Results 71 to 80 of about 55,899 (275)

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. [PDF]

, 2017
INTRODUCTION: Colorectal cancer remains the second leading cause of cancer death in the United States, and new strategies to prevent, detect, and treat the disease are needed.
Aka, Allison A., Pattison, Amanda M., Rappaport, Jeff A., Sato, Takami, Snook, Adam E., Waldman, Scott A.   +5 more
core   +2 more sources

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?

Dermatology Practical & Conceptual, 2016
Background: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%.
Tova Rogers, Melissa Pulitzer, Maria L. Marino, Ashfaq A. Marghoob, Oliver Zivanovic, Michael A. Marchetti   +5 more
doaj   +1 more source

Surgical Management of Vulvar Melanoma: A Case Series

Case Reports in Oncology, 2021
Vulvar malignant melanoma is the second most common subtype of vulvar cancer, accounting for 5–10% of all vulvar cancers. The prognosis is still very poor, although some advances have been achieved in the last years.
Manuel Sánchez-Prieto, Francesc Fargas, Francesc Tresserra, María González-Cao, Sonia Baulies, Rafael Fábregas   +5 more
doaj   +1 more source

Comparative study between two different staging systems (AJCC TNM VS BALLANTYNE’S) for mucosal melanomas of the Head & Neck [PDF]

, 2016
Background: Mucosal melanoma (MM) of head and neck (H&N) is a rare entity with a quite poor prognosis. Ballantyne’s staging system has been commonly used since 1970.
Aguilar-Romero, Madeleine, Luna Ortiz, Kuauhyama, Mosqueda Taylor, Adalberto, Peteuil, Nathalie, Vidrio-Morgado, Horacio, Villavicencio Valencia, Verónica, Zepeda-Castilla, Ernesto   +6 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Clinical Review of Mucosal Melanoma: The 11-Year Experience of a Referral Center

Dermatology Practical & Conceptual, 2023
Introduction: Mucosal melanoma  is a rare neoplasm. Late diagnosis is caused by occult anatomic sites and scarcity of symptoms. Novel biological therapies have now become available. Demographic, therapeutical and survival records on mucosal melanoma are
Marco Spadafora, Giacomo Santandrea, Michela Lai, Stefania Borsari, Shaniko Kaleci, Maria Banzi, Vincenzo Dario Mandato, Giovanni Pellacani, Simonetta Piana, Caterina Longo   +9 more
doaj   +1 more source

The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions [PDF]

, 2011
C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit
Atzori L, Bianco P, Cabras S, Castellanos ME, Difelice E, Faa G, Ferreli C, Mulas P, Nemolato S, Pilloni L   +9 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source