Combatting mucosal melanoma: recent advances and future perspectives
Melanoma Management, 2018 Mucosal melanomas are a rare subtype of melanoma and are associated with a particularly poor prognosis. Due to the rarity of the diagnosis, and the pace with which the management of cutaneous melanoma has evolved over recent years, there is little good ...
Helen Tyrrell, Miranda Payne
doaj +1 more source
High concordance between trained nurses and gastroenterologists in evaluating recordings of small bowel video capsule endoscopy (VCE) [PDF]
, 2018 Background & Aims: The video capsule endoscopy (VCE) is an accurate and validated tool to investigate the entire small bowel mucosa, but VCE recordings interpretation by the gastroenterologist is time-consuming.
Annibale, B +6 more
core +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
The Scientific World Journal, 2017 Oral mucosal melanoma is an uncommon, usually heavily melanin-pigmented, but occasionally amelanotic aggressive tumour with a poor prognosis. Despite radical surgery, radiotherapy, or chemotherapy, local recurrence and distant metastasis are frequent ...
Liviu Feller +2 more
doaj +1 more source
Primary subglottic malignant melanoma: a case report from Jordan
Electronic Physician, 2019 Primary mucosal melanoma is an under diagnosed and rare tumor. Subglottic malignant melanoma is the least common of mucosal melanoma. This paper reports a case of a 60-year-old man who presented to the ENT clinic at King Hussein Medical Center in 2015 ...
Qais Aljfout +5 more
doaj +1 more source
Metastases risk in thin cutaneous melanoma: Prognostic value of clinical-pathologic characteristics and mutation profile [PDF]
, 2018 Background: A high percentage of patients with thin melanoma (TM), defined as lesions with Breslow thickness ≤1 mm, presents excellent long-term survival, however, some patients develop metastases.
Calvieri, Stefano +12 more
core +1 more source
Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment
Advanced Science, EarlyView.This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang +7 more
wiley +1 more source
Pharyngeal and Cervical Cancer Incidences Significantly Correlate with Personal UV Doses Among Whites in the United States [PDF]
, 2014 Because we found UV-exposed oral tissue cells have reduced DNA repair and apoptotic cell death compared with skin tissue cells, we asked if a correlation existed between personal UV dose and the incidences of oral and pharyngeal cancer in the United ...
Godar, Dianne E. +2 more
core +1 more source
An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors [PDF]
, 2019 © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium ...
Au, L +17 more
core +3 more sources
Immunotherapy for mucosal melanoma
Annals of Translational Medicine, 2019 Mucosal melanoma is a rare subtype, representing 1% of all melanoma diagnoses (1). As compared to cutaneous melanoma, patients with mucosal melanoma often present with more advanced disease and prognosis is significantly worse (2).
Sarah, Yentz, Christopher D, Lao
openaire +2 more sources