Results 61 to 70 of about 55,899 (275)

Rapid recovery of postnivolumab vemurafenib-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome after tocilizumab and infliximab administration [PDF]

, 2020
Background Immune checkpoint inhibitors such as nivolumab and targeted BRAF inhibitors have dramatically altered the treatment outcomes of metastatic melanoma over the past few years. Skin toxicity is the most common adverse event (AE) related to the
Maestro, Alessandra, Marcuzzi, Annalisa, Maximova, Natalia, Zanon, Davide   +3 more
core   +1 more source

Mucosal Melanoma: An Update

Actas Dermo-Sifiliográficas (English Edition), 2015
Mucosal melanoma is a rare melanoma subtype that differs from the cutaneous form of the tumor in its biology, clinical manifestations, and management. Diagnosis is usually late due to a lack of early or specific signs and the location of lesions in areas that are difficult to access on physical examination.
Ballester Sánchez R, de Unamuno Bustos B, Navarro Mira M, Botella Estrada R   +3 more
openaire   +3 more sources

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Intracranial haemorrhage in a dobermann puppy with von Willebrand's disease [PDF]

, 1995
Neurological examination of a lethargic, ataxic 12-week-old dobermann revealed decreased conscious proprioception in all its limbs. Haematological examination revealed a low platelet count.
Dunn, J.K., Dunn, K.J., Herrtage, M.E., Nicholls, P.K.   +3 more
core   +2 more sources

Oral mucosal melanoma [PDF]

Translational Research in Oral Oncology, 2017
Background: Oral mucosal melanoma (OMM) is relatively rare, runs an aggressive course, affects most frequently the hard palate and the maxillary gingiva, and may be multifocal. The aetiological factors and the chain of molecular events that give rise to OMM and to its growth and metastasis are largely unknown.
RAG Khammissa, M Altini, S Meer, J Lemmer, L Feller   +4 more
openaire   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Multidisciplinary approach and treatment of acral and mucosal melanoma

Frontiers in Oncology
Acral and mucosal melanoma are uncommon variants of melanoma. Acral melanoma has an age-adjusted incidence of approximately 1.8 cases per million individuals per year, accounting for about 2% to 3% of all melanoma cases.
Ana Fortuna, Teresa Amaral, Teresa Amaral   +2 more
doaj   +1 more source

Melanoma of the sinonasal mucosa: A report on the two cases and a review of the literature [PDF]

Vojnosanitetski Pregled, 2015
Introduction. Primary mucosal melanoma of the sinonasal tract is a rare neoplasm, accounting for less than 1% of all melanomas. It has an aggressive and unpredictable biologic behavior characterized by frequent incidence of local recurrence ...
Aleksić Aleksandra, Gajanin Radoslav, Đurđević Dejan, Novaković Zorica, Vranješ Dalibor, Spremo Slobodan, Travar Dmitar, Guzina-Golac Nataša, Tomić-Spirić Vesna   +8 more
doaj   +1 more source

Striking enhancement at the site of radiation for nivolumab-induced Stevens-Johnson syndrome [PDF]

, 2018
Stevens-Johnson syndrome is a rare adverse cutaneous drug reaction characterized by epidermal detachment of
Al-Omari, Ahmed, Rancour, Elizabeth A., Shah, Kishan M.   +2 more
core  

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]

, 2015
The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco, COVIELLO, Tommasina, DI MEO, Chiara, MATRICARDI, PIETRO, MONTANARI, ELITA   +4 more
core   +1 more source