Helminthic therapy: improving mucosal barrier function [PDF]
Trends in Parasitology, 2012 The epidemiology of autoimmune diseases and helminth infections led to suggestions that helminths could improve inflammatory conditions, which was then tested using animal models. This has translated to clinical investigations aimed at the safe and controlled reintroduction of helminthic exposure to patients suffering from autoimmune diseases (so ...
Martin J, Wolff +2 more
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Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. [PDF]
, 2019 There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking.
Aceves, Seema S +12 more
core +3 more sources
Intestinal macromolecular transport supporting adaptive immunity [PDF]
, 2019 The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core +2 more sources
Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier
Journal of Immunology Research, 2021 The intestinal mucosal immune barrier protects the host from the invasion of foreign pathogenic microorganisms. Immune cells and cytokines in the intestinal mucosa maintain local and systemic homeostasis by participating in natural and adaptive immunity.
Shanshan Chen +4 more
doaj +1 more source
TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. [PDF]
, 2013 Our gastrointestinal tract is a portal of entry for a number of bacteria and viruses. Thus, this tissue must develop ways to induce antigen-specific T cell and antibody responses quickly.
DePaolo, R William +5 more
core +1 more source
The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]
, 2015 Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B. +7 more
core +2 more sources
Gastrointestinal mucosal barrier function and diseases [PDF]
Journal of Gastroenterology, 2016 The gastrointestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment. Tight junctions (TJs) are the most important component for construction of a constitutive barrier of epithelial cells, and they regulate the permeability of the barrier by tightly sealing the cell-cell junctions.
Tadayuki, Oshima, Hiroto, Miwa
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Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets [PDF]
, 2017 Background: In this study the physiological implications of artificial rearing were investigated. Low (LBW) and normal birth weight (NBW) piglets were compared as they might react differently to stressors caused by artificial rearing.
Casteleyn, Christophe +9 more
core +1 more source
Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation [PDF]
, 2018 Current research into original therapies to treat intestinal inflammation is focusing on no-drug therapies. KLD is a mixture of krill oil (KO), probiotic Lactobacillus reuteri (LR), and vitamin D (VitD3).
Cesi, V. +9 more
core +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source