Results 11 to 20 of about 134,087 (293)
Mucins in the mucosal barrier to infection [PDF]
Mucosal Immunology, 2008 The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment. All of these tissues are covered with resident microbial flora, which vary considerably in composition and complexity.
Linden, S. K. +4 more
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The Journal of Poultry Science, 2022 The mucosa of the intestine and oviduct of hens are susceptible to pathogens. Pathogenic infections in the mucosal tissues of laying hens lead to worsened health of the host animal, decreased egg production, and bacterial contamination of eggs ...
Takahiro Nii
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Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis
iScience, 2023 Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang +8 more
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Th17 Cytokines and the Gut Mucosal Barrier [PDF]
Journal of Clinical Immunology, 2010 Local immune responses serve to contain infections by pathogens to the gut while preventing pathogen dissemination to systemic sites. Several subsets of T cells in the gut (T-helper 17 cells, gammadelta T cells, natural killer (NK), and NK-T cells) contribute to the mucosal response to pathogens by secreting a subset of cytokines including interleukin (
Blaschitz, Christoph +1 more
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Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis [PDF]
The Turkish Journal of GastroenterologyBackground/Aims: Ulcerative colitis (UC), an idiopathic and chronic inflammatory disease, primarily targets the mucosal lining of the colon. This research endeavors to reveal the mechanism of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2 ...
Ruifan Li, Bin Gu, Anli Lv
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Tight junction channel regulation by interclaudin interference
Nature Communications, 2022 Tight junctions are formed by claudin proteins that can be classified as pore- or barrier-forming. Here, Shashikanth et al. report a third function, termed interclaudin interference, in which one claudin inhibits pore function of another claudin by ...
Nitesh Shashikanth +7 more
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Quantitative dose-response analysis untangles host bottlenecks to enteric infection
Nature Communications, 2023 Here, using Citrobacter rodentium colonization of mice as a model, the authors characterize the impact of pathogen dose on the number of bacteria that initiate infection in the mouse gut, providing a framework for quantifying the host bottlenecks that ...
Ian W. Campbell +3 more
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The mucosal barrier at a glance [PDF]
Journal of Cell Science, 2017 ABSTRACT Mucosal barriers separate self from non-self and are essential for life. These barriers, which are the first line of defense against external pathogens, are formed by epithelial cells and the substances they secrete. Rather than an absolute barrier, epithelia at mucosal surfaces must allow selective paracellular flux that ...
Marion M. France, Jerrold R. Turner
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Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the
Li Zuo, Wei-Ting Kuo, Jerrold R. Turner
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Journal of Inflammation, 2022 Background Pyroptosis was implicated in acute lung injury (ALI). Disulfiram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD).
Jiping Zhao +6 more
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