Results 141 to 150 of about 56,983 (285)

3D virtual histology demonstrates tumour connectivity in spread through air spaces (STAS) of non‐small cell lung cancer

Histopathology, EarlyView.
STAS‐positive lung nodules were analysed using histology, clinical CT, and synchrotron‐based μCT. μCT enables 3D spatial insights of STAS clusters which appear consistently connected to alveolar or vascular structures, suggesting non‐random distribution.
Giulia Saccomano, Francesco Brun, Fulvia Martellani, Cristina Bottin, Stefano Lovadina, Marina Troian, Maria Assunta Cova, Elisa Baratella   +7 more
wiley   +1 more source

High prevalence of loss of Claudin‐18 expression in invasive non‐mucinous lung adenocarcinoma: Potential diagnostic implications in routine practice

Histopathology, EarlyView.
Loss of Claudin‐18 (Cldn18) expression is a frequent and specific feature of non‐mucinous lung adenocarcinoma (NM‐LUAD). Cldn18 immunohistochemistry may serve as an ancillary tool for distinguishing malignant from non‐neoplastic alveolar epithelium, as well as for differentiating NM‐LUADs with mucin production from M‐LUADs, particularly in small or ...
Stefano Lucà, Marco Montella, Mario Fordellone, Riccardo Monti, Maria Giulia Disanto, Giuseppa Zannini, Marina Accardo, Maria Ali, Gaetano Di Guida, Carminia Maria Della Corte, Beatrice Leonardi, Severo Campione, Valerio Nardone, Floriana Morgillo, Alfonso Fiorelli, Luisella Righi, Mattia Barbareschi, Luka Brcic, Renato Franco   +18 more
wiley   +1 more source

Endocervical gastric‐type AIS: a rare histologic finding that further supports the hypothesis of a pyloric‐type metaplastic origin

Histopathology, EarlyView.
Background Gastric‐type adenocarcinoma in situ (gAIS) is a rare, HPV‐independent precursor of cervical adenocarcinoma with incompletely defined histogenesis. Aims To report a case of gAIS and its association with pyloric‐type gastric metaplasia. Materials and Methods A case of gAIS in a 70‐year‐old woman with atypical glandular cells (Pap test) and ...
Michele Paudice, Veronica Parrella, Giulia Scaglione   +2 more
wiley   +1 more source

Gain‐of‐function enhancers optimize CAR‐NK cell‐based anti‐cancer immunotherapy

Immunology &Cell Biology, EarlyView.
Schematic overview of the two‐stage screening approach used to identify NK cell fitness genes. (A) CRISPRa mechanism, showing dCas9‐VP64‐mediated upregulation of target genes. (B) Whole‐genome CRISPRa screening in HER2‐CAR‐NK92 cells transduced with a CRISPR sgRNA library and transferred into mice bearing HT29 tumours, followed by tumour collection and
Emma Wong, Fernando Souza‐Fonseca‐Guimaraes   +1 more
wiley   +1 more source

GERD and Upper Aerodigestive Tract Cancer Risk: A Systematic Review and Meta‐Analysis

The Laryngoscope, Volume 136, Issue 5, Page 2008-2017, May 2026.
ABSTRACT Objective Gastroesophageal reflux disease (GERD) is highly prevalent, yet its association with upper aerodigestive tract (UADT) cancers beyond esophageal adenocarcinoma remains incompletely defined. This systematic review and meta‐analysis aimed to quantify the risk of specific UADT cancers in individuals with GERD.
Janice Huang, Nicolas Jo, Garret Forman, Tonya Aaron, Sophia Peifer, Soumil Prasad, Luke van Leeuwen, Laura Wild, Nicholas DiStefano, Zhibin Chen, Elizabeth Franzmann   +10 more
wiley   +1 more source

Mucinous adenocarcinoma in kidneys with developmental anomalies - a report of two cases

BMC Urology
Background Primary mucinous adenocarcinomas of the kidney are rare and pose a challenge for preoperative diagnosis. The histogenesis of these tumours remains largely unknown, with three proposed theories: chronic irritation, differentiation of celomic ...
Kasi Viswanath Gali, Arun Chawla, K. R. Surag, Sunil Pillai Bhaskara, Padmaraj Hegde   +4 more
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Deep learning‐based H&E‐derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response

The Journal of Pathology, Volume 269, Issue 1, Page 112-124, May 2026.
Abstract Over recent years, several deep learning (DL) models have been presented to predict colorectal cancer (CRC) patient survival directly from haematoxylin and eosin (H&E)‐stained routine whole‐slide images (WSIs). Unlike traditional studies that rely on manually defined histopathological features, weakly supervised DL allows training directly on ...
Nic G Reitsam, Xiaofeng Jiang, Junhao Liang, Bianca Grosser, Veselin Grozdanov, Chiara ML Loeffler, Marco Gustav, Tim Lenz, Hannah S Muti, Zunamys I Carrero, Nicholas P West, Philip Quirke, Sebastian Foersch, Moritz Jesinghaus, Wolfram Müller, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Jitendra Jonnagaddala, Nicholas J Hawkins, Robyn L Ward, Heike I Grabsch, Bruno Märkl, Jakob N Kather   +23 more
wiley   +1 more source

Optimized workup of lymph nodes in regard to UICC classification of colorectal carcinoma

Histopathology, Volume 88, Issue 6, Page 1250-1267, May 2026.
Treatment and outcome of colon cancer depend significantly on the histopathological examination of lymph nodes. Methodologically, stepwise sectioning and immunohistochemistry are the primary methods used. The extent of this examination is subject to debate but should be maintained at an adequate level in routine laboratory work.
Moritz Rust, Nabih Farkouh, Piet Beusker, Ali Eissing‐Al‐Mukahal, Clara Böker, Julian Mall, Ludwig Wilkens   +6 more
wiley   +1 more source

Making sense of TILs: recommendations for morphological assessment of tumour‐infiltrating lymphocytes in gastro‐oesophageal carcinoma

Histopathology, Volume 88, Issue 6, Page 1126-1141, May 2026.
This review examines the role of tumour‐infiltrating lymphocytes (TILs) in gastro‐oesophageal carcinoma (GEC), focusing on their composition, clinical relevance and therapeutic utility. It proposes a framework for standardised evaluation and reporting of TILs, addressing GEC‐specific pathology challenges to support the widespread use and validation of ...
Ylva A Weeda, Roberto Salgado, Filip van Herpe, Daniel Sur, Michael Vieth, Sherene Loi, Ahmad P Tafti, Hardas Alexandros, Akira I Hida, Amarpreet Bhalla, Andrey I Khramtsov, Anna Ehinger, Atsushi Tanaka, Balazs Acs, Caner Ercan, Cornelia M Focke, Daniel Ehinger, Dan Huang, Galina F Khramtsova, Haruto Nishida, Nianyi Li, Nickolas Littlefield, Sanna Steen, Selim Sevim, Shin Ichihara, Shinnosuke Morikawa, Stefan Michiels, Thomas Papathomas, Toshihiro Haga, Qiangqiang Gu, Weiqi Sheng, Hoel Kervadec, Hugo M Horlings, Francisco Sanchez‐Vega, Yelena Y Janjigian, Myriam Chalabi, Hanneke W M van Laarhoven, Liudmila L Kodach, Sybren L Meijer   +38 more
wiley   +1 more source