juxtamembrane domain CQC motif. The
Robert Murphy, Nicole Butch, Edwin Li
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Cells, 2022 Mucin 1 is a transmembrane glycoprotein which overexpresses cancer-specific epitopes (MUC1-CE) on pancreatic ductal adenocarcinoma (PDAC) cells. As PDAC is a low survival and highly aggressive malignancy, developing radioimmunoconjugates capable of ...
Ashleigh Hull +7 more
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Irradiation Alters the Expression of MUC1, CD44 and Hyaluronan in Oral Mucosal Epithelium
Biomedicines, 2022 Purpose: It is well established that cancer cells exploit aberrant synthesis of mucin 1 (MUC1) and hyaluronan (HA) synthesis along with HA’s physiological cell surface receptor CD44.
Bina Kashyap +7 more
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Novel roles for mucin 1 in the kidney [PDF]
Current Opinion in Nephrology and Hypertension, 2017 Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney.Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes.
Al-bataineh, Mohammad +2 more
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Mucin Level as a Potential Biomarker for Breast Cancer Diagnosis
MCBS (Molecular and Cellular Biomedical Sciences), 2022 Background: Breast cancer is the second leading cause of cancer death and a health problem worldwide. Secreted mucins are upregulated in ductal adenocarcinoma of the breast, however, the use of mucin as breast cancer biomarker has not been established ...
Tagwa Sayed Abdihalim +1 more
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89Zr-Labeled AR20.5: A MUC1-Targeting ImmunoPET Probe
Molecules, 2020 High expression levels of the tumor-associated antigen MUC1 have been correlated with tumor aggressiveness, poor response to therapy, and poor survival in several tumor types, including breast, pancreatic, and epithelial ovarian cancer. Herein, we report
Kimberly Fung +5 more
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Archives of Medical Science, 2019 Introduction Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients.
Fei Yang +4 more
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Differential expression of mucin 1 and mucin 2 in colorectal cancer
World Journal of Gastroenterology, 2018 To determine tissue expression (mRNA, protein) of two types of mucins [mucin 1 (MUC1) and mucin 2 (MUC2)] in patients with colorectal cancer (CRC).Expression of membrane-bound mucin (MUC1) and secretory mucin (MUC2) in CRC (mRNA, protein) were analyzed in tissue material including fragments of tumors obtained from CRC patients (n = 34), and fragments ...
Kasprzak, Aldona +6 more
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