Results 151 to 160 of about 434,754 (278)

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, Volume 31, Issue 5, Page 484-497, May 2026.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Airway Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease Patients: From Basic Pathophysiology to Rehabilitation Approaches

Surabaya Physical Medicine and Rehabilitation Journal
Objective: This narrative review aimed to describe the pathophysiology of mucus accumulation and mucus expectoration disorders, rehabilitation assessments, and airway clearance techniques in chronic obstructive pulmonary disease (COPD) patients ...
Arnengsih Nazir, Brandon Clementius
doaj   +1 more source

First Serological Evidence of Avian Metapneumovirus and Infectious Laryngotracheitis Virus in Commercial Poultry in the Ashanti Region of Ghana

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study reports the first serological evidence of avian metapneumovirus and infectious laryngotracheitis virus in commercial poultry in Ghana. High aMPV seroprevalence (49%) and lower ILTV prevalence (7%) were detected, with some coinfection.
Patrick Mensah Amponsah, Kwadwo Boampong, Augustina Angelina Sylverken   +2 more
wiley   +1 more source

Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract

Aging Cell, Volume 25, Issue 5, May 2026.
Telomere shortening occurs with age in the respiratory epithelium, but telomere dysfunction‐induced foci (TIF) accumulate only late in life. In contrast, proteostasis decline emerges earlier and correlates with functional impairment, suggesting it may be a primary driver of cellular senescence during physiological aging.
Céline Coquette, Kamar Bouchoucha, Manon Mahieu, Stijn E. Verleden, Axelle Loriot, Kevin Norris, Duncan M. Baird, Amélie Derumier, Delphine Hoton, Laurens De Sadeleer, Arno Vanstapel, Bart M. Vanaudenaerde, Maëlle de Ville de Goyet, Bénédicte Brichard, Antoine Froidure, Wim Wuyts, Jan Van Slambrouck, Laurens J. Ceulemans, William Trigaux, Caroline Huart, Anabelle Decottignies   +20 more
wiley   +1 more source

Ambulatory Care for Emphysema and Chronic Bronchitis [PDF]

, 1973
The immense problem of chronic airway obstruction (CAO)--emphysema and chronic bronchitis--which has now reached epidemic proportions, presents to the practitioner of medicine an increasing number of suffering persons asking for care.
Petty, Thomas L.
core   +1 more source

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, Volume 81, Issue 5, Page 1459-1471, May 2026.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source

Association Between Perceived COVID‐19 Risk and Current Use of Any Nicotine Product Amongst Adolescents in Saudi Arabia

Drug and Alcohol Review, Volume 45, Issue 4, May 2026.
ABSTRACT Introduction The COVID‐19 pandemic created a unique context for tobacco‐related risk communication amongst adolescents. This study examined the link between COVID‐19–related smoking risk perceptions and current nicotine use amongst Saudi school adolescents.
Najim Z. Alshahrani, Abdullah M. Alarifi, Ibrahim Alasqah, Ahmed K. Shukri, Abdulrahman M. Albeshry, Mohannad A. Alzain, Abdullah Algarni, Mowffaq Mohammed Kalantan, Mohamed Terra, António Raposo, Nada Alqarawi, Sarah Almutairi, Mohamed Baklola   +12 more
wiley   +1 more source

Endoscopically assessed mucus parameters in equine asthma: Relationship to clinical history and cytological findings data

Equine Veterinary Journal, Volume 58, Issue 3, Page 767-778, May 2026.
Abstract Background Mucus parameters are hallmark diagnostic features of equine asthma (EA). Objectives To investigate the relationship between mucus quantity score and mucus viscosity score with signalment, history, clinical findings and cytological parameters. Study Design Retrospective cross‐sectional study.
Julia Drespling, Leonie Berwanger, Heike Kühn, Bianca Schwarz, Marcus Doherr, Lars Mundhenk   +5 more
wiley   +1 more source

Prescription and use of ward‐delivered nasal high‐flow oxygen and non‐invasive ventilation for people with acute respiratory failure

Internal Medicine Journal, Volume 56, Issue 5, Page 908-913, May 2026.
Abstract Nasal high‐flow therapy with oxygen entrained (HFNO) and non‐invasive ventilation (NIV) are important therapies for managing acute respiratory failure (ARF) in the ward‐based setting. The European Respiratory Society released guidelines in 2022 recommending the use of HFNO over conventional oxygen therapy and NIV in patients with hypoxic ARF ...
Aiden Cushnahan, Amelia Harrison, Catherine Buchan, Matthew T. Naughton, Eli Dabscheck, Natasha Smallwood   +5 more
wiley   +1 more source

Preliminary Clinical Outcomes of Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes in Chronic Rhinosinusitis With Nasal Polyps: A Case Report

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a persistent inflammatory disease that may be resistant to medical management and recurs with traditional surgery. We report a 28‐year‐old male with a history of CRSwNP with comorbid asthma, who was resistant to all medical management, including saline irrigation, intranasal corticosteroids (
Manoochehr Avatef‐Fazeli, Gelavizh Rostaminasab, Iman Janghorban Esfahani, Amir Barimani, Kamran Mansouri   +4 more
wiley   +1 more source