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Theophylline and mucociliary clearance
Chest, 1987Abnormal mucociliary transport is improvement by the action of theophylline, and this effect can be attributed to several mechanisms. The drug may directly and indirectly mediate the increase in the secretory output of bronchial glands, and this effect is enhanced by the vagal gastropulmonary reflex which is stimulated by the irritant action of ...
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Mucociliary clearance: pathophysiological aspects
Clinical Physiology and Functional Imaging, 2013SummaryMucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung diseases characterized by defective mucus clearance
Munkholm, Mathias, Mortensen, Jann
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The Effects of Ethanol on Mucociliary Clearance
Alcoholism: Clinical and Experimental Research, 1985Mucociliary clearance by the in vitro frog palate can be used as a model to study such clearance by mammalian lung. Frog palates bathed in Ringer's solution exhibited a constant mucociliary clearance rate for over 2 hr. When the bathing solution was exchanged for one containing ethanol, the mucociliary clearance rate was de‐tectabty inhibited by 300 mg/
G J, Leitch, L H, Frid, D, Phoenix
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Mucociliary Clearance in Adult Asthma
American Review of Respiratory Disease, 1992Abstract Severe impairment of mucociliary clearance (MC) in hospitalized asthmatics has recently been demonstrated in peripheral and central airways. MC was also shown to improve with clinical recovery and hospital discharge (2). In the present study, we measure MC in chronic, stable asthma in subjects with a wide range of obstruction
T G, O'Riordan, J, Zwang, G C, Smaldone
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Mucociliary Clearance in the Trachea
Clinics in Chest Medicine, 1986Tracheal mucociliary clearance is governed by the interplay between ciliary activity and secretory functions of the epithelium. These functions are altered transiently by various physiologic and injurious stimuli, and chronically in asthma, chronic bronchitis, cystic fibrosis, and other forms of airway disease.
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Mammalian Respiratory Mucociliary Clearance
Archives of Environmental Health: An International Journal, 1973An in vivo model was designed to provide information on the major factors affecting mammalian mucociliary clearance. It involves simultaneous quantitation of mucous load, tracheal transport velocity, ciliary beat frequency, and rheological properties of mucus. Values in 23 cats were obtained. The results were remarkably consistent for the group as well
K B, Adler, O, Wooten, M J, Dulfano
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Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity.
Journal of Biomechanics, 2019Intranasal drug delivery has attracted significant attention because of the opportunity to deliver systemic drugs directly to the blood stream. However, the mucociliary clearance poses a challenge in gaining high efficacy of intranasal drug delivery ...
Y. Shang, K. Inthavong, J. Tu
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Bromhexine and mucociliary clearance in chronic bronchitis
British Journal of Diseases of the Chest, 1974Abstract Lung mucociliary clearance was assessed in 9 patients with chronic bronchitis from the rate of removal of previously inhaled particles tagged with a radioisotope (99mTc) before and after the administration of bromhexine (Bisolvon) 16 mg three times daily.
M L, Thomson +3 more
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Effect of Atropine on Nasal Mucociliary Clearance
Acta Oto-Laryngologica, 1990To investigate the effect of atropine on mucociliary function, nasal mucociliary clearance was measured with two methods in eight healthy men before and after subcutaneous injection of atropine sulphate. The movement of two different tracers placed 1.5 cm posterior to the inferior turbinate tip was measured.
K, Takeuchi +3 more
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