Results 111 to 120 of about 134,087 (293)

Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity.

, 2007
BackgroundProbiotics are proposed to positively modulate the intestinal epithelial barrier formed by intestinal epithelial cells (IECs) and intercellular junctions. Disruption of this border alters paracellular permeability and is a key mechanism for the
Jan Buer, Rogler, Gerhard, Hansen, Wiebke, Buer, Jan, Wiebke Hansen, Gunzer, Florian, Seidler, Ursula, Ukena, Sya N, Astrid M. Westendorf, Sebastian Suerbaum, Ulrike Dringenberg, Sya N Ukena, Franzke, Anke, Anke Franzke, Engelhardt, Regina, Bleich, André, Dringenberg, Ulrike, Regina Engelhardt, Suerbaum, Sebastian, André Bleich, Sya N. Ukena, Dunja Bruder, Westendorf, Astrid M, Gerhard Rogler, Anurag Singh, Ursula Seidler, Bruder, Dunja, Florian Gunzer, Astrid M Westendorf, Singh, Anurag   +29 more
core   +1 more source

Targeting the Mucosal Barrier: How Pathogens Modulate the Cellular Polarity Network [PDF]

, 2017
The mucosal barrier is composed of polarized epithelial cells with distinct apical and basolateral surfaces separated by tight junctions and serves as both a physical and immunological barrier to incoming pathogens.
Travis R. Ruch, Ruch, Travis, Joanne N. Engel, Engel, Joanne   +3 more
core   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors

, 2015
Gut barrier is a functional unit organized as a multi-layer system and its multiple functions are crucial for maintaining gut homeostasis. Numerous scientific evidences showed a significant association between gut barrier leaking and gastro-intestinal ...
Lopetuso, Loris Riccardo, Scaldaferri, Franco, Gasbarrini, Antonio, Franceschi, Francesco, Petito, Valentina   +4 more
core  

Transferable Deep Reinforcement Learning With Edge‐Contour‐Depth Fusion for Autonomous Wireless Capsule Endoscopy Navigation

Advanced Science, EarlyView.
This study presents an anatomical landmark‐guided DRL framework for autonomous wireless capsule endoscopy navigation. Using a lightweight edge‐contour‐depth fusion module, it achieves over 97% coverage across diverse gastric anatomies. To ensure reliability, a two‐stage sim‐to‐real pipeline with an adaptive dynamic programming controller mitigates ...
Haoxuan Wu, Haitao Gao, Qingyang Liu, Sishen Yuan, Haiyang Fang, Mingwu Su, Baijia Liang, Yongzun Yang, Long Bai, Wenzhen Dong, Dihong Xie, Shijian Su, Jiewen Lai, Shing Shin Cheng, Zhen Li, Xiuli Zuo, Hongliang Ren   +16 more
wiley   +1 more source

Intestinal damage precedes mucosal immune dysfunction in SIV infection

, 2018
HIV and pathogenic SIV infection are characterized by mucosal dysfunction including epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial translocation with accompanying inflammation.
Hu, Shiu-Lok, Hensley-McBain, Tiffany, Agricola, Brian, Miller, Charlene J, Estes, Jacob D, Klatt, Nichole R, Jennifer A. Manuzak, Mark Cameron, Jacob D. Estes, Jeremy Smedley, R. Keith Reeves, Zevin, Alexander S, Smedley, Jeremy, Gile, Jillian, Reeves, R Keith, Nichole R. Klatt, Alexander S. Zevin, Patricia Polacino, Jillian Gile, Alicia R. Berard, Cameron, Mark, Burgener, Adam D, Manuzak, Jennifer A, Polacino, Patricia, Keele, Brandon F, Brandon F. Keele, Brian Agricola, Berard, Alicia R, Tiffany Hensley-McBain, Adam D. Burgener, Charlene J. Miller, Shiu-Lok Hu   +31 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Gastric and intestinal barrier impairment in tropical enteropathy and HIV: limited impact of micronutrient supplementation during a randomised controlled trial

, 2010
Background Although micronutrient supplementation can reduce morbidity and mortality due to diarrhoea, nutritional influences on intestinal host defence are poorly understood.
Sanderson, IR, Sanderson Ian R, Shawa, T, Tamara Shawa, Shawa Tamara, Barclay G Robin, Stayner Mwanamakondo, G Robin Barclay, Ian R Sanderson, Soko Rose, Mwanamakondo Stayner, Kelly Paul, Mwanamakondo, S, Barclay, GR, Rose Soko, Paul Kelly, Geoff Smith, Smith Geoff, Soko, R, Smith, G, Kelly, P   +20 more
core   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity

Journal of Inflammation Research, 2023
Shuyan Feng,1,* Chi Zhang,1,* Shanshan Chen,2,* Ruonan He,1,* Guanqun Chao,3 Shuo Zhang4 1Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China; 2The First Affiliated Hospital of Zhejiang Chinese Medical ...
Feng S, Zhang C, Chen S, He R, Chao G, Zhang S   +5 more
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