Results 31 to 40 of about 134,087 (293)

Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System

Advanced Science, 2022
The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are associated with superficial mucosal damage and intermittent wounding that leads to epithelial barrier defects and increased permeability. The standard therapeutic
Niranjan G. Kotla, Isma Liza Mohd Isa, Swetha Rasala, Secil Demir, Rajbir Singh, Becca V. Baby, Samantha K. Swamy, Peter Dockery, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit   +10 more
doaj   +1 more source

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

mBio, 2019
Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus ...
Carol L. Vinton, Samuel J. Magaziner, Kimberly A. Dowd, Shelly J. Robertson, Emerito Amaro-Carambot, Erik P. Karmele, Alexandra M. Ortiz, Carly E. Starke, Joseph C. Mudd, Stephen S. Whitehead, Sonja M. Best, Theodore C. Pierson, Heather D. Hickman, Jason M. Brenchley   +13 more
doaj   +1 more source

Editorial: Allergen source-specific mucosal barrier disruptors [PDF]

Frontiers in Allergy
Rajna Minić, Lidija Burazer, Andrijana Nešić, Sabine Flicker   +3 more
doaj   +2 more sources

Contribution of Lactobacilli on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of Lactobacillus casei

Life, 2022
The intestine barrier, the front line of normal body defense, relies on its structural integrity, microbial composition and barrier immunity. The intestinal mucosal surface is continuously exposed to a complex and dynamic community of microorganisms ...
Da Qin, Yixuan Ma, Yanhong Wang, Xilin Hou, Liyun Yu   +4 more
doaj   +1 more source

Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection [PDF]

, 2012
HIV/SIV disease progression is associated with multifocal damage to the GI tract epithelial barrier that correlates with microbial translocation and persistent pathological immune activation but the underlying mechanisms remain unclear.
Lifson, Jeffrey D., Tabb, B, Estes, Jacob D., Ortiz, A M, Haddad, Elias K., Barber, J S, Paiardini, M, Cervasi, Barbara, Tabb, Brian, Klatt, Nichole R., Barber, John S., Yokomizo, Lauren K., Pan, Li, Alter, Galit, Cervasi, B, Paiardini, Mirko, Vinton, Carol L., Harris, Levelle D., Harris, L D, Canary, L A, Alter, G, Belkaid, Yasmine, Sun, Xiaoyong, Yokomizo, L K, Vinton, C L, Hirsch, V M, Klatt, N R, Dang, Q, Ortiz, Alexandra M., Haddad, E K, Silvestri, Guido, Belkaid, Y, Silvestri, G, Brenchley, Jason M., Milner, J D, Pan, L, Canary, Lauren A., Milner, Joshua D., Hirsch, Vanessa M., Brenchley, J M, Dang, Que, Estes, J D, Sun, X, Lifson, J D   +43 more
core   +1 more source

Natural mucosal barriers and COVID-19 in children [PDF]

JCI Insight, 2021
Abstract COVID-19 is more benign in children compared to adults for unknown reasons. This contrasts with other respiratory viruses where disease manifestations are often more severe in children. We hypothesized that a more robust early innate immune response to SARS-CoV-2 may protect against severe disease and compared clinical outcomes,
Carl A. Pierce, Sharlene Sy, Benjamin Galen, Doctor Y. Goldstein, Erika Orner, Marla J. Keller, Kevan C. Herold, Betsy C. Herold   +7 more
openaire   +5 more sources

Mucus and Mucins: The Underappreciated Host Defence System

Frontiers in Cellular and Infection Microbiology, 2022
The mucosal surfaces that form the boundary between the external environment and the underlying tissue are protected by a mucus barrier. Mucin glycoproteins, both secreted and cell surface mucins, are the major components of the barrier. They can exclude
Yong Hua Sheng, Sumaira Z. Hasnain, Sumaira Z. Hasnain   +2 more
doaj   +1 more source

Intestinal barrier function and absorption in pigs after waeaning: a review

, 2011
Under commercial conditions, weaning of piglets is associated with social, environmental and dietary stress. Consequently, small-intestinal barrier and absorptive functions deteriorate within a short time after weaning.
Wijtten, P.J.A., Verstegen, M.W.A., Meulen, J., van der   +2 more
core   +1 more source

Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis [PDF]

, 2017
Background & Aims: Despite advances in therapeutic options, more than half of all patients with ulcerative colitis (UC) do not achieve long-term remission, many require colectomy, and the disease still has a marked negative impact on quality of life ...
Dziki, Jenna, Badylak, Stephen F., Smoulder, Adam, Turner, Neill J., Castleton, Arthur A, Sobieski, Eric, Keane, Timothy J., White, Lisa J.   +7 more
core   +1 more source

A major population of mucosal memory CD4(+) T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality. [Elektronisk resurs] [PDF]

, 2015
Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity.
Erjefält, Jonas,, Roepstorff, K, Grip, Olof,, Sandén, Caroline,, Hultman Patschan, Oliver,, Agace, William,, Holmkvist, Petra,, Schmidtchen, Artur,, Uronen-Hansson, Heli,, Gudjonsson, Sigurdur,, Håkansson, K, Lund University., Hornum, L, Marsal, Jan,   +13 more
core   +2 more sources