Results 21 to 30 of about 127,813 (257)
Quantitative dose-response analysis untangles host bottlenecks to enteric infection
Nature Communications, 2023 Here, using Citrobacter rodentium colonization of mice as a model, the authors characterize the impact of pathogen dose on the number of bacteria that initiate infection in the mouse gut, providing a framework for quantifying the host bottlenecks that ...
Ian W. Campbell +3 more
doaj +1 more source
The mucosal barrier at a glance [PDF]
Journal of Cell Science, 2017 ABSTRACT Mucosal barriers separate self from non-self and are essential for life. These barriers, which are the first line of defense against external pathogens, are formed by epithelial cells and the substances they secrete. Rather than an absolute barrier, epithelia at mucosal surfaces must allow selective paracellular flux that ...
Marion M. France, Jerrold R. Turner
openaire +2 more sources
Protective effect of citrulline on the intestinal
Pakistan Journal of Pharmaceutical Sciences, 2023 Excessive inflammation caused by sepsis can disrupt gut mucosal barrier and aggravate sepsis. The purpose of the study was to confirm whether citrulline can protect the intestinal mucosal barrier during sepsis.
Rui Xu, Lifang Qiu
doaj +1 more source
Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the
Li Zuo, Wei-Ting Kuo, Jerrold R. Turner
doaj +1 more source
Journal of Inflammation, 2022 Background Pyroptosis was implicated in acute lung injury (ALI). Disulfiram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD).
Jiping Zhao +6 more
doaj +1 more source
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2020 Aim of review. Description of intestinal mucosal barrier permeability disruption causes as morbid factors in gastrointestinal tract (GIT) functional disorders.General provisions.
A. L. Kovaleva +2 more
doaj +1 more source
Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis
iScience, 2023 Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang +8 more
doaj +1 more source
Perspectives on Mucosal Vaccines: Is Mucosal Tolerance a Barrier? [PDF]
The Journal of Immunology, 2007 Abstract Mucosal administration of Ags induces specific Abs in external secretions and systemic unresponsiveness termed oral or mucosal tolerance. The dominant response depends on the species studied, the nature, dose, frequency, route of Ag application, and the use of adjuvants.
Jiri, Mestecky +2 more
openaire +2 more sources
Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes
Frontiers in Immunology, 2021 Mucosal surfaces, as a first barrier with the environment are especially susceptible to damage from both pathogens and physical trauma. Thus, these sites require tightly regulated repair programs to maintain barrier function in the face of such insults ...
Joshua R. Cox +4 more
doaj +1 more source
Biliary Mucosal Barrier and Microbiome [PDF]
Visceral Medicine, 2015 <b><i>Background:</i></b> The biliary system is in continuous contact with the complex microbiota of the intestine. Microbial products have recently been proposed as potential triggers for biliary diseases. <b><i>Methods:</i></b> The aim of this review is to provide a summary of the current knowledge ...
Julien Verdier +2 more
openaire +2 more sources