Results 51 to 60 of about 18,615 (195)

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Cilia beating misalignment, immotility or death pathologically affect the efficiency of mucus-clearance

Communications Physics
To perform mucociliary clearance, motile cilia covering the surface of the respiratory tract coordinate their beating motions to push mucus out of the upper airways.
Émeline Laborie, Simone Melchionna, Fabio Sterpone   +2 more
doaj   +1 more source

Batuk Kronik pada Anak: masalah dan tata laksana

Sari Pediatri, 2016
Batuk kronik pada anak cukup banyak dijumpai dalam praktek sehari-hari. Pada pasien anak, gejala batuk yang kronik atau berulang dapat mengganggu aktivitas sehari-hari, mengurangi nafsu makan, dan pada akhirnya dapat mengganggu proses tumbuh kembang ...
Darmawan B Setyanto
doaj   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid

Multidisciplinary Respiratory Medicine, 2017
Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air.
Desiderio Passali, Chiara Cappello, Giulio Cesare Passali, Cemal Cingi, Codrut Sarafoleanu, Luisa Maria Bellussi   +5 more
doaj   +1 more source

Establishment of a Human Cell‐Based In Vitro Test System for Investigating and Evaluating Cytotoxic and Immunomodulatory Effects of Indoor Mold

Environmental Toxicology, EarlyView.
ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff, Jessica Reinert, Silke Steinborn, Marion Berger, Judith Neuhoff, Lennart Marske, Kerttu Valtanen, Udo Jäckel, Stefanie Klar   +8 more
wiley   +1 more source

Diagnosis of respiratory epithelial clearance abnormality in patients suffering from chemo-resistant pulmonary tuberculosis with comorbidity of bronchial mucosa

Patologìâ, 2018
Respiratory epithelial clearance timely and early disorder diagnosis in patients suffering from chemo-resistant pulmonary tuberculosis (CRPTB) concomitant pathology of the bronchial mucosa is an actual problem of modern phthisiology, the solution of ...
O. M. Raznatovska, V. M. Khlystun
doaj   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

PLACE OF MUKOACTIVE THERAPY OF RINOSINUSITIS IN INTERNATIONAL AND RUSSIAN GUIDELINES

Медицинский совет, 2017
Excessive accumulation of mucous secretions in the nasal cavity and paranasal sinuses is key drivers in the pathogenesis  of rhinosinusitis. Mucoactive drugs are actively used to combat this phenomenon.
S. V. Ryazantsev, S. A. Altushkin, M. A. Budkovaya   +2 more
doaj   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source