Novel roles for mucin 1 in the kidney [PDF]
Current Opinion in Nephrology and Hypertension, 2017 Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney.Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes.
Al-bataineh, Mohammad +2 more
openaire +4 more sources
Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility [PDF]
International Journal of Molecular Sciences, 2014 Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited.
Saeki, Norihisa +2 more
openaire +3 more sources
Mucin-1 and its relation to grade, stage and survival in ovarian carcinoma patients [PDF]
BMC Cancer, 2012 Background Mucin-1 is known to be over-expressed by various human carcinomas and is shed into the circulation where it can be detected in patient’s serum by specific anti-Mucin-1 antibodies, such as the tumour marker assays CA 15–3 and CA 27.29.
Engelstaedter Verena +11 more
doaj +4 more sources
Transmembrane Mucin-1 Facilitates Oral Microbial Colonization in Oral Cancer
OralMucins are a family of heavily glycosylated proteins that form the main organic component of the oral mucosal barrier complex. Transmembrane mucin 1 (tMUC1) is anchored at the superficial epithelial surface to provide a protective function.
Bina Kashyap, Arja M. Kullaa
doaj +2 more sources
PB2485: INVESTIGATING THE EXPRESSION OF MUCIN-1 (MUC-1) DURING ERYTHROID DIFFERENTIATION [PDF]
HemaSphere, 2023 Hammad Hassan +4 more
doaj +2 more sources
Immunohistochemical Expression of HER2/neu, Ki-67 and MUC1 in Benign and Malignant Gall Bladder Lesions and its Association with Clinicopathological Parameters [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Gall Bladder Carcinoma (GBC) is a diagnostic and a therapeutic challenge. Although it is increasing, chronic cholecystitis remains the most worldwide gall bladder lesions, harbouring many epithelial changes that may end in carcinoma ...
Rania G Roshdy +2 more
doaj +1 more source
Identification and characterisation of mucin abnormalities in the ganglionic bowel in Hirschsprung's disease [PDF]
, 2010 MDHirschsprung’s disease (HD) is a congenital abnormality of unknown origin, characterised by a lack of ganglion cells in the distal colon which results in functional colonic obstruction.
Speare, Ruth Marian
core +4 more sources
Cells, 2022 Mucin 1 is a transmembrane glycoprotein which overexpresses cancer-specific epitopes (MUC1-CE) on pancreatic ductal adenocarcinoma (PDAC) cells. As PDAC is a low survival and highly aggressive malignancy, developing radioimmunoconjugates capable of ...
Ashleigh Hull +7 more
doaj +1 more source
Mucin 16, the dimerization copycat of mucin 1?
The FASEB Journal, 2021 Mucin 1 (MUC1), a transmembrane mucin that serves a protective role by inhibiting extracellular pathogens from entering epithelial cells is also implicated in forming cancerous cells through dimer formation. Upon expression and localization in the membrane, MUC1 proteins form cysteine‐dependent homodimers through the juxtamembrane domain CQC motif. The
Robert Murphy, Nicole Butch, Edwin Li
openaire +1 more source
Irradiation Alters the Expression of MUC1, CD44 and Hyaluronan in Oral Mucosal Epithelium
Biomedicines, 2022 Purpose: It is well established that cancer cells exploit aberrant synthesis of mucin 1 (MUC1) and hyaluronan (HA) synthesis along with HA’s physiological cell surface receptor CD44.
Bina Kashyap +7 more
doaj +1 more source