Results 51 to 60 of about 21,273 (241)

The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance

Frontiers in Medicine, 2020
α-klotho (KL) is an anti-aging protein and has been shown to exert anti-inflammatory and anti-oxidative effects in the lung and pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
Jaleesa Garth, Molly Easter, Elex Skylar Harris, Elex Skylar Harris, Juliette Sailland, Lisa Kuenzi, Samuel Chung, Samuel Chung, John S. Dennis, John S. Dennis, Nathalie Baumlin, Nathalie Baumlin, Adegboyega T. Adewale, Steven M. Rowe, Steven M. Rowe, Gwendalyn King, Christian Faul, Jarrod W. Barnes, Jarrod W. Barnes, Matthias Salathe, Matthias Salathe, Stefanie Krick, Stefanie Krick   +22 more
doaj   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Nasal Mucociliary Clearance in Coal Mine Workers

, 2004
OBJECTIVEThe purpose of this study was to analyze the effect of coal dust particles on nasal mucociliary function in coal mine workers.METHODUsing the saccharin method, nasal mucociliary clearance was determined for 77 subjects, of which 39 who worked in
Fikret Çinar, Levent Bekir Beder, Levent Beder   +2 more
core   +1 more source

Effect of needle puncture and electro-acupuncture on mucociliary clearance in anesthetized quails

BMC Complementary and Alternative Medicine, 2006
Background Acupuncture therapy for obstructive respiratory diseases has been effectively used in clinical practice and the acupuncture points or acupoints of Zhongfu and Tiantu are commonly-used acupoints to treat patients with the diseases.
Wang Tianshan, Xutian Stevenson, Sun Feng, Wang Jiulin, Tai Shusheng, King Malcolm   +5 more
doaj   +1 more source

Regulation of mucociliary clearance in health and disease [PDF]

European Respiratory Journal, 1999
Airway secretions are cleared by mucociliary clearance (MCC), in addition to other mechanisms such as cough, peristalsis, two-phase gas-liquid flow and alveolar clearance. MCC comprises the cephalad movement of mucus caused by the cilia lining the conducting airways until it can be swallowed or expectorated.
E, Houtmeyers, R, Gosselink, G, Gayan-Ramirez, M, Decramer   +3 more
openaire   +2 more sources

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Cilia beating misalignment, immotility or death pathologically affect the efficiency of mucus-clearance

Communications Physics
To perform mucociliary clearance, motile cilia covering the surface of the respiratory tract coordinate their beating motions to push mucus out of the upper airways.
Émeline Laborie, Simone Melchionna, Fabio Sterpone   +2 more
doaj   +1 more source

Batuk Kronik pada Anak: masalah dan tata laksana

Sari Pediatri, 2016
Batuk kronik pada anak cukup banyak dijumpai dalam praktek sehari-hari. Pada pasien anak, gejala batuk yang kronik atau berulang dapat mengganggu aktivitas sehari-hari, mengurangi nafsu makan, dan pada akhirnya dapat mengganggu proses tumbuh kembang ...
Darmawan B Setyanto
doaj   +1 more source

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source